U.S. Route 11 or U.S. Highway 11 (US 11) is a major north–south United States Numbered Highway extending 1,645 miles (2,647 km) across the eastern U.S. The southern terminus of the route is at US 90 in Bayou Sauvage National Wildlife Refuge in eastern New Orleans, Louisiana. The northern terminus is at the Rouses Point–Lacolle 223 Border Crossing in Rouses Point, New York. The route continues across the border into Canada as Route 223. US 11, created in 1926, maintains most of its original route. The route north of Knoxville, Tennessee, follows a route similar to Interstate 81 (I-81). While it is signed as a north–south route, it physically travels in a northeast–southwest direction.
State Route 168 is a state highway in Knox County, Tennessee, that is 18.1 miles long. Its western terminus is with US 129/SR 115, and its eastern terminus is with US 11/US 11E/US 11W/US 70/SR 1.
U.S. Route 11W (US 11W) is the western branch of US 11 from the twin cities of Bristol, Tennessee/Bristol, Virginia, where US 11 splits into US 11E and US 11W, to Knoxville, Tennessee, where the two highways rejoin. The highway serves the Appalachia region's Ridge-and-Valley section of East Tennessee, bounded by the Clinch Mountain ridge to the north and the Holston River to the south. US 11W from Bristol to Bean Station and Blaine to Knoxville are designated as part of the National Highway System.
U.S. Route 11E (US 11E) is a divided highway of US 11 in the U.S. states of Tennessee and Virginia. The United States Numbered Highway, which is complemented by US 11W to the north and west, runs 120.94 miles (194.63 km) from US 11, US 11W, and US 70 in Knoxville, Tennessee, north and east to US 11, US 11W, US 19, and US 421 in Bristol, Virginia. US 11E connects Knoxville and the twin cities of Bristol, Virginia, and Bristol, Tennessee, with the East Tennessee communities of Morristown, Greeneville, and Johnson City. The U.S. Highway runs concurrently with US 70 and US 25W east of Knoxville, US 321 from Greeneville and Johnson City, and both US 19W and US 19 between Johnson City and Bristol. US 11E also has an unsigned concurrency with State Route 34 (SR 34) for almost all of its course in Tennessee.
U.S. Route 25W (US 25W) is the western branch of US 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin.
U.S. Route 11 (US 11) is a north–south United States Numbered Highway in western Virginia. At 339 miles (546 km), it is the second longest numbered route and longest primarily north–south route in the state. It enters the state from Tennessee as the divided routes US 11E and US 11W at Bristol, roughly follows the West Virginia border through the Blue Ridge Mountains and Shenandoah Valley, and enters the Eastern Panhandle of West Virginia from Frederick County. Most of the route closely parallels I-81. From south to north, US 11 serves the cities and towns of Bristol, Abingdon, Wytheville, Pulaski, Radford, Christiansburg, Roanoke, Lexington, Staunton, Harrisonburg, Strasburg, and Winchester. As one of the original U.S. Highways, it was first designated through Virginia in 1926 and has largely followed the same route since. Prior to the construction of the Interstate Highway System, it was the primary long-distance route for traversing the western part of the state. Much of it roughly follows the Great Wagon Road, a colonial-era road that followed the Appalachian Mountains from Georgia to Pennsylvania.
U.S. Route 421 (US 421) is a part of the U.S. Highway System that runs from Fort Fisher, North Carolina to Michigan City, Indiana. In Virginia, the U.S. Highway runs 69.23 miles (111.41 km) from the Tennessee state line between the twin cities of Bristol, Tennessee and Bristol, Virginia north and west to the Kentucky state line near St. Charles. Between its endpoints, US 421 has lengthy concurrencies with US 23 and US 58 during its course through Bristol, Weber City, Gate City, Duffield, and Pennington Gap in Southwest Virginia.
