Atypical anorexia nervosa

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Atypical anorexia nervosa is an eating disorder in which individuals meet all the qualifications for anorexia nervosa, including a body image disturbance and a history of restrictive eating and weight loss, except that they are not currently underweight. [1] Atypical anorexia qualifies as a mental health disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), under the category Other Specified Feeding and Eating Disorders (OSFED). [2] The characteristics of people with atypical anorexia generally do not differ significantly from anorexia nervosa patients except for their current weight. [3]

Contents

Atypical anorexia was not described in earlier editions of the DSM, which included a requirement that person to have a body weight no higher than 85% of normal. [4] Patients with atypical anorexia were diagnosed with the DSM-4 qualification "eating disorder not otherwise specified" (EDNOS) until the DSM-5 was released in 2013. [4] Prior to DSM-5, EDNOS made up the majority of eating disorders diagnoses, making it difficult to estimate the prevalence of atypical anorexia during this period. [4] The term atypical anorexia was historically used to describe the restrictive eating habits of some people with autism. The DSM-5 superseded this term with the avoidant restrictive food intake disorder (ARFID) diagnosis. [4]

Signs and symptoms

Many of the physical symptoms of atypical anorexia nervosa are due to the effects of decreased caloric intake which causes the body to significantly suppress the metabolic rate. [4] The body's decreased metabolic rate is a response to stress and causes widespread symptoms that affect many of the organ systems as the body is attempting to adjust to its malnourished state. This causes hypo metabolic symptoms such as chronic fatigue, bradycardia, and amenorrhea. [4] Bradycardia and orthostatic instability are frequent and life-threatening complications that account for the majority of medical hospitalizations in atypical anorexia nervosa. [4]

Physical Symptoms

- Amenorrhea [5]

- Rapid, continuous weight loss

Psychiatric and metabolic traits associated with anorexia nervosa Association of Anorexia nervosa with psychiatric and metabolic traits.jpg
Psychiatric and metabolic traits associated with anorexia nervosa

- Bradycardia [6]

- Orthostatic instability [6]

- Chronic fatigue

- Halitosis

- Hypotension [5]

- Slowed gastric emptying [5]

- Insomnia

- Anemia [5]

- Yellowing and/or drying skin

While patients have many similar physical symptoms, there are physical symptoms that may be absent or less frequent in atypical anorexia nervosa as compared to typical anorexia nervosa such as lanugo hair. [7] These symptoms often are attributed to low body weight which is not seen in atypical anorexia nervosa.

Psychiatric/Cognitive Symptoms

- Intense fear of gaining weight or becoming fat

Depression is one of the most common co-morbidities associated with atypical anorexia nervosa. Depression-loss of loved one.jpg
Depression is one of the most common co-morbidities associated with atypical anorexia nervosa.

- Disturbance in the way in which one's body weight or shape is experienced, undue influence of body weight or shape on self-evaluation.

- Obsessive and compulsive symptoms [8]

- Anxiety [8]

- Depression

- Somatization [8]

- Social phobia [8]

It is common for patients with atypical anorexia nervosa to have co-morbid psychiatric disorders such as depression, anxiety, and OCD. [4] Depressive and anxious disorders account for the majority of the comorbid disorders seen in association with atypical anorexia nervosa. [4] However, there are limited studies on the prevalence of psychiatric illness in atypical anorexia nervosa.

Treatment

The methodologies used by eating disorder treatment centers to treat anorexia nervosa generally also help those affected by atypical anorexia. Re-feeding and addressing any possible electrolyte imbalances is usually the first step in treating atypical anorexia nervosa, as complications from underlying electrolyte imbalances and malnutrition can be fatal. [6] A calorie range of 1000-1400 kcal is recommended when first starting treatment for anorexia nervosa or atypical anorexia nervosa as the patient's body might not be accustomed to a higher caloric range. [4] It is recommended that they are treated in an inpatient facility and slowly adjusted to increased calorie intake by 100-200 additional calories per day. In addition to addressing malnutrition, healthy, moderate weight gain is the goal of early treatment and the patient should be monitored for a lack of weight gain or rapid weight gain which can indicate re-feeding syndrome. [4]

