Una D. McCann

Last updated
Una Deirde McCann
Born1958
Citizenship American
Spouse George A. Ricaurte
Education
TitleDirector Anxiety Disorders Program

Associate Program Director JHBMC GCRC

Professor of Psychiatry and Behavioral Sciences

Professor of Neurology
Awards Phi Beta Kappa Society (1980)

Sigma Xi Award in Psychology (1980)

U.S. Army Commissioned Officers Award (1995)
Scientific career
FieldsPsychiatry
Institutions Johns Hopkins School of Medicine and Johns Hopkins Bayview Medical Center

Una D. McCann (born 1958) [1] is a board certified psychiatrist and researcher at Johns Hopkins School of Medicine in the Department of Psychiatry. [2] She is also the Director of the Anxiety Disorders Program, and Co-Director of the Center for Interdisciplinary Sleep Medicine and Research, and Associate Program Director at the Johns Hopkins Bayview Medical Center. [2] [3] McCann is considered to be an expert in anxiety and stress disorders and her primary areas research revolves around amphetamine-induced monoamine neurotoxicity [4] and neurobiology of anxiety disorders. [5] [6]

Contents

Education

McCann graduated from Princeton University in 1980 with a Bachelors of Science while on a four year academic scholarship. [7] After graduating, McCann went on to attended Duke University school of Medicine in 1984 and completed residency at Stanford University School of Medicine and Walter Reed Army Medical Center in 1988. [2] [3] In 1985, she became board certified in California and in 1990 in Maryland. [3]

Career

Prior to working at Johns Hopkins School of Medicine, McCann was a psychiatrist at Walter Reed Army Medical Center and was Chief of the Unit on Anxiety at the National Institute of Mental Health at the NIH. [6] Currently she is a practicing physician, professor of Neurology and Psychiatry, and holds many executive roles within Johns Hopkins School of Medicine and at Johns Hopkins Bayview Medical Center. [2] She is an editorial board member of the Journal of Women’s Health and Gender Based Medicine, Women in Medicine, Adicciones, Journal of Addiction, Journal of Sleep Disorders: Treatment and Care, WebmedCentral Plus, and Psychotherapy and Psychological Disorders and also holds a membership with the Society for Neuroscience, since 1988. [2]

MDMA research

McCann has written many research articles studying the effects of MDMA, including adverse reactions of MDMA and how it leads to serotonin neuron damage. [8] She and her husband, fellow Johns Hopkins Professor and Physician George A. Ricaurte, [9] have also linked abnormalities such as altered sleep, neuroendocrine function, altered behavior to 5-HT receptor drugs, and increased impulsiveness with MDMA users. [10] In addition, she has also done research on neurotoxicity MDMA using functional magnetic resonance imaging comparing the neurocognitive capabilities of MDMA users and nonusers, as studies on animals using MDMA have shown negative effects. [11] McCann and her husband Ricaurte have had one study published in the journal Science subject to retraction. In 2002, Ricaurte's primate study of MDMA usage and brain damage did not use ecstasy and that ten squirrel monkeys and baboons were injected with overdoses of methamphetamine, instead of MDMA, resulting in two animals dying and the withdrawal of four other academic papers. [12] [13] Ricaurte, McCann, and other scientist involved wrote a response to the retraction addressing the errors made in their research. [14]

Anxiety and stress research

McCann has been involved in a broad array of stress and anxiety research revolving around PTSD, depression, and traumatic brain injury. In regards to depression, McCann has worked on studying on the neuroanatomical markers of depression after traumatic brain injury through the use of diffusion tensor imaging (DTI) which measures the translational motion of water molecules and on individuals with depression after suffering from myocardial infarction. [15] [16] She has investigated assessing depression symptoms among patients hospitalized with acute myocardial infarction, coming to the conclusion that depression screening should be utilized in order to prevent depression among patients. [17] She has also been involved with associating a link between heart hart and posttraumatic stress disorders with severe burn patients. [18] McCann has investigated the association between mild traumatic brain injury and sleep disturbances through the use of sleep polysomnograms (PSG) and sleep EEG power spectra (PS), which could become a possible diagnostic marker for brain injury. [19]

