Related Research Articles
Chromosome 17 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 17 spans more than 83 million base pairs and represents between 2.5 and 3% of the total DNA in cells.
Polycomb-group proteins are a family of protein complexes first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place. Polycomb-group proteins are well known for silencing Hox genes through modulation of chromatin structure during embryonic development in fruit flies. They derive their name from the fact that the first sign of a decrease in PcG function is often a homeotic transformation of posterior legs towards anterior legs, which have a characteristic comb-like set of bristles.
Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Methylation activity of EZH2 facilitates heterochromatin formation thereby silences gene function. Remodeling of chromosomal heterochromatin by EZH2 is also required during cell mitosis.
E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.
Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.
Polycomb protein EED is a protein that in humans is encoded by the EED gene.
E3 ubiquitin-protein ligase RING1 is an enzyme that in humans is encoded by the RING1 gene.
40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene.
Enhancer of polycomb homolog 1 is a protein that in humans is encoded by the EPC1 gene.
Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. ATP1B3 has also been designated as CD298.
40S ribosomal protein S23 is a protein that in humans is encoded by the RPS23 gene.
40S ribosomal protein S12 is a protein that in humans is encoded by the RPS12 gene.
40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.
Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.
Cytochrome c oxidase subunit 6C is an enzyme that in humans is encoded by the COX6C gene.
28S ribosomal protein S21, mitochondrial is a protein that in humans is encoded by the MRPS21 gene.
PRC2 is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1.
Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. It was initially identified due to its binding capability to the promoter of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2).
Chromosome 15 open reading frame 52 is a human protein encoded by the C15orf52 gene, its function is poorly understood.
Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits, and degrades the RNA of RNA:DNA hybrids.
References
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: SUZ12 polycomb repressive complex 2 subunit pseudogene 1" . Retrieved 2016-04-06.
