CRKL

Last updated
CRKL
Protein CRKL PDB 2bzx.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CRKL , CRK like proto-oncogene, adaptor protein
External IDs OMIM: 602007 MGI: 104686 HomoloGene: 38021 GeneCards: CRKL
Orthologs
SpeciesHumanMouse
Entrez

1399

12929

Ensembl

ENSG00000099942

ENSMUSG00000006134

UniProt

P46109

P47941

RefSeq (mRNA)

NM_005207

NM_001277231
NM_007764

RefSeq (protein)

NP_005198

NP_001264160
NP_031790

Location (UCSC) Chr 22: 20.92 – 20.95 Mb Chr 16: 17.27 – 17.31 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Crk-like protein is a protein that in humans is encoded by the CRKL gene. [5] [6]

Contents

Function

v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. [7]

CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1. [8] [9]

Interactions

CRKL has been shown to interact with:

See also

Related Research Articles

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Ravi Salgia is a translational thoracic oncologist, clinician/scientist, and academician.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000099942 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006134 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ ten Hoeve J, Morris C, Heisterkamp N, Groffen J (September 1993). "Isolation and chromosomal localization of CRKL, a human crk-like gene". Oncogene. 8 (9): 2469–74. PMID   8361759.
  6. ↑ Senechal K, Halpern J, Sawyers CL (September 1996). "The CRKL adaptor protein transforms fibroblasts and functions in transformation by the BCR-ABL oncogene". The Journal of Biological Chemistry. 271 (38): 23255–61. doi: 10.1074/jbc.271.38.23255 . PMID   8798523.
  7. ↑ "Entrez Gene: CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like".
  8. ↑ Matsuki T, Pramatarova A, Howell BW (June 2008). "Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis". Journal of Cell Science. 121 (11): 1869–75. doi:10.1242/jcs.027334. PMC   2430739 . PMID   18477607.
  9. ↑ Park TJ, Curran T (December 2008). "Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway". The Journal of Neuroscience. 28 (50): 13551–62. doi:10.1523/JNEUROSCI.4323-08.2008. PMC   2628718 . PMID   19074029.
  10. 1 2 3 4 Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL (November 1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)". Journal of Immunology. 161 (10): 5555–63. doi:10.4049/jimmunol.161.10.5555. PMID   9820532.
  11. 1 2 Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ (January 1997). "Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation". Blood. 89 (1): 297–306. doi: 10.1182/blood.V89.1.297 . PMID   8978305.
  12. ↑ Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites". Genes & Development. 8 (7): 783–95. doi: 10.1101/gad.8.7.783 . PMID   7926767.
  13. ↑ Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD (October 1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". The Journal of Biological Chemistry. 271 (41): 25198–203. doi: 10.1074/jbc.271.41.25198 . PMID   8810278.
  14. 1 2 Astier A, Manié SN, Law SF, Canty T, Haghayghi N, Druker BJ, Salgia R, Golemis EA, Freedman AS (December 1997). "Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells". Leukemia & Lymphoma. 28 (1–2): 65–72. doi:10.3109/10428199709058332. PMID   9498705.
  15. ↑ Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941–8. doi:10.1038/sj.onc.1202024. PMID   9747873. S2CID   20866214.
  16. ↑ Kolibaba KS, Bhat A, Heaney C, Oda T, Druker BJ (March 1999). "CRKL binding to BCR-ABL and BCR-ABL transformation". Leukemia & Lymphoma. 33 (1–2): 119–26. doi:10.3109/10428199909093732. PMID   10194128.
  17. ↑ Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA (June 2004). "A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase". Molecular and Cellular Biology. 24 (11): 4685–95. doi:10.1128/MCB.24.11.4685-4695.2004. PMC   416425 . PMID   15143164.
  18. ↑ Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC (February 1999). "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation". Oncogene. 18 (5): 1147–56. doi:10.1038/sj.onc.1202411. PMID   10022120. S2CID   25964785.
  19. ↑ van Dijk TB, van Den Akker E, Amelsvoort MP, Mano H, Löwenberg B, von Lindern M (November 2000). "Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells". Blood. 96 (10): 3406–13. doi:10.1182/blood.V96.10.3406. PMID   11071635.
  20. 1 2 3 Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)". The Journal of Biological Chemistry. 272 (15): 10248–53. doi: 10.1074/jbc.272.15.10248 . PMID   9092574.
  21. ↑ Felschow DM, McVeigh ML, Hoehn GT, Civin CI, Fackler MJ (June 2001). "The adapter protein CrkL associates with CD34". Blood. 97 (12): 3768–75. doi: 10.1182/blood.v97.12.3768 . PMID   11389015.
  22. 1 2 3 Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O (October 1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochemical and Biophysical Research Communications. 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. PMID   9344843.
  23. ↑ Alsayed Y, Modi S, Uddin S, Mahmud N, Druker BJ, Fish EN, Hoffman R, Platanias LC (July 2000). "All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells". Experimental Hematology. 28 (7): 826–32. doi:10.1016/s0301-472x(00)00170-3. PMID   10907644.
  24. ↑ Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation". International Immunology. 13 (1): 13–22. doi: 10.1093/intimm/13.1.13 . PMID   11133830.