Psilocybin research

McCann has been a part of psilocybin research, a naturally occurring psychedelic drug, in partnership with other Johns Hopkins scientist, including working with Roland Griffiths, [20] [21] who was featured on 60 Minutes regarding the studies done. [22] [23] The psilocybin research has focused on the mystical experiences associated with individuals taking psilocybin for religious purpose and observing the psychological effects. [20] McCann has also contributed to studies regarding psilocybin's use among cancer patients and healthy volunteers in two separate studies, investigating whether the use of this psychedelic increased psychological coping and decreased depression due to spirituality being associated with the two. [24]

Awards

McCann has published more than 140 peer-reviewed manuscripts and over 9,000 citations. [25]

Her awards include:

Related Research Articles

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"Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy")", is an article by George A. Ricaurte that was published in September 2002 in the peer-reviewed journal Science, one of the world's top academic journals. It was later retracted; instead of using MDMA, methamphetamine had been used in the test.

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References

  1. ↑ "Dr. Una McCann, MD | Baltimore, MD | Healthgrades". www.healthgrades.com. Retrieved 2020-11-18.
  2. 1 2 3 4 5 6 "Una D McCann, M.D., Professor of Psychiatry and Behavioral Sciences".
  3. 1 2 3 "Dr. Una McCann, MD – Baltimore, MD | Psychiatry on Doximity". Doximity. Retrieved 2020-11-17.
  4. ↑ McCann, Una D; Ricaurte, George A (2004-01-01). "Amphetamine neurotoxicity: accomplishments and remaining challenges". Neuroscience & Biobehavioral Reviews. Foundations and Innovations in the Neuroscience of Drug Abuse. 27 (8): 821–826. doi:10.1016/j.neubiorev.2003.11.003. ISSN   0149-7634. PMID   15019431. S2CID   24410018.
  5. ↑ "Alumni Profile: Una McCann '80, alleviating the effects of trauma". Princeton Alumni Weekly. 2009-09-23. Retrieved 2020-11-18.
  6. 1 2 "In the Ladies' Room with Dr. Donnica: 108: Post Traumatic Stress Disorder with Una D. McCann MD on Apple Podcasts". Apple Podcasts. Retrieved 2020-11-18.
  7. 1 2 "The Center for Mind-Body Research | Una McCann". Johns Hopkins Bloomberg School of Public Health. Retrieved 2020-11-17.
  8. ↑ McCann, Una D.; Slate, Shiyoko O.; Ricaurte, George A. (1996-08-01). "Adverse Reactions with 3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy')". Drug Safety. 15 (2): 107–115. doi:10.2165/00002018-199615020-00003. ISSN   1179-1942. PMID   8884162. S2CID   28491811.
  9. ↑ "George A Ricaurte, Jr, M.D., Ph.D., Professor of Neurology". Johns Hopkins Medicine. Retrieved 2020-11-29.
  10. ↑ McCann, Una D.; Eligulashvili, Victoria; Ricaurte, George A. (2000). "(±)3,4-Methylenedioxymethamphetamine ('Ecstasy')-Induced Serotonin Neurotoxicity: Clinical Studies". Neuropsychobiology. 42 (1): 11–16. doi:10.1159/000026665. ISSN   0302-282X. PMID   10867551. S2CID   37436219.
  11. ↑ Garg, Aayushi; Kapoor, Saloni; Goel, Mishita; Chopra, Saurav; Chopra, Manav; Kapoor, Anirudh; Behera, Chittaranjan; McCann, Una D. (2015-03-31). "Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review". Current Drug Abuse Reviews. 8 (1): 15–25. doi:10.2174/1874473708666150303115833. PMID   25731754 . Retrieved 2020-11-29.
