Endoexoenteric

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Endoexoenteric refers to a specific radiographic manifestation of lymphoma of the bowel.

Contents

Lymphoma

Lymphomas are malignant neoplasms (cancers) arising from lymphocytes of the immune system. When they arise in the bowel tissue, they are referred to as primary. In other instances, the tumor can arise from the lymph nodes and "travel" to the bowel, so-called "extra-nodal" disease.[ citation needed ]

"Endoexoenteric"

Origin of Term

Marshak [1] was the first to introduce the term "endoexoenteric" to refer to a specific radiographic pattern (seen on x-rays, CT scans or PET scans) of lymphomatous involvement of the bowel. This terminology derives from the fact that in this form of lymphomatous invasion of the bowel, the tumor extends throughout the entire width of the bowel wall, from the luminal or mucosal (endo) surface to the serosal (exo) surface. Enteric refers to the bowel itself. In Marshak's later textbook, published in 1980, [2] he abandons this terminology.

Presentation

Of the five patterns of bowel lymphoma described in Marshak's original work, endoexoenteric is the second most common type (the others being: infiltrative [most common], multiple nodules, polypoidal mass, and mesenteric.) [3] [4]

Features

Specifically, the features of endoexoenteric lymphoma are an irregular collection of barium due to central ulceration, and displacement of adjacent bowel loops. In this form of lymphoma, fistula formation (an abnormal communication between the tumor and adjacent bowel loops) is common. Since the bowel is not sterile, infection can easily be introduced, leading to findings of mesenteric abscesses. [5] [6]

Diagnosis

Imaging techniques, while very helpful in suggesting the presence of specific disease, cannot diagnose this (or any other neoplastic disease) with certainty. Definitive diagnosis is almost always achieved by biopsy, followed by microscopic, histologic and immunologic examination of the tissues obtained.[ citation needed ]

Significance

Recognition of this type of lymphoma presentation is important, in that it may predict the future course and potential complications of this disease, thereby alerting clinicians to undertake surveillance and appropriate interventions.[ citation needed ]

Related Research Articles

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Radiology is the medical discipline that uses medical imaging to diagnose and treat diseases within the bodies of animals and humans.

Lower gastrointestinal series Radiographs used to examine abnormalities of the colon

A lower gastrointestinal series is a medical procedure used to examine and diagnose problems with the human colon of the large intestine. Radiographs are taken while barium sulfate, a radiocontrast agent, fills the colon via an enema through the rectum.

Gastrointestinal stromal tumor Human disease (cancer)

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%), PDGFRA gene (10%), or BRAF kinase (rare). 95% of GISTs stain positively for KIT (CD117). Most (66%) occur in the stomach and gastric GISTs have a lower malignant potential than tumors found elsewhere in the GI tract.

Upper gastrointestinal series Radiographs used to examine abnormalities of the digestive system excluding the colon

An upper gastrointestinal series, also called a barium swallow, barium study, or barium meal, is a series of radiographs used to examine the gastrointestinal tract for abnormalities. A contrast medium, usually a radiocontrast agent such as barium sulfate mixed with water, is ingested or instilled into the gastrointestinal tract, and X-rays are used to create radiographs of the regions of interest. The barium enhances the visibility of the relevant parts of the gastrointestinal tract by coating the inside wall of the tract and appearing white on the film. This in combination with other plain radiographs allows for the imaging of parts of the upper gastrointestinal tract such as the pharynx, larynx, esophagus, stomach, and small intestine such that the inside wall lining, size, shape, contour, and patency are visible to the examiner. With fluoroscopy, it is also possible to visualize the functional movement of examined organs such as swallowing, peristalsis, or sphincter closure. Depending on the organs to be examined, barium radiographs can be classified into "barium swallow", "barium meal", "barium follow-through", and "enteroclysis". To further enhance the quality of images, air or gas is sometimes introduced into the gastrointestinal tract in addition to barium, and this procedure is called double-contrast imaging. In this case the gas is referred to as the negative contrast medium. Traditionally the images produced with barium contrast are made with plain-film radiography, but computed tomography is also used in combination with barium contrast, in which case the procedure is called "CT enterography".

Mesentery Contiguous fold of tissues that supports the intestines

The mesentery is an organ that attaches the intestines to the posterior abdominal wall in humans and is formed by the double fold of peritoneum. It helps in storing fat and allowing blood vessels, lymphatics, and nerves to supply the intestines, among other functions.

Diverticulitis Digestive disease caused by an inflammation of a herniating pouch (diverticulum)

Diverticulitis, specifically colonic diverticulitis, is a gastrointestinal disease characterized by inflammation of abnormal pouches—diverticula—which can develop in the wall of the large intestine. Symptoms typically include lower abdominal pain of sudden onset, but the onset may also occur over a few days. There may also be nausea; and diarrhea or constipation. Fever or blood in the stool suggests a complication. Repeated attacks may occur.

