Susan Lea (scientist)

Last updated
Susan Lea

Born
Susan Mary Lea

1969 (age 5354) [1]
Education Oxford High School, England
Alma mater University of Oxford (BA, DPhil)
Awards EMBO Member (2015) [2]
Scientific career
Fields Structural biology [3]
Institutions National Cancer Institute
National Institutes of Health
University of Oxford
Thesis Structural studies on foot-and-mouth disease virus  (1993)
Doctoral advisors David Stuart [4]
Website www.path.ox.ac.uk/content/susan-lea OOjs UI icon edit-ltr-progressive.svg

Susan Mary Lea FRS FMedSci (born 1969) [1] is a British biologist who serves as chief of the center for structural biology at the National Cancer Institute. Her research investigates host-pathogen interactions and biomolecular pathways. [3] [5] She was elected a Fellow of the Royal Society in 2022.

Contents

Early life and education

Lea was educated at Oxford High School and New College, Oxford where she received a Bachelor of Arts degree in Physiological Sciences in 1990. [1] Lea was a graduate researcher in the laboratory of molecular biophysics at the University of Oxford, where she worked under the supervision of David Stuart. During her doctoral research she made use of X-ray crystallography to better understand foot-and-mouth disease. [4]

Research and career

After her DPhil, she was awarded a Dorothy Hodgkin fellowship and started her independent research group in the department of biochemistry. [6] Her research looked to understand the structure-property relationships of human enteroviruses and their receptors. [7] Lea moved to the Sir William Dunn School of Pathology at Oxford, [7] [8] [9] where she was appointed lecturer in 1999, with a tutorial fellowship at Brasenose College, Oxford, [10] and chair of microbiology in 2016, with a professorial fellowship at Wadham College, Oxford. [11] In 2021, Lea moved to the National Institutes of Health, and was appointed Chief of the Center for Structural Biology at the National Cancer Institute. [7] [12]

Lea makes use of structural information from cryogenic electron microscopy and x-ray crystallography to understand biomolecules and medical pathways. She is particularly interested in molecular complexes that can cross the cellular membrane. She studies the serum resident protein cascades that are involved in immune responses. Lea has studied the interactions that define bacterial meningitis and dysentery. She determined the molecular architecture of the flagellum.[ citation needed ]

Awards and honours

Selected publications

Her publications [3] include:

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References

  1. 1 2 3 Anon (2018). "Lea, Prof. Susan Mary" . Who's Who (online Oxford University Press  ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U290639.(Subscription or UK public library membership required.)
  2. "Susan Lea". people.embo.org.
  3. 1 2 3 Susan Lea publications indexed by Google Scholar OOjs UI icon edit-ltr-progressive.svg
  4. 1 2 Lea, Susan Mary (1993). Structural studies on foot-and-mouth disease virus. ox.ac.uk (DPhil thesis). University of Oxford. OCLC   557273038. EThOS   uk.bl.ethos.357516. Open Access logo PLoS transparent.svg
  5. Susan Lea publications from Europe PubMed Central
  6. "Prof. Susan Lea - AcademiaNet". academia-net.org. Retrieved 2022-05-13.
  7. 1 2 3 "Principal Investigators". irp.nih.gov. NIH Intramural Research Program. Retrieved 2022-05-13.
  8. 1 2 "Susan Lea and Jordan Raff elected Fellows of the Royal Society | Sir William Dunn School of Pathology". path.ox.ac.uk. Retrieved 2022-05-13.
  9. "Susan Lea | Sir William Dunn School of Pathology". path.ox.ac.uk. Retrieved 2022-05-13.
  10. "Senior Members" (PDF). The Brazen Nose. 2008. Retrieved 16 May 2022.
  11. "Wadham Professor of Mathematics elected as Fellow of the Royal Society". Accolades. Wadham College, Oxford. 11 May 2022. Retrieved 16 May 2022.
  12. "Susan Lea". weforum.org. World Economic Forum . Retrieved 2022-05-13.
  13. "Susan Lea elected EMBO member | Sir William Dunn School of Pathology". path.ox.ac.uk. Retrieved 2022-05-13.
  14. "Professor Susan Lea | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2022-05-13.
  15. "65 Fellows Elected into the American Academy of Microbiology". ASM.org. Retrieved 2022-05-13.
  16. "Susan Lea". royalsociety.org. Retrieved 2022-05-13.
  17. E Blanc; P Roversi; C Vonrhein; C Flensburg; S M Lea; G Bricogne (December 2004). "Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT". Acta Crystallographica Section D: Biological Crystallography. 60 (Pt 12 Pt 1): 2210–21. doi:10.1107/S0907444904016427. ISSN   0907-4449. PMID   15572774. Wikidata   Q27860590.
  18. D Logan; R Abu-Ghazaleh; W Blakemore; et al. (8 April 1993). "Structure of a major immunogenic site on foot-and-mouth disease virus". Nature . 362 (6420): 566–8. Bibcode:1993Natur.362..566L. doi:10.1038/362566A0. ISSN   1476-4687. PMID   8385272. Wikidata   Q27732027.
  19. Elizabeth E Fry; Susan M. Lea; Jackson T; et al. (1 February 1999). "The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex". The EMBO Journal . 18 (3): 543–554. doi:10.1093/EMBOJ/18.3.543. ISSN   0261-4189. PMC   1171147 . PMID   9927414. Wikidata   Q38328829.