U.S. Route 441 (US 441) is a 939-mile-long (1,511 km) auxiliary route of U.S. Route 41. It extends from US 41 in Miami, Florida to US 25W in Rocky Top, Tennessee. Between its termini, US 441 travels through the states of Florida, Georgia, North Carolina, and Tennessee. The highway acts as a connector between several major urban areas, including Miami, Orlando, Ocala, Gainesville, Athens, and Knoxville. It also crosses the Great Smoky Mountains National Park, where it meets the southwestern end of the Blue Ridge Parkway, and where no trucks or other commercial traffic are allowed.
State Road 20 is a 358.154-mile-long (576.393 km) east-to-west route across northern Florida and the Florida Panhandle in the United States.
State Road 25 is a state highway in the U.S. state of Florida. It is mainly signed as U.S. Highways:
State Road 24 is an east–west state highway that runs between Cedar Key on the Gulf of Mexico and Waldo, Florida, at US 301. State Road 24 runs along a former branch of the Seaboard Air Line Railroad. This branch was originally owned by the Florida Railway and Navigation Company, and used to lead to ferries to both Pensacola, Florida and New Orleans, Louisiana. It also passes through Rosewood, site of the infamous 1923 massacre.
State Road 26 is a 62.172-mile-long (100.056 km) east–west route across North Central Florida.
State Route 32 (SR 32) is a 188.8-mile-long (303.8 km) state highway that travels west-to-east through portions of Terrell, Lee, Worth, Turner, Irwin, Coffee, Bacon, Pierce, Brantley, and Glynn counties in the southern part of the U.S. state of Georgia. The highway connects Dawson with Sterling, via Leesburg, Ashburn, Fitzgerald, Douglas, and Alma.
U.S. Highway 27 (US 27) in Florida is a north–south United States Numbered Highway. It runs 496.352 miles (798.801 km) from the Miami metropolitan area northwest to the Tallahassee metropolitan area. Throughout the state, US 27 has been designated the Claude Pepper Memorial Highway by the Florida Legislature. It was named after long-time Florida statesperson Claude Pepper, who served in both the U.S. Senate and House of Representatives. The stretch running from Miami to South Bay was originally designated the Thomas E. Will Memorial Highway by the Florida Legislature in 1937 when that portion was known as State Road 26 (SR 26). Thomas E. Will, the founder of Okeelanta, had worked for almost 20 years to get the state to build a road from Miami to the area south of Lake Okeechobee. For most of its length in the state, US 27 is a divided highway.
U.S. Highway 41 (US 41) in the state of Florida is a north–south United States Highway. It runs 479 miles (771 km) from Miami in South Florida northwest to the Georgia state line north of the Lake City area. Within the state, US 41 is paralleled by Interstate 75 (I-75) all the way from Miami to Georgia, and I-75 has largely supplanted US 41 as a major highway.
U.S. Route 98 is a major east-west thoroughfare through the U.S. state of Florida. Spanning 670.959 miles (1,079.804 km), it connects Pensacola and the Alabama/Florida state line to the west with Palm Beach and the Atlantic coast in the east. It is the longest US road in Florida, as well as the longest US road in any state east of the Mississippi River.
U.S. Route 129 (US 129) in Florida is a north–south United States Highway. It runs 88 miles (142 km) from Chiefland north to the Georgia State Line in Levy, Gilchrist, Suwannee, and Hamilton Counties.
U.S. Route 301 in Florida runs from the Sarasota-Bradenton-Venice, Florida Metropolitan Statistical Area northeast to the Greater Jacksonville Metropolitan Area. The road is a spur of U.S. Route 1, which it intersects in Callahan.
U.S. Route 441 (US 441) in Florida is a north–south United States Highway. It runs 433 miles (697 km) from Miami in South Florida northwest to the Georgia state line, with the overall route continuing to Tennessee in the Rocky Top area.
State Road 18 is a short state road in the U.S. state of Florida. It begins in Worthington Springs in southern Union County and travels eastward for 6.60 miles (10.62 km) into Bradford County until it becomes County Road 18 at Brooker. It also has county road extensions, one of which is between Fort White and Worthington Springs, and the other between Brooker and SR 100 north of Theressa.
State Road 331 is a short state highway running south and east of Gainesville, although it once stretched as far south as Williston. It also serves as a truck route for State Roads 24, 26, and 121 and US 441. Despite skirting the Gainesville City Limits, SR 331 runs north and south as a four-lane divided rural highway.
U.S. Highway 23 (US 23) in the U.S. state of Georgia is a north–south United States Numbered Highway that travels from the St. Marys River south-southeast of Folkston to the North Carolina state line, in the northern part of Dillard. At nearly 392 miles (631 km) in length, it is the longest U.S. Highway in Georgia.
State Road 329 (SR 329) was a short state highway traveling south and north through Gainesville, Florida. It comprised Main Street through Gainesville. The full length of the road extended from SR 331 to County Road 232 (CR 232). In the 1970s, the northern portion of the road, most of North Main Street, became County Road 329 (CR 329) while South Main Street was relinquished by the Florida Department of Transportation (FDOT) to the city. A small portion of the former state road in Gainesville is still maintained by the state as a portion of SR 20.
U.S. Route 441 (US 441) in the U.S. state of Georgia is a 354.2-mile-long (570.0 km) north–south United States Highway through the east-central portion of the state. It travels from the Florida state line near the Fargo city area to the North Carolina state line, in the northern part of Dillard. It is a spur route of US 41, although it has no intersections with its "parent" route within the state. It does have an intersection with another spur route of US 41 however, specifically US 341 in McRae–Helena.
State Road 235 is a south–north state highway in Alachua County, Florida. It runs from U.S. Route 441 in Alachua to Brooker, and has county-maintained segments in Alachua and Bradford Counties, which were once part of SR 235.
A total of at least twelve special routes of U.S. Route 441 have existed, and at least three have been deleted. These special routes include alternate routes, business loops, truck routes, and bypass routes which connect to U.S. Route 441 in the US states of Florida, Georgia, North Carolina, and Tennessee.
Several special routes of U.S. Route 129 exist, most of which are in the state of Georgia.
US 19 / US 98 at Lebanon Station 
US 27 / US 41 in Williston 
I-75 in Gainesville 
SR 16 in Raiford 
I-10 in Macclenny 
SR 23 / SR 121 near Stokesville, GA 