Treatment may also include a variety of therapies that help a patient deal with the depression, anxiety, and other mental symptoms that arise from the eating disorder. [4] In addition to addressing caloric intake and malnutrition, psychological treatment of patients is vital to treatment of atypical anorexia nervosa. Psychotherapy including cognitive behavioral therapy, dialectical behavioral therapy, and interpersonal therapy are used frequently in the treatment of atypical anorexia nervosa. [4] However, only family therapy has shown real efficacy in treating patients with anorexia nervosa and atypical anorexia nervosa. [4] Overall, studies on the efficacy of psychotherapy in atypical anorexia nervosa are limited at this time.

Psychiatric medications are used as an adjunct to mainstay treatments of atypical anorexia nervosa and have limited efficacy in the treatment of this disease. [4] In anorexia nervosa, patients who are severely malnourished see very little improvement with selective serotonin reuptake inhibitors (SSRIs) and no studies have indicated improvement in atypical anorexia nervosa with SSRIs. [5] Due to this, SSRIs have a limited role in the treatment of atypical anorexia nervosa. [4]

In the US, treatment may be complicated by the need to get health insurance plans to pay. Medical coding may be incorrect on requests or may be rejected because payers incorrectly evaluated it under the separate criteria for anorexia nervosa. [9]

Diagnosis

The diagnosis of atypical anorexia nervosa is carried out by a licensed health practitioner based on a clinical assessment which includes physical, psychiatric, and behavioral symptoms.

DSM-5 Criteria

The diagnostic criteria used to diagnose psychiatric conditions are found in the Diagnostic and Statistical Manual of Mental Disorders (DSM) published by the American Psychiatric Association. The DSM-5 is the most current revision of the manual which was updated in 2013 to include atypical anorexia nervosa. This update addressed problems pointed out by the psychiatric community that the eating disorder section of the DSM-4 did not properly address the segment of patients who met many of the criteria of typical anorexia nervosa but did not meet the weight requirement of typical anorexia nervosa. [7] Many of these patients were left without a specific diagnosis while dealing with an eating disorder that did not fit any criteria. [7] Due to this, the DSM-5 included descriptions of disorders that did not meet criteria but created significant impairment in a patient's daily life. [7] These disorders are found in the "Other specified feeding or eating disorders" or OSFED.

According to the DSM-5, in the "Other specified feeding or eating disorders", atypical anorexia nervosa is defined as "all of the criteria for anorexia nervosa are met, except that despite significant weight loss, the individual's weight is within or above the normal range." There is no consensus in the psychiatric community about what constitutes "significant weight loss" and there are calls from the psychiatric community that this be researched and addressed in subsequent DSM publications. [7]

Prognosis

Anorexia nervosa is one of the most difficult psychiatric disorders to treat and has a high mortality rate due to complications from malnutrition and suicide. [4] Currently there are no specific studies completed on the prognosis of atypical anorexia nervosa. However, the current consensus is that it is similar to, if not worse, than that of anorexia nervosa. [4] One study looked at the length of duration of individual episodes seen in patients and found atypical anorexia nervosa had an 11.2 month duration as compared to anorexia nervosa with an 8-month duration. [4] Overall, the remission rates of atypical anorexia nervosa and anorexia nervosa are similar at 71% for atypical anorexia nervosa and 75% for anorexia nervosa. [4]

The current consensus is that atypical anorexia patients are at risk for many of the same medical complications of anorexia nervosa. [4] Evidence from a study conducted at the University of California San Francisco Eating Disorders Program suggests that atypical anorexia patients are equally likely as anorexia nervosa patients to develop secondary side effects related to decreased caloric and nutritional intake, including bradycardia (decreased heart rate), amenorrhea (stopping of the menstrual period), and electrolyte imbalances. [10]

