The Center for Vital Longevity

Last updated
Center for Vital Longevity
Established
2010 (2010)
(12 years ago)
Research type Age-Related Cognitive Decline, Neuroscience of Aging
Director Michael D. Rugg
Location Dallas, Texas, U.S.
Operating agency
University of Texas at Dallas
Website cvl.utdallas.edu

Center for Vital Longevity (CVL) is a research center of the University of Texas at Dallas. [1] CVL houses scientists studying the cognitive neuroscience of aging and ways to maintain cognitive health for life. [2] Researchers at the CVL also investigate how to slow cognitive aging and methods for the early detection of age-related neurodegenerative disorders, such as Alzheimer's disease. Other research includes studies investigating the cognitive neuroscience of memory, and other fundamental cognitive processes. [3]

Contents

History

Dr. Michael D. Rugg, Director of the CVL Micheal-Rugg-02.jpg
Dr. Michael D. Rugg, Director of the CVL

Founded in 2010 by Dr. Denise C. Park, [4] the current director of research, the Center was joined by current director Michael D. Rugg [5] in 2011. Both Park and Rugg are fellows of the American Association for the Advancement of Science (AAAS) and the Association for Psychological Science and hold distinguished chairs in the UT Dallas School of Behavioral and Brain Sciences. Seven full-time faculty belong to the Center, with each faculty member leading a research group comprising a mixture of postdoctoral fellows, graduate students and research assistants.

Center researchers are supported by several competitively reviewed research grants. These grants fund recently completed and ongoing research programs. Among these are the “Synapse Project,” led by Park, which tested the hypothesis that leading an engaged lifestyle facilitates brain health and may slow down the process of normal cognitive aging, as well as two large-scale studies examining brain structure and function across the course of a healthy lifespan. [6]

Center investigators maintain affiliations and research collaborations with local, national, and international universities including UT Southwestern Medical Center, UT Arlington, University of Illinois, University of Michigan, University of Pennsylvania, Duke National University of Singapore, and University College London. [7] Research articles by Center scientists have appeared in such peer-reviewed scientific journals as Proceedings of the National Academy of Sciences of the United States of America, Neuron (journal), Nature Neuroscience, Journal of Cognitive Neuroscience, Journal of Neuroscience, and Neuropsychologia. [8]

Research

Scientists at the Center for Vital Longevity are engaged in a variety of research studies aimed at understanding memory, cognitive aging, and Alzheimer’s Disease. Recent CVL studies use structural and functional neuroimaging technologies to understand changes that occur in the brain over a lifetime and how these changes affect specific cognitive abilities and behaviors The Center’s six laboratories include:

Aging Mind Lab [9]

Led by Denise Park, the lab studies the same participants over many years as part its Dallas Lifespan Brain Study (DLBS), a large-scale longitudinal research project designed to characterize neural and cognitive aging across the entire adult lifespan from age 20 to 90. The DLBS focuses on predicting the cognitive future of healthy adults by imaging amyloid plaques associated with Alzheimer’s Disease that many healthy people carry. Supported by an NIH MERIT award, as well as funding from Avid Radiopharmaceuticals, the lab images amyloid deposits using florbetapir in healthy adults. Findings were featured at the 2014 International Alzheimer’s Association Conference held in Copenhagen [10] A second major study, The Synapse Project, [11] has found that engaging in mentally demanding leisure activities like quilting, photography, or learning iPad apps, supports memory function in older adults. Both the DLBS and The Synapse Project are funded by the National Institute on Aging and involve collaboration with other CVL faculty. Park participates extensively in NIH review panels and has chaired for nine years the International Scientific Review Committee (Beirat) for the Max Planck Institute for Human Development in Berlin, Germany. [12] ) Another area of recent inquiry for the lab is a research program that examines cultural differences in cognitive and neural aging, specifically, how immersing in a cultural context could influence both structural and functional circuits of the brain.

Functional Neuroimaging Memory Lab [13] Led by Center Director Michael D. Rugg, this lab focuses on understanding the neural circuits that support the encoding and retrieval of memories, and how these circuits vary in their function across the adult lifespan. With funding from the National Institute of Mental Health and the National Institute on Aging, Rugg and his laboratory employ the methods of functional and structural MRI, electroencephalography and transcranial magnetic stimulation. The lab’s research addresses several of questions, including whether brain regions involved in successful retrieval differ in the time-courses of retrieval-related neural activity they manifest, and how neural activity linked to successful memory encoding varies with age.