  25. ↑ Park RK, Kyono WT, Liu Y, Durden DL (May 1998). "CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling". Journal of Immunology. 160 (10): 5018–27. doi:10.4049/jimmunol.160.10.5018. PMID   9590251.
  26. ↑ Taher TE, Tjin EP, Beuling EA, Borst J, Spaargaren M, Pals ST (October 2002). "c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination". Journal of Immunology. 169 (7): 3793–800. doi: 10.4049/jimmunol.169.7.3793 . PMID   12244174.
  27. ↑ Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL (April 1999). "Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages". Journal of Leukocyte Biology. 65 (4): 523–34. doi:10.1002/jlb.65.4.523. PMID   10204582. S2CID   18340540.
  28. 1 2 Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD (May 1997). "Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1)". The Journal of Biological Chemistry. 272 (22): 14320–6. doi: 10.1074/jbc.272.22.14320 . PMID   9162067.
  29. ↑ Gesbert F, Garbay C, Bertoglio J (February 1998). "Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells". The Journal of Biological Chemistry. 273 (7): 3986–93. doi: 10.1074/jbc.273.7.3986 . PMID   9461587.
  30. ↑ Nishihara H, Maeda M, Oda A, Tsuda M, Sawa H, Nagashima K, Tanaka S (December 2002). "DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines". Blood. 100 (12): 3968–74. doi: 10.1182/blood-2001-11-0032 . PMID   12393632.
  31. 1 2 Arai A, Kanda E, Nosaka Y, Miyasaka N, Miura O (August 2001). "CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling". The Journal of Biological Chemistry. 276 (35): 33282–90. doi: 10.1074/jbc.M102924200 . PMID   11443118.
  32. 1 2 Sakkab D, Lewitzky M, Posern G, Schaeper U, Sachs M, Birchmeier W, Feller SM (April 2000). "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry. 275 (15): 10772–8. doi: 10.1074/jbc.275.15.10772 . PMID   10753869.
  33. ↑ Crouin C, Arnaud M, Gesbert F, Camonis J, Bertoglio J (April 2001). "A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners". FEBS Letters. 495 (3): 148–53. doi:10.1016/s0014-5793(01)02373-0. PMID   11334882. S2CID   24499468.
  34. ↑ Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM (October 1998). "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene. 17 (15): 1893–901. doi:10.1038/sj.onc.1202108. PMID   9788432. S2CID   19885101.
  35. ↑ Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH (February 1999). "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Molecular and Cellular Biology. 19 (2): 1359–68. doi:10.1128/MCB.19.2.1359. PMC   116064 . PMID   9891069.
  36. ↑ Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH (June 2001). "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". The Journal of Biological Chemistry. 276 (22): 18908–14. doi: 10.1074/jbc.M101485200 . PMID   11279207.
  37. ↑ Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation". Blood. 95 (3): 776–82. doi:10.1182/blood.V95.3.776.003k23_776_782. PMID   10648385. S2CID   22593342.
  38. ↑ Manié SN, Beck AR, Astier A, Law SF, Canty T, Hirai H, Druker BJ, Avraham H, Haghayeghi N, Sattler M, Salgia R, Griffin JD, Golemis EA, Freedman AS (February 1997). "Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells". The Journal of Biological Chemistry. 272 (7): 4230–6. doi: 10.1074/jbc.272.7.4230 . PMID   9020138.
  39. ↑ Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB (December 1995). "CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells". The Journal of Biological Chemistry. 270 (49): 29145–50. doi: 10.1074/jbc.270.49.29145 . PMID   7493940.
  40. ↑ Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K (August 2001). "Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase". Molecular and Cellular Biology. 21 (16): 5332–45. doi:10.1128/MCB.21.16.5332-5345.2001. PMC   87257 . PMID   11463817.
  41. ↑ Grumbach IM, Mayer IA, Uddin S, Lekmine F, Majchrzak B, Yamauchi H, Fujita S, Druker B, Fish EN, Platanias LC (February 2001). "Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells". British Journal of Haematology. 112 (2): 327–36. doi: 10.1046/j.1365-2141.2001.02556.x . PMID   11167825.
  42. ↑ Ahmad S, Alsayed YM, Druker BJ, Platanias LC (November 1997). "The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein". The Journal of Biological Chemistry. 272 (48): 29991–4. doi: 10.1074/jbc.272.48.29991 . PMID   9374471.
  43. ↑ Smit L, van der Horst G, Borst J (April 1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". The Journal of Biological Chemistry. 271 (15): 8564–9. doi: 10.1074/jbc.271.15.8564 . PMID   8621483.
  44. ↑ Wu C, Lai CF, Mobley WC (August 2001). "Nerve growth factor activates persistent Rap1 signaling in endosomes". The Journal of Neuroscience. 21 (15): 5406–16. doi: 10.1523/JNEUROSCI.21-15-05406.2001 . PMC   6762651 . PMID   11466412.
  45. ↑ Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Molecular and Cellular Biology. 22 (24): 8721–34. doi:10.1128/mcb.22.24.8721-8734.2002. PMC   139861 . PMID   12446789.
  46. ↑ Ota J, Kimura F, Sato K, Wakimoto N, Nakamura Y, Nagata N, Suzu S, Yamada M, Shimamura S, Motoyoshi K (November 1998). "Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage colony-stimulating factor or erythropoietin". Biochemical and Biophysical Research Communications. 252 (3): 779–86. doi:10.1006/bbrc.1998.9445. PMID   9837784.
  47. 1 2 Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H (May 2001). "CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk". Blood. 97 (9): 2633–9. doi: 10.1182/blood.v97.9.2633 . PMID   11313252.

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