Epidemiology

It is difficult to gauge the true prevalence of atypical anorexia pre-2013 because patients were lumped together under the EDNOS diagnosis. [4] Evidence suggests that atypical anorexia is more prevalent than anorexia nervosa, but individuals experiencing it are less likely to receive care. [11] For example, one prospective study of 196 women found a prevalence of 2.8% for atypical anorexia, compared to only 0.8% for anorexia nervosa by the age of 20. [12] However, individuals experiencing atypical anorexia nervosa are less likely to receive care. In addition, when these individuals do receive care, there is a higher rate of treatment dropout and decreased treatment response. [8] This can be attributed to a number of reasons including less stigma surrounding atypical anorexia nervosa due to patients in the normal or overweight range, as well as the perception of patients that the severity of their eating disorder is low because of their weight range. [8]

Related Research Articles

An eating disorder is a mental disorder defined by abnormal eating behaviors that negatively affect a person's physical or mental health. Types of eating disorders include binge eating disorder, where the patient eats a large amount in a short period of time; anorexia nervosa, where the person has an intense fear of gaining weight and restricts food or overexercises to manage this fear; bulimia nervosa, where individuals eat a large quantity (binging) then try to rid themselves of the food (purging); pica, where the patient eats non-food items; rumination syndrome, where the patient regurgitates undigested or minimally digested food; avoidant/restrictive food intake disorder (ARFID), where people have a reduced or selective food intake due to some psychological reasons; and a group of other specified feeding or eating disorders. Anxiety disorders, depression and substance abuse are common among people with eating disorders. These disorders do not include obesity. People often experience comorbidity between an eating disorder and OCD. It is estimated 20–60% of patients with an ED have a history of OCD.

<span class="mw-page-title-main">Bulimia nervosa</span> Type of eating disorder

Bulimia nervosa, also known as simply bulimia, is an eating disorder characterized by binge eating followed by purging or fasting, and excessive concern with body shape and weight. This activity aims to expel the body of calories eaten from the binging phase of the process. Binge eating refers to eating a large amount of food in a short amount of time. Purging refers to the attempts to get rid of the food consumed. This may be done by vomiting or taking laxatives.

Orthorexia nervosa (ON) is a proposed eating disorder characterized by an excessive preoccupation with eating healthy food. The term was introduced in 1997 by American physician Steven Bratman, M.D. He suggested that some people's dietary restrictions intended to promote health may paradoxically lead to unhealthy consequences, such as social isolation; anxiety; loss of ability to eat in a natural, intuitive manner; reduced interest in the full range of other healthy human activities; and, in rare cases, severe malnutrition or even death.

<span class="mw-page-title-main">Obsessive–compulsive personality disorder</span> Personality disorder involving orderliness

Obsessive–compulsive personality disorder (OCPD) is a cluster C personality disorder marked by a spectrum of obsessions with rules, lists, schedules, and order, among other things. Symptoms are usually present by the time a person reaches adulthood, and are visible in a variety of situations. The cause of OCPD is thought to involve a combination of genetic and environmental factors, namely problems with attachment.

Binge eating disorder (BED) is an eating disorder characterized by frequent and recurrent binge eating episodes with associated negative psychological and social problems, but without the compensatory behaviors common to bulimia nervosa, OSFED, or the binge-purge subtype of anorexia nervosa.

Binge eating is a pattern of disordered eating which consists of episodes of uncontrollable eating. It is a common symptom of eating disorders such as binge eating disorder and bulimia nervosa. During such binges, a person rapidly consumes an excessive quantity of food. A diagnosis of binge eating is associated with feelings of loss of control. Binge eating disorder is also linked with being overweight and obesity.

Unspecified feeding or eating disorder (UFED) is a DSM-5 category of eating disorders that, along with other specified feeding or eating disorder (OSFED), replaced eating disorder not otherwise specified (EDNOS) in the DSM-IV-TR.

Anorexia athletica, also referred to as hyper-gymnasia, is an eating disorder characterized by excessive and compulsive exercise. An athlete with sports anorexia tends to overexercise to give themselves a sense of having control over their body. Most often, people with the disorder tend to feel they have no control over their lives other than their control of food and exercise. In actuality, they have no control; they cannot stop exercising or regulating food intake without feeling guilty. Generally, once the activity is started, it is difficult to stop because the person is seen as being addicted to the method adopted.

