UBAP2

UBAP2
Identifiers
Aliases	UBAP2 , UBAP-2, ubiquitin associated protein 2
External IDs	MGI: 1916176 HomoloGene: 73649 GeneCards: UBAP2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	34,048,949 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	41,275,144 bp
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• RNA binding ; • cadherin binding ;
Cellular component	• nucleus ; • cytoplasm ;
Biological process	• positive regulation of gene expression ;
	Sources:Amigo / QuickGO
Orthologs
	55833
	68926
	ENSG00000137073
	ENSMUSG00000028433
	Q5T6F2
	Q91VX2
	NM_020867 ; NM_001282529 ; NM_001282530 ; NM_018449
	NM_026872
NP_001269459 ; NP_060919 ; NP_001356988 ; NP_001356991 ; NP_001356993 ;
	NP_001356995 ; NP_001356996 ; NP_001356997
	NP_081148
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 11, 2021

Ubiquitin-associated protein 2 is a protein that in humans is encoded by the UBAP2 gene.^[5]^[6]

Function

This gene is a novel gene isolated based on its expression in the human adrenal gland. The full-length protein encoded by this gene contains a UBA-domain (ubiquitin associated domain), which is a motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. In addition, the protein contains a region similar to a domain found in members of the atrophin-1 family. The function of this protein has not been determined. Additional alternate splice variants may exist, but their full length nature has not been determined.^[6]

Related Research Articles

Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological processes. This protein has been linked to X-linked spinal muscular atrophy type 2, neurodegenerative diseases, and cancers.

Cbl is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implicated in a number of human cancers, particularly acute myeloid leukaemia.

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.

E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.

Actin binding LIM protein 1, also known as ABLIM1, is a protein which in humans is encoded by the ABLIM1 gene.

Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.

Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene.

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.

ADAMTS-like protein 4 is a protein that in humans is encoded by the ADAMTSL4 gene.

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ARHGAP26 gene.

Ubiquitin-associated protein 2-like is a protein that in humans is encoded by the UBAP2L gene.

SH3 domain-binding protein 4 is a protein that in humans is encoded by the SH3BP4 gene.

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.

Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.

Pleckstrin homology domain-containing family A member 6 is a protein that in humans is encoded by the PLEKHA6 gene.

A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137073 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028433 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hofmann K, Bucher P (May 1996). "The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway". Trends in Biochemical Sciences. 21 (5): 172–3. doi:10.1016/S0968-0004(96)30015-7. PMID 8871400.
1 2 "Entrez Gene: UBAP2 ubiquitin associated protein 2".

Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267 . PMID 10737800.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID 10819331.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (September 2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Molecular & Cellular Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID 15951569.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137073 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028433 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8871400-5] Hofmann K, Bucher P (May 1996). "The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway". Trends in Biochemical Sciences. 21 (5): 172–3. doi:10.1016/S0968-0004(96)30015-7. PMID 8871400.

[entrez-6] 1 2 "Entrez Gene: UBAP2 ubiquitin associated protein 2".

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UBAP2

Contents

Function

Related Research Articles

References

Further reading