TOE1

TOE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FC6
Identifiers
Aliases	TOE1 , hCaf1z, target of EGR1, member 1 (nuclear), PCH7, target of EGR1, exonuclease, TOE-1
External IDs	OMIM: 613931 MGI: 1915526 HomoloGene: 11823 GeneCards: TOE1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	45,343,973 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	116,664,837 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; parotid gland; ; right lobe of thyroid gland; ; smooth muscle tissue; ; rectum; ; lymph node; ; left lobe of thyroid gland; ; spleen; ; endothelial cell; ; thymus;
	Top expressed in
	primitive streak; ; renal corpuscle; ; morula; ; blastocyst; ; spermatocyte; ; superior cervical ganglion; ; medullary collecting duct; ; seminal vesicula; ; ureter; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3'-5'-exoribonuclease activity ; protein binding ; metal ion binding ; nucleic acid binding ; poly(A)-specific ribonuclease activity ; snRNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	cytoplasm ; Cajal body ; nuclear speck ; nucleolus ; nucleoplasm ; nucleus ; nuclear body ;
Biological process	RNA phosphodiester bond hydrolysis, exonucleolytic ; snRNA 3'-end processing ; regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	114034
	68276
	ENSG00000132773
	ENSMUSG00000028688
	Q96GM8
	Q9D2E2
	NM_025077
	NM_026654
	NP_079353
	NP_080930
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Target of EGR1 protein 1 is a protein that in humans is encoded by the TOE1 gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132773 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028688 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi: 10.1074/jbc.M210502200 . PMID 12562764.
↑ "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585 . PMID 15146077.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132773 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028688 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12562764-5] De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi: 10.1074/jbc.M210502200 . PMID 12562764.

[entrez-6] "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

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TOE1

Related Research Articles

References

Further reading