ZNF268

ZNF268
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2EL4, 2EL5, 2EL6, 2EM1, 2EMV, 2EMW, 2EMX, 2EMY, 2EN0, 2EN6, 2EN7, 2EOF, 2EOG, 2EOI, 2EOJ, 2EOK, 2EOL, 2EOP, 2EPV, 2EPW, 2EPY, 2YTF, 2YTQ
Identifiers
Aliases	ZNF268 , HZF3, zinc finger protein 268
External IDs	OMIM: 604753 HomoloGene: 124392 GeneCards: ZNF268
Gene location (Human)
Chr.	Chromosome 12 (human)
End	133,214,832 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; retinal pigment epithelium; ; islet of Langerhans; ; stromal cell of endometrium; ; oocyte; ; palpebral conjunctiva; ; secondary oocyte; ; visceral pleura; ; germinal epithelium;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleic acid binding ; DNA binding ; DNA-binding transcription factor activity ; metal ion binding ; protein binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	intracellular anatomical structure ; cytoplasm ; actin cytoskeleton ; nucleus ; cytosol ;
Biological process	regulation of transcription, DNA-templated ; cell differentiation ; positive regulation of protein phosphorylation ; positive regulation of protein catabolic process ; regulation of protein heterodimerization activity ; positive regulation of cell migration ; cellular response to tumor necrosis factor ; negative regulation of apoptotic process ; negative regulation of transcription by RNA polymerase II ; positive regulation of protein homodimerization activity ; transcription, DNA-templated ; positive regulation of cell differentiation ; positive regulation of cell population proliferation ; regulation of mitotic cell cycle ; positive regulation of apoptotic process ; negative regulation of cell population proliferation ; positive regulation of transcription by RNA polymerase II ; positive regulation of NIK/NF-kappaB signaling ;
	Sources:Amigo / QuickGO
Orthologs
	10795
	n/a
	ENSG00000090612
	n/a
	Q14587
	n/a
NM_152943 ; NM_001165881 ; NM_001165882 ; NM_001165883 ; NM_001165884 ;
	NM_001165885 ; NM_001165886 ; NM_001165887 ; NM_003415
	n/a
NP_001159353 ; NP_001159354 ; NP_001159355 ; NP_001159356 ; NP_001159357 ;
	NP_001159358 ; NP_001159359 ; NP_003406 ; NP_694422
	n/a
	Wikidata
View/Edit Human

Last updated October 22, 2023

Zinc finger protein 268 is a protein that in humans is encoded by the ZNF268 gene.^[3]^[4] ZNF268 is associated with cervical cancer.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000090612 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Abrink M, Aveskogh M, Hellman L (Mar 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
↑ "Entrez Gene: ZNF268 zinc finger protein 268".

Shao H, Zhu C, Zhao Z, et al. (2006). "KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains". Int. J. Mol. Med. 18 (3): 457–63. doi: 10.3892/ijmm.18.3.457 . PMID 16865230.
Guo MX, Wang D, Shao HJ, et al. (2006). "Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element". J. Biol. Chem. 281 (34): 24623–36. doi: 10.1074/jbc.M602753200 . PMID 16787922.
Sun Y, Shao H, Li Z, et al. (2005). "ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development". Int. J. Mol. Med. 14 (6): 971–5. doi:10.3892/ijmm.14.6.971. PMID 15547661.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Sun Y, Gou DM, Liu H, et al. (2004). "The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor". IUBMB Life. 55 (3): 127–31. doi: 10.1080/1521654031000110208 . PMID 12822888. S2CID 43391168.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gou DM, Sun Y, Gao L, et al. (2001). "Cloning and characterization of a novel Krüppel-like zinc finger gene, ZNF268, expressed in early human embryo". Biochim. Biophys. Acta. 1518 (3): 306–10. doi:10.1016/s0167-4781(01)00194-4. hdl: 10397/34032 . PMID 11311945.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000090612 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7865130-3] Abrink M, Aveskogh M, Hellman L (Mar 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.

[entrez-4] "Entrez Gene: ZNF268 zinc finger protein 268".

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ZNF268

Related Research Articles

References

Further reading