Tayyaba Hasan

Last updated
Tayyaba Hasan
Alma mater University of Karachi
University of Islamabad
University of Arkansas
Known for Visudyne
Scientific career
Fields Dermatology
Photodynamic therapy
Institutions University of Pennsylvania
Harvard Medical School
Massachusetts General Hospital
Website hasanlab.mgh.harvard.edu/about-us/tayyaba-hasan

Tayyaba Hasan is a Professor of Dermatology at the Wellman Center for Photomedicine at Harvard Medical School. She is one of the inventors of Visudyne, a Food and Drug Administration approved treatment for age-related macular degeneration. She received the 2018 SPIE Britton Chance Biomedical Optics Award.

Contents

Early life and education

Hasan completed her bachelor's degree in chemistry at the University of Karachi in 1966. [1] She earned her master's degree in 1968, specialising in organic chemistry. [1] In 1970 Hasan gained a second master's degree from the University of Islamabad. [1] She won the National Merit Scholarship from the Punjab Education Foundation. She moved to the University of Arkansas for her postgraduate research, earning a PhD in organic chemistry in 1980. [1] [2] She was elected to Sigma Xi. [3]

Research

After completing her PhD, Hasan joined the University of Pennsylvania as a postdoctoral research associate. She joined Harvard Medical School in 1982. [4] Hasan worked with Alan Oseroff on antibody conjugate photosensitization of cells for receptor-based photolysis. [5] She showed it was possible to target sub-cellular structures by photosensitisation. [5] [6] Hasan uses photodynamic therapy to diagnose and treat disease. [7] She has trained dermatologists, ophthalmologists, urologists, gynaecologists and orthopaedic surgeons. [5]

She demonstrated that benzoporphryin derivatives could be used to eliminate of subretinal vessels. [5] She went on to discover visudyne with Ursula Schmidt. [5] Visudyne is one of over twenty patents held by Hasan. [5] She was appointed to professor of dermatology in 2009. [8] Her recent work considers ways to target glioma treatment and ovarian cancer. [5] In 2011 she was the founding director of the Office for Research Career Development at Massachusetts General Hospital. [9] She is targeting diseases such as leishmaniasis, mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus. [9] Hasan's lab focusses on the photophysical and biological mechanisms of photodynamic therapy. [10] She leads a National Cancer Institute funded project focussed on image-guided therapy for pancreatic and skin cancers. [11] [12] These include singlet oxygen formation, cytokine secretion. [10]

The Hasan Lab run several separate research projects: [13]

Hasan has served on the executive boards of several learned societies, including acting as President of the International Photodynamic Association, Vice President of Science for the Pan American PDT Association and President of the American Society for Photobiology (2010 - 2012). [18] She contributed to the 2014 book Photodynamic Therapy: From Theory to Application. [4] She serves on the advisory board of Polythea. [19]

Awards

Related Research Articles

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References

  1. 1 2 3 4 "Tayyaba Hasan on developments in photodynamic therapy". spie.org. Retrieved 2018-08-20.
  2. "Fayetteville Northwest Arkansas Times Archives, Apr 11, 1979, p. 11". NewspaperArchive.com. 1979-04-11. Retrieved 2018-08-20.
  3. "Sigma Xi member directory". Sigma Xi. Retrieved 2018-08-19.
  4. 1 2 Abdel-Kader, Mahmoud H. (2014-01-09). Photodynamic Therapy: From Theory to Application. Springer Science & Business Media. ISBN   9783642396298.
  5. 1 2 3 4 5 6 7 Pogue, Brian W.; Wagnières, Georges; Lilge, Lothar D. (September 2010). "Special Section Guest Editorial: Pioneers in Biomedical Optics: Special Section Honoring Professor Tayyaba Hasan". Journal of Biomedical Optics. 15 (5): 051601–051601–2. Bibcode:2010JBO....15e1601P. doi: 10.1117/1.3492580 . ISSN   1083-3668. PMID   21054075.
  6. Shea, C. R.; Chen, N.; Wimberly, J.; Hasan, T. (1989-07-15). "Rhodamine dyes as potential agents for photochemotherapy of cancer in human bladder carcinoma cells". Cancer Research. 49 (14): 3961–3965. ISSN   0008-5472. PMID   2736534.
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  8. "Tayyaba Hasan, PhD - DF/HCC". www.dfhcc.harvard.edu. Retrieved 2018-08-20.
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