  12. ↑ McNeil, Donald G. Jr (2003-12-02). "Research On Ecstasy Is Clouded By Errors (Published 2003)". The New York Times. ISSN   0362-4331 . Retrieved 2020-11-29.
  13. ↑ Holden, Constance (2003-09-12). "Paper on Toxic Party Drug Is Pulled Over Vial Mix-Up". Science. 301 (5639): 1454. doi:10.1126/science.301.5639.1454b. ISSN   0036-8075. PMID   12970527. S2CID   36895308.
  14. ↑ Ricaurte, George A.; Yuan, Jie; Hatzidimitriou, George; Cord, Branden J.; McCann, Una D. (2003-09-12). "Retraction". Science. 301 (5639): 1479. doi:10.1126/science.301.5639.1479b. ISSN   0036-8075. PMID   12970544. S2CID   220097819.
  15. ↑ Fauerbach, James A.; Bush, David E.; Thombs, Brett D.; McCann, Una D.; Fogel, Joshua; Ziegelstein, Roy C. (2005-07-01). "Depression Following Acute Myocardial Infarction: A Prospective Relationship With Ongoing Health and Function". Psychosomatics. 46 (4): 355–361. doi: 10.1176/appi.psy.46.4.355 . ISSN   0033-3182. PMID   16000679.
  16. ↑ Rao, Vani; Mielke, Michelle; Xu, Xin; Smith, Gwenn S.; McCann, Una D.; Bergey, Alyssa; Doshi, Vishal; Pham, Dzung L.; Yousem, David; Mori, Susumi (2012). "Diffusion Tensor Imaging Atlas-Based Analyses in Major Depression After Mild Traumatic Brain Injury". The Journal of Neuropsychiatry and Clinical Neurosciences. 24 (3): 309–315. doi:10.1176/appi.neuropsych.11080188. ISSN   0895-0172. PMC   5646269 . PMID   23037644.
  17. ↑ Ziegelstein, Roy C.; Kim, So Young; Kao, David; Fauerbach, James A.; Thombs, Brett D.; McCann, Una; Colburn, Jessica; Bush, David E. (2005). "Can Doctors and Nurses Recognize Depression in Patients Hospitalized With an Acute Myocardial Infarction in the Absence of Formal Screening?". Psychosomatic Medicine. 67 (3): 393–397. doi:10.1097/01.psy.0000160475.38930.8d. ISSN   0033-3174. PMID   15911901. S2CID   20873672.
  18. ↑ Gould, Neda F.; McKibben, Jodi B.; Hall, Ryan; Corry, Nida H.; Amoyal, Nicole A.; Mason, Shawn T.; McCann, Una D.; Fauerbach, James A. (2010-10-19). "Peritraumatic Heart Rate and Posttraumatic Stress Disorder in Patients With Severe Burns". The Journal of Clinical Psychiatry. 72 (4): 539–547. doi:10.4088/JCP.09m05405blu. ISSN   0160-6689. PMID   21034691.
  19. ↑ Rao, Vani; Bergey, Alyssa; Hill, Hugh; Efron, David; McCann, Una (2011-04-01). "Sleep Disturbance After Mild Traumatic Brain Injury: Indicator of Injury?". The Journal of Neuropsychiatry and Clinical Neurosciences. 23 (2): 201–205. doi:10.1176/jnp.23.2.jnp201. ISSN   0895-0172. PMID   21677251.
  20. 1 2 Griffiths, R. R.; Richards, W. A.; Johnson, M. W.; McCann, U. D.; Jesse, R. (2008-05-30). "Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later". Journal of Psychopharmacology. 22 (6): 621–632. doi:10.1177/0269881108094300. PMC   3050654 . PMID   18593735.
  21. ↑ Griffiths, Roland R.; Johnson, Matthew W.; Richards, William A.; Richards, Brian D.; McCann, Una; Jesse, Robert (2011-12-01). "Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects". Psychopharmacology. 218 (4): 649–665. doi:10.1007/s00213-011-2358-5. ISSN   1432-2072. PMC   3308357 . PMID   21674151.
  22. ↑ "'60 Minutes' segment explores psychedelics research at Johns Hopkins". The Hub. 2019-10-14. Retrieved 2020-12-04.
  23. ↑ "Psilocybin Sessions: Psychedelics could help people with addiction and anxiety". www.cbsnews.com. Retrieved 2020-12-04.
  24. ↑ "Psilocybin Studies: In Progress". MAPS. Retrieved 2020-12-04.
  25. ↑ "Una McCann ResearchGate Profile". ResearchGate . Retrieved 28 November 2020.
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