Rugg is editor-in-chief of the international journal Neuropsychologia, [14] and was appointed in 2014 as a standing member of the Neurobiology of Learning and Memory Study Section of the National Institutes of Health. He is the former chair of the Cognition and Perception Study Section

Cognitive Neuroimaging Lab [15] Led by Dr. Gagan Wig, the Cognitive Neuroimaging Laboratory uses a combination of structural and functional brain imaging measurements to understand the organization of large-scale human brain connectivity networks, and determine how these networks change over the adult lifespan.

The laboratory’s research program utilizes complex network science to further understand the brain basis of healthy and pathological aging. A number of inter-institutional research collaborations allow the researchers to focus on questions related to both aging and psychiatric disorders in large samples of participants (e.g., Alzheimer’s Disease and Major Depressive Disorder).

A 2014 paper [16] published by the group in the Proceedings of the National Academy of Sciences revealed novel observations related to how the brain operates on a network level, and of understanding the brain basis of individual differences in memory function among individuals aged 20 to 89. In addition to giving a number of invited lectures to both the general public and scientific audiences, Wig serves on the editorial board of the scientific journal NeuroImage. Dr. Wig joined the CVL in 2013 from Washington University in St. Louis, where he completed a post-doctoral fellowship working with the Human Connectome Project.

Lifespan Neuroscience and Cognition Lab [17] Led by Chandramallika Basak, the Lifespan Neuroscience and Cognition Laboratory focuses on the interplay between attention and memory, and the effects of cognitive training, including video games and memory exercises, in young and older adults. In particular, she and her team are currently testing a new model of working memory that emphasizes the role of attentional control and long-term memory. The lab is also determining specific conditions under which the processing capacity can be expanded (e.g., probe predictability, illusory conjunctions and inter-hemispheric connections, hours of practice), while exploring the biomarkers and neural correlates of complex skill learning and working memory. The goal is to determine the best strategies to improve cognition through working memory or game training. In 2014, her lab received a Darrell K. Royal Research Fund for Alzheimer’s Disease award, [18] a three year-grant totaling $165,000 to support research into mild cognitive impairment (MCI) and how acquiring skills with video games can be associated with improved cognitive performance. The funds extend her cognition work into new populations of older adults. Dr. Basak’s proposal was one of five research proposals recommended in Texas for the grant by an outside panel of peers led by Ronald C. Petersen, M.D., Ph.D., director of the Mayo Clinic’s Alzheimer’s Disease Research Center. [19]
Neuroimaging of Aging and Cognition Lab [20] Led by Dr. Kristen Kennedy, the lab investigates how the structure and the function of the normal aging brain intersect to affect how we age cognitively. The lab also investigates genetic factors that influence these relationships with the aim of determining who ages with minimal cognitive decline versus those who have a more pathological outcome. The laboratory studies use neuroimaging techniques such as functional and structural MRI to investigate properties of grey matter (e.g., cortical thickness measures) and white matter (e.g., white matter connectivity) structure and brain function as well as neuropsychological and cognitive performance tests. The laboratory’s research is funded through a National Institute on Aging grant, and supplemented by foundation grants and private gifts.
Human Aging Lab [21] Led by Dr. Karen Rodrigue, the Human Aging laboratory studies the role of vascular risk in neural and cognitive aging. She currently serves as the primary investigator for a National Institutes of Health Pathway to Independence grant awarded to top junior scientists in the United States. Her work also focuses on health factors such as hypertension and how high blood pressure can influence aging and the deposition of beta amyloid in the brain, a protein associated with the development of Alzheimer’s Disease. Supported by funding from UT Dallas, and the provision of the imaging agent florbetapir from Eli Lilly, Inc., her laboratory studies the relationship between brain iron accumulation and cognitive decline in older adult. Her lab is also investigating links to brain iron accumulation and the accumulation of beta amyloid. The Human Aging Laboratory uses a variety of methods to assess brain and cognitive aging, including structural and functional MRI and PET imaging. In 2014, Dr. Rodrigue was named a “Rising Star” by the American Psychological Society. [22]
Aging Well LabLed by Dr. Kendra Seaman, the Aging Well Lab is the latest addition to the Center for Vital Longevity. The lab's research is dedicated to using basic and translational scientific research studies to promote health and wellbeing across adulthood. The lab uses a variety of behavioral, modeling, and neuroimaging techniques to better understand how the mind and the brain changes as people get older.
The Center for Vital Longevity building The Center for Longevity building on Viceroy Drive, Dallas, Texas.jpg
The Center for Vital Longevity building

Advisory Council

The Center for Vital Longevity has an Advisory Council consisting of roughly 20 members, each serving three-year terms. The goal of the Advisory Council is to enhance the Center’s development and help promote its research on the aging mind. Council members are committed to the identification, cultivation, solicitation and stewardship of donors and potential donors, including corporate partners, foundations, individuals and others. [23]

Facilities

The Center’s facilities, in Dallas, Texas, include several research laboratories, including those dedicated to EEG and trans-cranial magnetic stimulation (TMS). Investigators conduct functional and structural neuroimaging studies at the Advanced Imaging Research Center (AIRC) [24] on the nearby campus of the University of Texas Southwestern Medical Center part of a collaborative enterprise between UT Dallas, UT Arlington and UT Southwestern.

