Sibte Hasan Zaidi

Last updated

Sibte Hasan Zaidi was an Indian pathologist and toxicologist born in April 1918. He underwent training in pathology at the Hammersmith Hospital in London, United Kingdom and later returned to India to continue with experimental toxicology research. During his later years, he served on national and international committees, such as the World Health Organization where he advised on the harmful biological effects of industrial toxins.

Contents

Sibte Hasan died on April 5, 2008 at the age of 90 years.

Early life and career

Sibte Hasan Zaidi was born in Barabanki, India. He grew up in the village town of Jarwal with his maternal uncle, due to the early death of his mother, Zakia Begum. Thereafter, he studied at Barabanki High School while living with his father, Syed Hasan Zaidi, a barrister. Upon the death of his father in 1931, Sibte Zaidi moved in with his uncle, Sardar Husain. After graduating from Christian College and Lucknow University, Zaidi entered King George’s Medical College (KGMC, now King George's Medical University) in 1940. He graduated with a medical degree in 1945. In 1948, he married Qamar Ara Shanshah Husain, granddaughter Rajah of Bhatwamau, a clinical psychologist. After Zaidi's clinical training and a brief academic appointment in Pathology at KGMC, he left for Lonson to work under the tutelage of Professor Earl J. King at what's now known as the Imperial College and the Hammersmith Hospital. During his tenure at the Hammersmith, Zaidi earned a PhD (1954) and a Diploma in Clinical Pathology (1952), both from the University of London.

Research

Around 1950, Zaidi's mentor Earl J. King developed an interest in the health of coal miners in the Sheffield area. Zaidi assisted by providing description of the pathology and pathophysiology of coal miner’s lung. Zaidi and coworkers "produced the nearest approach to massive fibrosis by injecting into sensitized animals dust plus tubercle bacilli." [1]

In 1955, Zaidi travelled back to India to be named Head the Division of Experimental Medicine and Deputy Director at the Central Drug Research Institute (CDRI) in Lucknow, where his research focused on mechanisms that underlie peptic ulcer, atherosclerosis, vasospasm, and eosinophilia. Through a complement of pharmacologic and animal studies, Zaidi and his colleagues demonstrated the requirement of a mucus barrier in the prevention of peptic ulcer disease. [2] For this, he received the Sir Shanti Swaroop Bhatnagar Award for the scientific excellence in 1963. [3] He also made contributions to understanding the process of atherosclerosis, where he not only examined the mechanisms of hypercoagulability and thrombosis, but also developed rodent models of atherosclerotic heart disease and experimental myocardial infarction. [4]

Between 1964 and 1965, Zaidi served as the third Director of the newly founded Indian Institute of Biochemistry and Experimental Medicine in Calcutta (renamed Indian Institute of Chemical Biology), [5] where he established the institute's research infrastructure. Additionally, he initiated dissections and clarifications of the effect of exposure of industrial toxins on pulmonary fibrosis.

Industrial Toxicology Research Center (ITRC)

This work provided the stimulus for the emergence of a new discipline of Industrial Toxicology in India, where toxic exposure had remained an unrecognised health hazard. Zaidi became the Founding Director of the first institute in South East Asia – Industrial Toxicology Research Center (ITRC) in Lucknow (now renamed as Indian Institute of Toxicology Research, IITR). [6] The support of then-President of India V. V. Giri, and later by President Fakhruddin Ali Ahmed, increased awareness on the importance of the Center. Zaidi was commented in a journal entitled "Clinical Toxicology" for his role in nurturing many areas of industrial toxicology. [7] During his tenure at ITRC, Zaidi grew the Center and continued to work on cellular mechanisms through which industrial toxins affect human health. [8] His research was funded continuously by the Public Health Service of the United States through their PL480 scheme.

Publications

Zaidi's monograph "Experimental Pneumoconiosis" was published by Johns Hopkins Press in 1969. [9] Over 140 publications resulted from this work.

His Editorial "Bhopal and After," [10] published in the American Journal of Industrial Medicine, and later quoted in several articles, [11] highlighted gaps in 1980s policy that could lead to spillage of chemicals of such magnitude.