<span class="mw-page-title-main">Relative energy deficiency in sport</span> Syndrome of disordered eating, oligomenorrhoea and osteopenia

Relative energy deficiency in sport (RED-S) is a syndrome in which disordered eating, amenorrhoea/oligomenorrhoea, and decreased bone mineral density are present. It is caused by eating too little food to support the amount of energy being expended by an athlete, often at the urging of a coach or other authority figure who believes that athletes are more likely to win competitions when they have an extremely lean body type. RED-S is a serious illness with lifelong health consequences and can potentially be fatal.

The Eating Attitudes Test, created by David Garner, is a widely used 26-item, standardized self-reported questionnaire of symptoms and concerns characteristic of eating disorders. The EAT is useful in assessing "eating disorder risk" in high school, college and other special risk samples such as athletes. EAT has been extremely effective in screening for anorexia nervosa in many populations.

Avoidant/restrictive food intake disorder (ARFID) is a feeding or eating disorder in which people avoid eating certain foods, or restrict their diets to the point it ultimately results in nutritional deficiencies. This can be due to the sensory characteristics of food, such as its appearance, smell, texture, or taste, and/or due to fear of negative consequences such as choking or vomiting; and/or having little interest in eating or food. People with ARFID may also be afraid of trying new foods, a fear known as food neophobia.

<span class="mw-page-title-main">DSM-5</span> 2013 edition of the Diagnostic and Statistical Manual of Mental Disorders

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), is the 2013 update to the Diagnostic and Statistical Manual of Mental Disorders, the taxonomic and diagnostic tool published by the American Psychiatric Association (APA). In 2022, a revised version (DSM-5-TR) was published. In the United States, the DSM serves as the principal authority for psychiatric diagnoses. Treatment recommendations, as well as payment by health care providers, are often determined by DSM classifications, so the appearance of a new version has practical importance. However, not all providers rely on the DSM-5 for planning treatment as the ICD's mental disorder diagnoses are used around the world and scientific studies often measure changes in symptom scale scores rather than changes in DSM-5 criteria to determine the real-world effects of mental health interventions. The DSM-5 is the only DSM to use an Arabic numeral instead of a Roman numeral in its title, as well as the only living document version of a DSM.

Diabulimia, also known as ED-DMT1 in the US or T1ED in the UK, is an eating disorder in which people with type 1 diabetes deliberately give themselves less insulin than they need or stop taking it altogether for the purpose of weight loss. Diabulimia is not recognized as a formal psychiatric diagnosis in the DSM-5. Because of this, some in the medical or psychiatric communities use the phrases "disturbed eating behavior" or "disordered eating behavior" and disordered eating (DE) are quite common in medical and psychiatric literature addressing patients who have type 1 diabetes and manipulate insulin doses to control weight along with exhibiting bulimic behavior.

Purging disorder is an eating disorder characterized by the DSM-5 as self-induced vomiting, or misuse of laxatives, diuretics, or enemas to forcefully evacuate matter from the body. Purging disorder differs from bulimia nervosa (BN) because individuals do not consume a large amount of food before they purge. In current diagnostic systems, purging disorder is a form of other specified feeding or eating disorder. Research indicates that purging disorder, while not rare, is not as commonly found as anorexia nervosa or bulimia nervosa. This syndrome is associated with clinically significant levels of distress, and that it appears to be distinct from bulimia nervosa on measures of hunger and ability to control food intake. Some of the signs of purging disorder are frequent trips to the bathroom directly after a meal, frequent use of laxatives, and obsession over one's appearance and weight. Other signs include swollen cheeks, popped blood vessels in the eyes, and clear teeth which are all signs of excessive vomiting.