Related Research Articles

Cognitive neuroscience Scientific field

Cognitive neuroscience is the scientific field that is concerned with the study of the biological processes and aspects that underlie cognition, with a specific focus on the neural connections in the brain which are involved in mental processes. It addresses the questions of how cognitive activities are affected or controlled by neural circuits in the brain. Cognitive neuroscience is a branch of both neuroscience and psychology, overlapping with disciplines such as behavioral neuroscience, cognitive psychology, physiological psychology and affective neuroscience. Cognitive neuroscience relies upon theories in cognitive science coupled with evidence from neurobiology, and computational modeling.

The following outline is provided as an overview of and topical guide to neuroscience:

The University of Texas Southwestern Medical Center is a public academic health science center in Dallas, Texas. With approximately 13,568 employees and 2,445 faculty and over 2.7 million outpatient visits per year, UT Southwestern is the largest medical school in the University of Texas System and state of Texas.

John Gabrieli is a neuroscientist at MIT, and an associate member of the McGovern Institute for Brain Research. He is a faculty member in the department of Brain and Cognitive Sciences and director of the Martinos Imaging Center, part of the McGovern Institute. Gabrieli is an expert on the brain mechanisms of human cognition, including memory, thought and emotion. His work includes neuroimaging studies on healthy adults and children as well as clinical patients with many different brain disorders, including schizophrenia, depression, Alzheimer's disease, autism and dyslexia.

Anna Christina Nobre Neuroscientist

Anna Christina Nobre, FBA, MAE, fNASc, known as Kia Nobre is a Brazilian and British cognitive neuroscientist working at the University of Oxford in the United Kingdom.

Basic science (psychology)

Some of the research that is conducted in the field of psychology is more "fundamental" than the research conducted in the applied psychological disciplines, and does not necessarily have a direct application. The subdisciplines within psychology that can be thought to reflect a basic-science orientation include biological psychology, cognitive psychology, neuropsychology, and so on. Research in these subdisciplines is characterized by methodological rigor. The concern of psychology as a basic science is in understanding the laws and processes that underlie behavior, cognition, and emotion. Psychology as a basic science provides a foundation for applied psychology. Applied psychology, by contrast, involves the application of psychological principles and theories yielded up by the basic psychological sciences; these applications are aimed at overcoming problems or promoting well-being in areas such as mental and physical health and education.

Michael Derek Rugg FRSE is a Distinguished Chair in Behavioral and Brain Sciences at University of Texas at Dallas. He is director of The Center for Vital Longevity in Dallas, Texas. His current research program involves the use of electrophysiological and functional magnetic resonance imaging (fMRI) methods to investigate the cognitive and neural bases of memory encoding and memory retrieval, as well as how and why memory function differs as a result of healthy aging or neurological disease.

Broadly defined, positive neuroscience is the study of what the brain does well. Instead of studying mental illness, positive neuroscientists focus on valued cognitive qualities that serve to enrich personal life and/or society. Topics in positive neuroscience overlap heavily with those of positive psychology, but use neuroimaging techniques to extend beyond the behavioral level and explain the neurobiology which underpins "positive" cognitive phenomena such as intelligence, creativity, optimism, and healthy aging.

Educational neuroscience is an emerging scientific field that brings together researchers in cognitive neuroscience, developmental cognitive neuroscience, educational psychology, educational technology, education theory and other related disciplines to explore the interactions between biological processes and education. Researchers in educational neuroscience investigate the neural mechanisms of reading, numerical cognition, attention and their attendant difficulties including dyslexia, dyscalculia and ADHD as they relate to education. Researchers in this area may link basic findings in cognitive neuroscience with educational technology to help in curriculum implementation for mathematics education and reading education. The aim of educational neuroscience is to generate basic and applied research that will provide a new transdisciplinary account of learning and teaching, which is capable of informing education. A major goal of educational neuroscience is to bridge the gap between the two fields through a direct dialogue between researchers and educators, avoiding the "middlemen of the brain-based learning industry". These middlemen have a vested commercial interest in the selling of "neuromyths" and their supposed remedies.