Recognition

Zaidi was awarded the William P. Yant Award for lifetime achievements and contributions to industrial toxicology by the American Industrial Hygiene Association in 1977. [12] [13] [14] He also served on their Editorial Board from 1977 to 1993. The Venezuelan Society gave him the highest honour for his contributions to industrial medicine (1978). For his work in India, he was awarded the Sir Ardeshirlal Dalal Gold Medal for his contributions to occupational health (1975), and the Padam Shree (1977) by the Government of India. [15] Zaidi was inducted as the Founding Member of the Royal College of Pathologists, and thereafter was conferred a Fellowship. He was inducted as a Fellow of the National Academy of Medical Sciences of India (1976), the National Academy of Sciences, India (1972), and the Indian National Science Academy (1974). [16] These honors are listed in his official obituary published by the Indian Institute of Toxicology Research. [17] In recognition of his contributions to ITRC, the Professor SH Zaidi Memorial Oration endowed annual lectureship was established in 1998. [18] [19] The 12th oration was given by his son, Professor Mone Zaidi. [20]

Policy and Positions

In 1975, Zaidi hosted "The International Symposium on Industrial Toxicology" in Lucknow, [21] which showcased the then-cutting-edge science in the field of industrial medicine. He was thereafter inducted as President of the Asian Society of Environmental Industrial Toxicology (1975). He was also Professor at the Azad University in Kanpur, and Visiting Professor to the University of Düsseldorf on two occasions, where he participated in further studies on the action of toxic metals.

Zaidi served on the United Nations Development Program (UNDP), World Health Organization (WHO), [22] and the International Labor Organization (ILO). [23] His work on the World Health Organization's Expert Committees became the basis of two key technical reports. [24] [25] He was also Advisor to the Occupational Health Committee of the WHO, Member of the Scientific Advisory Committee of the UN International Registry on Potentially Toxic Chemicals in Geneva (1977-1979), Senior Consultant to the United Nations Environmental Program (1982), and WHO Consultant in Bangladesh [26] and Burma. [27] He established international courses on preventive toxicology under the United Nations in Switzerland, USSR, Czechoslovakia and Germany. To promote the cause of industrial medicine, he founded two further institutes for outreach research in Rangoon (1982-1984) and Sri Lanka (1979), under the aegis of the United Nations.

In India, he served as Honorary Advisor to the Ministry of Railways, a position that he retained between 1978 and 1989. He chaired the Environmental Research Committee of the Ministry of Environment of the Government of India between 1990 and 1993.

Later life

During the late 1990s and thereafter, Zaidi lived intermittently in India, the United Kingdom, and the United States with his son, Mone Zaidi, who is attending physician at Mount Sinai Hospital, Professor of Medicine and of Pharmacological Sciences, and Director of the Center of Translational Medicine and Pharmacology at Icahn School of Medicine at Mount Sinai in New York. Zaidi died at his home in Riverdale, New York, on 5 April 2008. [28] [29]

Related Research Articles

<span class="mw-page-title-main">Pneumoconiosis</span> Class of interstitial lung diseases

Pneumoconiosis is the general term for a class of interstitial lung disease where inhalation of dust has caused interstitial fibrosis. The three most common types are asbestosis, silicosis, and coal miner's lung. Pneumoconiosis often causes restrictive impairment, although diagnosable pneumoconiosis can occur without measurable impairment of lung function. Depending on extent and severity, it may cause death within months or years, or it may never produce symptoms. It is usually an occupational lung disease, typically from years of dust exposure during work in mining; textile milling; shipbuilding, ship repairing, and/or shipbreaking; sandblasting; industrial tasks; rock drilling ; or agriculture. It is one of the most common occupational diseases in the world.

<span class="mw-page-title-main">Black lung disease</span> Human disease caused by long-term exposure to coal dust

Black lung disease (BLD), also known as coal-mine dust lung disease, or simply black lung, is an occupational type of pneumoconiosis caused by long-term inhalation and deposition of coal dust in the lungs and the consequent lung tissue's reaction to its presence. It is common in coal miners and others who work with coal. It is similar to both silicosis from inhaling silica dust and asbestosis from inhaling asbestos dust. Inhaled coal dust progressively builds up in the lungs and leads to inflammation, fibrosis, and in worse cases, necrosis.