U.S. Route 19 (US 19) is a part of the United States Numbered Highway System that runs from Memphis, Florida, to Erie, Pennsylvania. In Virginia, the highway runs 88.89 miles (143.05 km) between two pairs of twin cities: Bristol, Tennessee, and Bristol, Virginia, at the Virginia–Tennessee state line, and Bluefield, Virginia, and Bluefield, West Virginia, at the Virginia–West Virginia state line. Between its endpoints, US 19 has lengthy concurrencies with US 11, US 58 Alternate, and US 460 during its course connecting Abingdon, Lebanon, and Tazewell within Washington, Russell, and Tazewell counties in Southwest Virginia.
State Route 44 is a state highway in the U.S. state of Tennessee. It runs from US 11E/US 19W/SR 34 in Bluff City, just south of the split of US 19W and US 19E, northeast via Hickory Tree and Holston Valley to the Virginia state line, where it becomes Virginia State Route 75. The entire highway is located within Sullivan County.
State Route 66 is a state-maintained highway in eastern Tennessee, including a six-lane divided highway known as Winfield Dunn Parkway in Sevier County, a four-lane expressway in Hamblen and Jefferson counties and a two-lane rural collector through mountainous terrain continuing to the northeast terminus in Hancock County.
State Route 9 (SR 9) is a west-to-east state highway in the U.S. state of Tennessee that is 131.33 miles (211.36 km) long. It begins in Campbell County and ends in Cocke County. SR 9 is little-known by the general public by this designation as it is overlain by U.S. Route 25W and U.S. Route 25 east of Newport; the "9" designation is seen on mileposts. The entire route is located in East Tennessee. Despite running concurrent with a North-South US Route, Route 9 is signed as east-west.
State Route 62 is a 87.5-mile-long (140.8 km) west-to-east highway in the U.S. state of Tennessee. It is designated as a primary route except for the short segment between SR 169 and its eastern terminus, which is secondary.
State Route 131 is a south-to-north highway in the U.S. state of Tennessee that is 68.8 miles long. It is designated as a secondary route.
State Route 61 is a west-to-east highway in the U.S. state of Tennessee that is 81.67-mile-long (131.44 km). State Route 61 begins in Roane County, and it ends in Grainger County.
U.S. Route 11 (US 11) in the U.S. state of Tennessee travels from the Georgia state line in Chattanooga to Knoxville, where it then splits into US 11E and US 11W. These two highways then travel to the Virginia state line near Kingsport and Bristol. During its length, it shares concurrencies with State Route 2 (SR 2) and SR 38.
State Route 107 is a 78.77-mile (126.77 km) state highway in eastern Tennessee, United States. It begins at an intersection with Round Mountain Road south of Del Rio and ends at the North Carolina state line east of Unicoi, where it becomes NC 226.
U.S. Route 421 is a north–south United States highway that runs for 43.4 miles (69.8 km) in East Tennessee, connecting the cities of Mountain City and Bristol.
State Route 36 (SR 36) is a 28.6-mile-long (46.0 km) state highway, broken in two segments. In Unicoi County, it serves as the hidden concurrency of U.S. Route 19W; in Washington and Sullivan counties, it serves as a stand-alone secondary road connecting the cities of Johnson City and Kingsport.
State Route 32 is a state highway in East Tennessee. For most of its route, it is an unsigned companion route concurrent with U.S. Route 25E. The highway stretches 89 miles from the North Carolina state line to the Tennessee-Kentucky state line near the town of Cumberland Gap.
State Route 35 is a north–south state highway in East Tennessee. The 81.35 miles (130.92 km) long state highway traverses Blount, Sevier, a small portion of Jefferson, Cocke, and Greene Counties. Most of the route is a secret, or hidden designation, as it runs concurrently with U.S. Highways in the area.
NC 208 near South Greene 
US 321 / SR 107 / SR 350 at Greeneville 
US 11E at Greeneville
I-81 near Romeo 
US 11W at Rogersville 
SR 70 at Blackwater, Virginia 