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Volvulus Twisting of part of the intestine, causing a bowel obstruction

A volvulus is when a loop of intestine twists around itself and the mesentery that supports it, resulting in a bowel obstruction. Symptoms include abdominal pain, abdominal bloating, vomiting, constipation, and bloody stool. Onset of symptoms may be rapid or more gradual. The mesentery may become so tightly twisted that blood flow to part of the intestine is cut off, resulting in ischemic bowel. In this situation there may be fever or significant pain when the abdomen is touched.

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Ischemic colitis Medical condition

Ischemic colitis is a medical condition in which inflammation and injury of the large intestine result from inadequate blood supply. Although uncommon in the general population, ischemic colitis occurs with greater frequency in the elderly, and is the most common form of bowel ischemia. Causes of the reduced blood flow can include changes in the systemic circulation or local factors such as constriction of blood vessels or a blood clot. In most cases, no specific cause can be identified.

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Omental cake Medical condition

Omental cake is a radiologic sign indicative of an abnormally thickened greater omentum. It refers to infiltration of the normal omental structure by other types of soft-tissue or chronic inflammation resulting in a thickened, or cake-like appearance.

Intestinal ischemia Restriction of blood flow to the small intestine resulting in injury

Intestinal ischemia is a medical condition in which injury to the large or small intestine occurs due to not enough blood supply. It can come on suddenly, known as acute intestinal ischemia, or gradually, known as chronic intestinal ischemia. The acute form of the disease often presents with sudden severe abdominal pain and is associated with a high risk of death. The chronic form typically presents more gradually with abdominal pain after eating, unintentional weight loss, vomiting, and fear of eating.

Abdominal x-ray AXR or KUB

An abdominal x-ray is an x-ray of the abdomen. It is sometimes abbreviated to AXR, or KUB.

Lung nodule Medical condition

A lung nodule or pulmonary nodule is a relatively small focal density in the lung. A solitary pulmonary nodule (SPN) or coin lesion, is a mass in the lung smaller than three centimeters in diameter. A pulmonary micronodule has a diameter of less than three millimetres. There may also be multiple nodules.

Idiopathic sclerosing mesenteritis Medical condition

Idiopathic sclerosing mesenteritis (ISM) is a rare disease of the small intestine, characterized by chronic inflammation and eventual fibrosis of the mesentery. It has also been called mesenteric lipodystrophy, or retractile mesenteritis.

Computed tomography of the abdomen and pelvis

Computed tomography of the abdomen and pelvis is an application of computed tomography (CT) and is a sensitive method for diagnosis of abdominal diseases. It is used frequently to determine stage of cancer and to follow progress. It is also a useful test to investigate acute abdominal pain. Renal stones, appendicitis, pancreatitis, diverticulitis, abdominal aortic aneurysm, and bowel obstruction are conditions that are readily diagnosed and assessed with CT. CT is also the first line for detecting solid organ injury after trauma.

Computed Tomography Enterography is a medical imaging technique which uses computed tomography scanner and contrast media to examine the small bowel. It was first introduced by Raptopoulos et al. in 1997. CT Enterography can be used to assess a variety of problems involving the small bowel, however it is mainly used to diagnosis and assess severity of Crohn's disease.

References

  1. Marshak, Richard (1961). "Roentgen findings in lesions of the small bowel". Journal Digestive Diseases and Sciences. 6 (11): 1084–1114. doi:10.1007/BF02231137. PMID   14470233. S2CID   30610401.
  2. Marshak; et al. (1980). Radiology of the Colon . W. B. Saunders Company. ISBN   978-0-7216-6129-2.
  3. Berry; Suri, Sudha (2008). Diagnostic Radiology: Gastrointestinal and Hepatobiliary Imaging. Jaypee Brothers Medical Publishers (P) Ltd. pp. 109–120. ISBN   978-81-8061-228-2.
  4. Wyatt, Susan H.; Fishman, Elliot K.; Jones, Bronwyn (1993). "Primary lymphoma of the colon and rectum: CT and barium enema correlation". Journal Abdominal Imaging. 18 (4): 376–380. doi:10.1007/BF00201787. PMID   8220042. S2CID   4544179.
  5. Ghai, Sangeet; Pattison, John (2007). "Primary Gastrointestinal Lymphoma: Spectrum of Imaging Findings with Pathologic Correlation". RadioGraphics. 27 (5): 1371–1388. doi: 10.1148/rg.275065151 . PMID   17848697.
  6. Gollub, M. (2008). "Imaging of Gastrointestinal Lymphoma". Radiologic Clinics of North America. 46 (2): 287–312. doi:10.1016/j.rcl.2008.03.002. PMID   18619382.