M. Krishnan Nair was an Indian oncologist. He was the founding director of the Regional Cancer Centre, Thiruvananthapuram, a director of the S.U.T. Institute of Oncology, and Trivandrum Cancer Center(TCC), part of SUT Royal Hospital in Thiruvananthapuram (Trivandrum) and a professor at the Amrita Institute of Medical Sciences & Research in Kochi. The Government of India awarded him the fourth highest civilian award of the Padma Shri in 2001 for his contributions in the cancer care field.

<span class="mw-page-title-main">Indian Council of Medical Research</span> Government organization

The Indian Council of Medical Research (ICMR), the apex body in India for the formulation, coordination and promotion of biomedical research, is one of the oldest and largest medical research bodies in the world.

<span class="mw-page-title-main">Indian Institute of Toxicology Research</span>

The Indian Institute of Toxicology Research is a laboratory run under the aegis of Council of Scientific and Industrial Research. It was established in 1965 by Sibte Hasan Zaidi and has its main campus in Lucknow with a satellite campus at Gheru. The research is centered in the Asia-Pacific region.

The Institute of Occupational Medicine (IOM) was founded in 1969 by the National Coal Board (NCB) as an independent charity in Edinburgh, UK and retains its charitable purpose and status today. The "Institute" has a subsidiary, IOM Consulting Limited, which became fully independent in 1990 and now celebrates its 25th year within the IOM Group as an independent consultancy and also the commercial part of the IOM organization. It specializes in asbestos surveys and services, occupational hygiene services, nanotechnology safety, laboratory analysis and expert witness consulting services. IOM is therefore one of the UK's major independent "not for profit" centres of science in the fields of environmental health, occupational hygiene and occupational safety.

Vasant Ramji Khanolkar, better known as V. R. Khanolkar, was an Indian pathologist. He made major contributions to the epidemiology and understanding of cancer, blood groups, and leprosy. He has been called the "Father of Pathology and Medical Research in India."

<span class="mw-page-title-main">Aluminium phosphide poisoning</span> Type of poisoning

Aluminium phosphide poisoning is poisoning that occurs as a result of excessive exposure to aluminium phosphide (AlP), which is readily available as a fumigant for stored cereal grains and sold under various brand names such as QuickPhos, Salphos and Celphos. Aluminium phosphide is highly toxic, especially when consumed from a freshly opened container. Acute aluminium phosphide poisoning (AAlPP) is a large though under-reported problem throughout the world, particularly in the Indian subcontinent.

<span class="mw-page-title-main">Anil Kumar Tyagi</span> Indian academic (born 1951)

Anil Kumar Tyagi is former Vice Chancellor of Guru Gobind Singh Indraprastha University Delhi. Prior to this he was co-ordinator of UGC- SAP Programme and head of Department of Biochemistry at South Campus of Delhi University and was Vice President of the Society of Biological Chemists, India from the year 2004 to 2006.

Bishnupada Mukerjee or Bishnupada Mukhopadhyaya was an Indian pharmacologist and orthopedic surgeon, known for his contributions in the fields of pharmacological research and standardization of drugs in India. The Government of India honoured him in 1962, with the award of Padma Shri, the fourth highest Indian civilian award for his services to the nation.

Madhav Gajanan Deo is an Indian oncologist, pathologist and educationist, known for his contributions to the field of Molecular medicine. He is the founder president of the Indian Association of Cancer Research and one of the founders of the Moving Academy of Medicine and Biomedicine. He is a recipient of the Om Prakash Bhasin Award. The Government of India awarded him the fourth highest civilian award of Padma Shri in 1990.

Toppur Seethapathy Sadasivan was an Indian plant pathologist, academic and the director of the Centre for Advanced Studies in Botany of the University of Madras. He was the founder of the School of Physiological Plant Pathology at Madras University and was a recipient of the Shanti Swarup Bhatnagar Prize, the highest Indian award in the science category. He was an elected fellow of the Indian Academy of Sciences, Indian National Science Academy and Indian Botanical Society and an elected member of the Academy of Sciences Leopoldina. The Government of India awarded him the third highest civilian honour of the Padma Bhushan, in 1974, for his contributions to science.

Raman Viswanathan (1899–1982) was an Indian chest physician, medical mycologist and pulmonologist, considered by many as the father of Chest Medicine in India. He was the founder director of Vallabhbhai Patel Chest Institute, a postgraduate medical institute based in Delhi. An elected fellow of the American College of Chest Physicians, Royal College of Physicians of London, Indian National Science Academy and the Academy of Medical Sciences, United Kingdom, he was a recipient of several honors including the Forlanini Medal by Italian Tuberculosis Association and the Eugeno Morelli Prize of the National Academy of Sciences, Italy. The Government of India awarded him the third highest civilian honour of the Padma Bhushan, in 1974, for his contributions to medicine.