Functional hypothalamic amenorrhea (FHA) is a form of amenorrhea and chronic anovulation and is one of the most common types of secondary amenorrhea. It is classified as hypogonadotropic hypogonadism. It was previously known as "juvenile hypothalamosis syndrome," prior to the discovery that sexually mature females are equally affected. FHA has multiple risk factors, with links to stress-related, weight-related, and exercise-related factors. FHA is caused by stress-induced suppression of the hypothalamic-pituitary-ovarian (HPO) axis, which results in inhibition of gonadotropin-releasing hormone (GnRH) secretion, and gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Severe and potentially prolonged hypoestrogenism is perhaps the most dangerous hormonal pathology associated with the disease, because consequences of this disturbance can influence bone health, cardiovascular health, mental health, and metabolic functioning in both the short and long-term. Because many of the symptoms overlap with those of organic hypothalamic, pituitary, or gonadal disease and therefore must be ruled out, FHA is a diagnosis of exclusion; "functional" is used to indicate a behavioral cause, in which no anatomical or organic disease is identified, and is reversible with correction of the underlying cause. Diagnostic workup includes a detailed history and physical, laboratory studies, such as a pregnancy test, and serum levels of FSH and LH, prolactin, and thyroid-stimulating hormone (TSH), and imaging. Additional tests may be indicated in order to distinguish FHA from organic hypothalamic or pituitary disorders. Patients present with a broad range of symptoms related to severe hypoestrogenism as well as hypercortisolemia, low serum insulin levels, low serum insulin-like growth factor 1 (IGF-1), and low total triiodothyronine (T3). Treatment is primarily managing the primary cause of the FHA with behavioral modifications. While hormonal-based therapies are potential treatment to restore menses, weight gain and behavioral modifications can have an even more potent impact on reversing neuroendocrine abnormalities, preventing further bone loss, and re-establishing menses, making this the recommended line of treatment. If this fails to work, secondary treatment is aimed at treating the effects of hypoestrogenism, hypercortisolism, and hypothyroidism.

<span class="mw-page-title-main">Anorexia nervosa</span> Type of eating disorder

Anorexia nervosa (AN), often referred to simply as anorexia, is an eating disorder characterized by low weight, food restriction, body image disturbance, fear of gaining weight, and an overpowering desire to be thin.

The differential diagnoses of anorexia nervosa (AN) includes various types of medical and psychological conditions, which may be misdiagnosed as AN. In some cases, these conditions may be comorbid with AN because the misdiagnosis of AN is not uncommon. For example, a case of achalasia was misdiagnosed as AN and the patient spent two months confined to a psychiatric hospital. A reason for the differential diagnoses that surround AN arise mainly because, like other disorders, it is primarily, albeit defensively and adaptive for, the individual concerned. Anorexia Nervosa is a psychological disorder characterized by extremely reduced intake of food. People with anorexia nervosa have a low self-image and consider themselves overweight.

Cognitive behavioral therapy (CBT) is derived from both the cognitive and behavioral schools of psychology and focuses on the alteration of thoughts and actions with the goal of treating various disorders. The cognitive behavioral treatment of eating disorders emphasizes on the minimization of negative thoughts about body image and the act of eating, and attempts to alter negative and harmful behaviors that are involved in and perpetuate eating disorders. It also encourages the ability to tolerate negative thoughts and feelings as well as the ability to think about food and body perception in a multi-dimensional way. The emphasis is not only placed on altering cognition, but also on tangible practices like making goals and being rewarded for meeting those goals. CBT is a "time-limited and focused approach" which means that it is important for the patients of this type of therapy to have particular issues that they want to address when they begin treatment. CBT has also proven to be one of the most effective treatments for eating disorders.

Other specified feeding or eating disorder (OSFED) is a subclinical DSM-5 category that, along with unspecified feeding or eating disorder (UFED), replaces the category formerly called eating disorder not otherwise specified (EDNOS) in the DSM-IV-TR. It captures feeding disorders and eating disorders of clinical severity that do not meet diagnostic criteria for anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder (BED), avoidant/restrictive food intake disorder (ARFID), pica, or rumination disorder. OSFED includes five examples:

Body image disturbance (BID) is a common symptom in patients with eating disorders and is characterized by an altered perception of one's own body.

References

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