ST6GALNAC2

ST6GALNAC2
Identifiers
Aliases	ST6GALNAC2 , SAITL1, SIAT7, SIAT7B, SIATL1, ST6GalNAII, STHM, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
External IDs	OMIM: 610137 MGI: 107553 HomoloGene: 4714 GeneCards: ST6GALNAC2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,586,956 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,585,694 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; right uterine tube; ; sural nerve; ; skin of abdomen; ; blood; ; right lobe of thyroid gland; ; right lung; ; gastrocnemius muscle; ; vagina; ; left lobe of thyroid gland;
	Top expressed in
	seminiferous tubule; ; superior surface of tongue; ; gallbladder; ; corneal stroma; ; submandibular gland; ; crypt of lieberkuhn of small intestine; ; kidney; ; conjunctival fornix; ; parotid gland; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity ; transferase activity ; sialyltransferase activity ; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ;
Cellular component	integral component of membrane ; Golgi apparatus ; membrane ; Golgi membrane ;
Biological process	sialylation ; oligosaccharide metabolic process ; O-glycan processing ; protein N-linked glycosylation via asparagine ; protein glycosylation ; protein O-linked glycosylation ; protein sialylation ;
	Sources:Amigo / QuickGO
Orthologs
	10610
	20446
	ENSG00000070731
	ENSMUSG00000057286
	Q9UJ37
	P70277
	NM_006456
	NM_009180
	NP_006447
	NP_033206
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 29, 2023

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 is an enzyme that in humans is encoded by the ST6GALNAC2 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070731 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057286 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (May 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. doi:10.1007/BF03402002. PMC 2039932 . PMID 11984005.
↑ "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".

Li GS, Zhu L, Zhang H, et al. (2007). "Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy". Hum. Mutat. 28 (10): 950–7. doi: 10.1002/humu.20543 . PMID 17480010. S2CID 7286057.
Raska M, Moldoveanu Z, Suzuki H, et al. (2007). "Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells". J. Mol. Biol. 369 (1): 69–78. doi:10.1016/j.jmb.2007.03.002. PMC 1995659 . PMID 17418236.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Samyn-Petit B, Krzewinski-Recchi MA, Steelant WF, et al. (2000). "Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells". Biochim. Biophys. Acta. 1474 (2): 201–11. doi:10.1016/s0304-4165(00)00020-9. PMID 10742600.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000070731 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057286 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11984005-5] Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (May 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. doi:10.1007/BF03402002. PMC 2039932 . PMID 11984005.

[entrez-6] "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".

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ST6GALNAC2

Related Research Articles

References

Further reading