Umesh Chandra Chaturvedi was an Indian virologist, immunologist, medical microbiologist, CSIR Emeritus Scientist and a former chairman of the Bharat Immunologicals and Biologicals Corporation. The founder head of the department of microbiology at King George's Medical University, he is known for his studies on Dengue virus infection. Chaturvedi is an elected fellow of all the three major Indian science academies viz. Indian Academy of Sciences, National Academy of Sciences, India and the Indian National Science Academy as well as the Royal College of Pathologists and National Academy of Medical Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 1981.

Shyam Swarup Agarwal was an Indian geneticist, immunologist and the director of Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI-MS), Lucknow. A former director of the Advanced Center for Treatment, Research and Education in Cancer (ACTREC) at the Tata Memorial Centre, he was the pioneer of medical genetics and clinical immunology education in India. Known for his researches in the fields of genetics and molecular biology, he was an Emeritus Professor of the National Academy of Medical Sciences, and an elected fellow of all the three major Indian science academies, namely, the Indian Academy of Sciences, National Academy of Sciences, India, and the Indian National Science Academy. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 1986.

<span class="mw-page-title-main">Narinder Kumar Mehra</span> Indian immunologist (born 1949)

Narinder Kumar Mehra is an Indian immunologist, head of the department of transplant immunology and immunogenetics of the SRL Limited, Gurgaon. He is a former dean of research and holds the ICMR Dr. C.G. Pandit National Chair at AIIMS. An elected fellow of the International Medical Sciences Academy, The World Academy of Sciences, Indian National Science Academy and National Academy of Sciences, India, Mehra is known for his research on histocompatibility and immunogenetics. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 1992. He received the Chevalier of the National Order of Merit from François Mitterrand in 2003.

Kochupurackal P. Mohanakumar is an Indian chemical biologist, neuroscientist and the director of Inter University Centre for Biomedical Research and Super Specialty Hospital, Kottayam. He is a former chief scientist at the Indian Institute of Chemical Biology and is known for his studies on Parkinson's disease and Huntington's disease. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences in 2000.

Dennis J. Paustenbach PhD, CIH, DABT, is an American scientist, businessman, researcher, and author. Dennis is currently President of Paustenbach and Associates, which is a consulting firm who uses risk assessment techniques to characterize occupational and environmental health hazards. He is the founder and former president of ChemRisk, a consulting firm specializing in the use of toxicology and risk assessment to characterize the hazards of chemicals in soil, air, water, food, sediments and consumer products. He was, for about 4 years, a Group Vice-President of Exponent.

<span class="mw-page-title-main">Nikolai Izmerov</span> Soviet-Russian public figure (1927–2016)

Nikolai Fedotovich Izmerov was a Soviet and Russian occupational hygienist and public figure, who made significant contributions to occupational hygiene.

