GUCY1A2

GUCY1A2
Identifiers
Aliases	GUCY1A2 , GC-SA2, GUC1A2, guanylate cyclase 1, soluble, alpha 2, guanylate cyclase 1 soluble subunit alpha 2
External IDs	OMIM: 601244 MGI: 2660877 HomoloGene: 47953 GeneCards: GUCY1A2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	107,018,476 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	3,894,736 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; visceral pleura; ; saphenous vein; ; postcentral gyrus; ; lower lobe of lung; ; external globus pallidus; ; vena cava; ; endothelial cell; ; seminal vesicula; ; entorhinal cortex;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; spermatid; ; yolk sac; ; neural tube; ; esophagus; ; ganglionic eminence; ; mirror; ; spermatocyte; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP binding ; heme binding ; nucleotide binding ; phosphorus-oxygen lyase activity ; lyase activity ; protein binding ; guanylate cyclase activity ; adenylate cyclase activity ;
Cellular component	plasma membrane ; guanylate cyclase complex, soluble ; cytoplasm ;
Biological process	signal transduction ; intracellular signal transduction ; cyclic nucleotide biosynthetic process ; cGMP biosynthetic process ; positive regulation of nitric oxide mediated signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	2977
	234889
	ENSG00000152402
	ENSMUSG00000041624
	P33402
	n/a
	NM_001256424 ; NM_000855
	NM_001033322
	NP_000846 ; NP_001243353
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 09, 2023

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.^[5]^[6]

Related Research Articles

Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.

<span class="mw-page-title-main">Soluble guanylyl cyclase</span>

Soluble guanylyl cyclase (sGC) is the only known receptor for nitric oxide, NO. It is soluble, i.e. completely intracellular. Most notably, this enzyme is involved in vasodilation. In humans, it is encoded by the genes GUCY1A2, GUCY1A3, GUCY1B2 and GUCY1B3.

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein that in humans is encoded by the DLG3 gene. DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.

Natriuretic peptide receptor C/guanylate cyclase C , also known as NPR3, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR3 gene.

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha is an enzyme that in humans is encoded by the FNTA gene.

Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the MEP1A gene. The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice.

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.

Guanylyl cyclase-activating protein 1 is an enzyme that in humans is encoded by the GUCA1A gene.

Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene.

Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.

Prolyl 4-hydroxylase subunit alpha-1 is an enzyme that in humans is encoded by the P4HA1 gene.

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE6A gene.

<span class="mw-page-title-main">GUCY1A3</span> Protein-coding gene in the species Homo sapiens

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.

Retinal guanylyl cyclase 2 also known as guanylate cyclase F (GUCY2F) is a protein that in humans is encoded by the GUCY2F gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152402 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041624 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett. 292 (1–2): 217–22. doi: 10.1016/0014-5793(91)80871-Y . PMID 1683630. S2CID 84974514.
↑ "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

Baba H, Suzuki T, Arai H, Emson PC (2004). "Expression of nNOS and soluble guanylate cyclase in schizophrenic brain". NeuroReport. 15 (4): 677–80. doi:10.1097/00001756-200403220-00020. PMID 15094474. S2CID 45536193.
Bellamy TC, Wood J, Garthwaite J (2002). "On the activation of soluble guanylyl cyclase by nitric oxide". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 507–10. Bibcode:2002PNAS...99..507B. doi: 10.1073/pnas.012368499 . PMC 117590 . PMID 11752394.
Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi: 10.1074/jbc.M105587200 . PMID 11572861.
Bamberger AM, Koglin M, Kempfert J, et al. (2001). "Expression and tissue localization of soluble guanylyl cyclase in the human placenta using novel antibodies directed against the alpha(2) subunit". J. Clin. Endocrinol. Metab. 86 (2): 909–12. doi: 10.1210/jcem.86.2.7409 . PMID 11158065.
Budworth J, Meillerais S, Charles I, Powell K (1999). "Tissue distribution of the human soluble guanylate cyclases". Biochem. Biophys. Res. Commun. 263 (3): 696–701. doi:10.1006/bbrc.1999.1444. PMID 10512742.
Yu F, Warburton D, Wellington S, Danziger RS (1997). "Assignment of GUCIA2, the gene coding for the alpha 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11". Genomics. 33 (2): 334–6. doi: 10.1006/geno.1996.0208 . PMID 8660992.
Behrends S, Harteneck C, Schultz G, Koesling D (1995). "A variant of the alpha 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein". J. Biol. Chem. 270 (36): 21109–13. doi: 10.1074/jbc.270.36.21109 . PMID 7673142.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000152402 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041624 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1683630-5] Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G (Jan 1992). "Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme". FEBS Lett. 292 (1–2): 217–22. doi: 10.1016/0014-5793(91)80871-Y . PMID 1683630. S2CID 84974514.

[entrez-6] "Entrez Gene: GUCY1A2 guanylate cyclase 1, soluble, alpha 2".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

GUCY1A2

Related Research Articles

References

Further reading