The late positive component or late positive complex (LPC) is a positive-going event-related brain potential (ERP) component that has been important in studies of explicit recognition memory. It is generally found to be largest over parietal scalp sites, beginning around 400–500 ms after the onset of a stimulus and lasting for a few hundred milliseconds. It is an important part of the ERP "old/new" effect, which may also include modulations of an earlier component similar to an N400. Similar positivities have sometimes been referred to as the P3b, P300, and P600. Here, we use the term "LPC" in reference to this late positive component.

Arthur Paul Shimamura was a professor of psychology and faculty member of the Helen Wills Neuroscience Institute at the University of California, Berkeley. His research focused on the neural basis of human memory and cognition. He received his BA in experimental psychology from the University of California, Santa Barbara in 1977 and his PhD in cognitive psychology from the University of Washington in 1982. He was a post-doctoral fellow in the laboratory of Larry Squire, where he studied amnesic patients. In 1989, Shimamura began his professorship at UC Berkeley. He has published over 100 scientific articles and chapters, was a founding member of the Cognitive Neuroscience Society, and has been science advisor for the San Francisco Exploratorium science museum.

Center for BrainHealth Research institute

The Center for BrainHealth, part of The University of Texas at Dallas' school of Behavioral and Brain Sciences, is a research institute focused exclusively on brain health that combines brain research with clinical interventions. Founded by Dr. Sandra Bond Chapman in 1999, the Center for BrainHealth houses 125 researchers, postdoctoral research fellows, doctoral students, master's students, and research clinicians who work on 60 privately and federally funded research projects. The Center provides academic training and houses specialists in, among many others, Alzheimer's disease, traumatic brain injury (TBI), healthy brain aging, multiple sclerosis, autism, attention deficit hyperactivity disorder (ADHD), stroke, and posttraumatic stress disorder (PTSD). To help raise awareness of and funding for research underway at the Center for BrainHealth, a number of proponent groups have formed. These include the Think Ahead Group (TAG) of young professionals and Friends of BrainHealth.

Sandra Bond Chapman

Sandra Bond Chapman is a cognitive neuroscientist, founder and chief director of the Center for BrainHealth, Dee Wyly Distinguished Professor in Brain Health, and a professor in the School of Behavioral and Brain Sciences at The University of Texas at Dallas.

Hans Joachim Markowitsch is a physiological psychologist and neuropsychologist whose work centers on brain correlates of memory and memory disorders, stress, emotion, empathy, theory of mind, violent and anti-social behavior and consciousness.

The Human Connectome Project (HCP) is a five-year project sponsored by sixteen components of the National Institutes of Health, split between two consortia of research institutions. The project was launched in July 2009 as the first of three Grand Challenges of the NIH's Blueprint for Neuroscience Research. On September 15, 2010, the NIH announced that it would award two grants: $30 million over five years to a consortium led by Washington University in Saint Louis and the University of Minnesota, with strong contributions from Oxford University (FMRIB) and $8.5 million over three years to a consortium led by Harvard University, Massachusetts General Hospital and the University of California Los Angeles.

Leiden Institute for Brain and Cognition

The Leiden Institute for Brain and Cognition or LIBC is an interfaculty center for interdisciplinary research on brain and cognition in the Netherlands. The Leiden University Medical Center and the Faculties of Humanities, Science and Social Behavioural Sciences of Leiden University participate in the LIBC. The LIBC research programs are presented in laboratories. There are different labs for all stages of the life span.

Neuroimaging intelligence testing concerns the use of neuroimaging techniques to evaluate human intelligence. Neuroimaging technology has advanced such that scientists hope to use neuroimaging increasingly for investigations of brain function related to IQ.

Russell Poldrack

Russell "Russ" Alan Poldrack is an American psychologist and neuroscientist. He is a professor of Psychology at Stanford University, Associate Director of Stanford Data Science, member of the Stanford Neuroscience Institute and director of the Stanford Center for Reproducible Neuroscience and the SDS Center for Open and Reproducible Science.

Richard (Rik) Henson is a Professor of Cognitive Neuroscience at the University of Cambridge, where he works at the MRC Cognition and Brain Sciences Unit in Cambridge, England. He studies the neural bases of human memory. From 2021 to 2022, he is also President of the British Neuroscience Society.

Alexander T. Sack is a German neuroscientist and cognitive psychologist. He is currently appointed as a full professor and chair of applied cognitive neuroscience at the Faculty of Psychology and Neuroscience at Maastricht University. He is also co-founder and board member of the Dutch-Flemish Brain Stimulation Foundation, director of the International Clinical TMS Certification Course, co-director of the Center for Integrative Neuroscience (CIN) and the Scientific Director of the Transcranial Brain Stimulation Policlinic at Maastricht University Medical Centre.

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