References

  1. ↑ Faulds, JS (1957). "Haematite pneumoconiosis in Cumberland miners". Journal of Clinical Pathology. 10 (3): 192–193. doi:10.1136/jcp.10.3.187. PMC   1024048 . PMID   13463104.
  2. ↑ Zaidi, SH; et al. (1957). "Experimental peptic ulceration.I. The significance of mucous barrier". Indian Journal of Medical Research. 46 (1): 27–37. PMID   13501871.
  3. ↑ "Prof. S.H. Zaidi Former Director, Passes Away" (PDF). Toxicology Research Bulletin. 28, 1: 2. May 2008. Archived from the original (PDF) on 1 June 2015. Retrieved 23 June 2015.
  4. ↑ Nityanand, S; Zaidi, SH (1963). "Experimental pulmonary embolism and arteriosclerosis. Effect of vasospasm 67: 529-538". American Heart Journal. 67 (4): 529–537. doi:10.1016/0002-8703(64)90101-2. PMID   14138816.
  5. ↑ CSIR-Indian Institute of Chemical Biology, Annual Report 2013-2014. "Former Directors" (PDF).{{cite web}}: CS1 maint: numeric names: authors list (link)
  6. ↑ Indian Institute of Toxicology Research
  7. ↑ Clinical Toxicology, News Item (1977). "Dedication of the New Buildings of Industrial Toxicology Research Center by Shri Fakhruddin Ali Ahmed, President of India on July 27, 1976". Clinical Toxicology. 10 (3): 389–390. doi:10.3109/15563657708992440.
  8. ↑ Rahman, Q; Vishwanathan, PN; Zaidi, SH (1977). "Some new perspectives on the biological effects of asbestos". Environmental Research. 14 (3): 487–498. Bibcode:1977ER.....14..487R. doi:10.1016/0013-9351(77)90056-1. PMID   145364.
  9. ↑ Zaidi, Sibte (1969). Experimental Pneumoconiosis (First ed.). Baltimore: The Johns Hopkins Press. p. 326.
  10. ↑ Zaidi, SH (1986). "Bhopal and After". American Journal of Industrial Medicine. 9 (3): 215–216. doi:10.1002/ajim.4700090302. PMID   3963002.
  11. ↑ Fielder, MP; et al. (2002). Methodological Issues in. Springer-Science+Business Media, B.V. p. 185. ISBN   978-1-4613-5163-4.
  12. ↑ American Industrial Hygiene Association. "The Yant Award". Archived from the original on 18 August 2017.
  13. ↑ Zaidi, SH (1977). "Yant Memorial Lecture...1977. Some aspects of experimental infective pneumoconiosis". Am Ind Hyg Assoc J. 38 (6): 239–45. doi:10.1080/0002889778507611. PMID   406771.
  14. ↑ Zaidi, SH (1977). "Yant Memorial Lecture...1977. Some aspects of experimental infective pneumoconiosis". Journal of the American Industrial Hygiene Association. 38 (6): 239–245. doi:10.1080/0002889778507611. PMID   406771.
  15. ↑ India Government Archives. "Archives, India.Gov.In". Archived from the original on 1 June 2015.
  16. ↑ Indian National Science Academy. "Deceased Fellows". Archived from the original on 13 August 2016.
  17. ↑ Toxicology Research Bulletin, Indian Institute of Toxicology Research. "Dr. S.H. Zaidi, Former Director, Passes Away" (PDF). Archived from the original (PDF) on 1 June 2015.
  18. ↑ Sibte Zaidi Oration. "Indian institute of Toxicology Research". Archived from the original on 1 June 2015.
  19. ↑ The Times of India. "The Indian Institute of Toxicology Research (IITR) is celebrating its 46th foundation day tomorrow". The Times of India .
  20. ↑ Professor SH Zaidi Oration. "Previous Orators". Archived from the original on 2 June 2015.
  21. ↑ OCLC WorldCat. Environmental pollution and human health : proceedings of the (first) International Symposium on Industrial Toxicology, Lucknow, November 4-7, 1975. OCLC   636880625.
  22. ↑ World Health Organization, Regional Office for South East Asia. "Chemical Safety in South East Asia Region" (PDF). WHO. Archived from the original (PDF) on 28 November 2003.
  23. ↑ International Labor Office, Geneva (1980). Occupational exposure to airborne substances harmful to health (PDF). p. 28. ISBN   978-92-2-102442-2.
  24. ↑ WHO Technical Report., Report of a WHO Study Group (1975). Early detection of health impairment in occupational exposure to health hazards (571 ed.).
  25. ↑ WHO Technical Report Series, Report of a WHO Scientific Group (1975). Chemical and biochemical methodology for assessment of hazards of pesticides for man (560 ed.). p. 26.
  26. ↑ World health Organization, WHO Project BAN OCH 001. "Industrial Health in Bangladesh".{{cite web}}: Missing or empty |url= (help)CS1 maint: numeric names: authors list (link)
  27. ↑ WHO Assignment Report. "Occupational Toxicology, Burma". World health Organization. Archived from the original on 10 June 2011.
  28. ↑ Biospectrum, The business of Bioscience. "Dr Zaidi passes away". Archived from the original on 4 March 2016.{{cite web}}: |first1= has generic name (help)
  29. ↑ Toxicology Research Bullettin, Industrial Toxicology Research Center. "Prof. S.H. Zaidi, Former Director Passes Away".{{cite web}}: Missing or empty |url= (help)
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.