GUCY1A3

GUCY1A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UVJ, 4NI2
Identifiers
Aliases	GUCY1A1 , MYMY6, GC-SA3, GUCY1A3, GUCSA3, guanylate cyclase 1 soluble subunit alpha, guanylate cyclase 1 soluble subunit alpha 1, guanylate cyclase 1, soluble, alpha 3, GUC1A3, GUCA3
External IDs	OMIM: 139396 MGI: 1926562 HomoloGene: 37360 GeneCards: GUCY1A1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	155,732,349 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	82,053,096 bp
RNA expression pattern
	Top expressed in
	urethra; ; vena cava; ; saphenous vein; ; visceral pleura; ; myocardium; ; right ventricle; ; superficial temporal artery; ; lower lobe of lung; ; lactiferous duct; ; middle temporal gyrus;
	Top expressed in
	olfactory tubercle; ; left lung lobe; ; habenula; ; ascending aorta; ; aortic valve; ; nucleus accumbens; ; atrium; ; atrioventricular valve; ; right lung lobe; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; guanylate cyclase activity ; GTP binding ; protein binding ; heme binding ; lyase activity ; phosphorus-oxygen lyase activity ; signaling receptor activity ; adenylate cyclase activity ;
Cellular component	cytoplasm ; plasma membrane ; guanylate cyclase complex, soluble ; glutamatergic synapse ; GABA-ergic synapse ;
Biological process	intracellular signal transduction ; cyclic nucleotide biosynthetic process ; blood circulation ; regulation of blood pressure ; cGMP biosynthetic process ; relaxation of vascular associated smooth muscle ; nitric oxide mediated signal transduction ; positive regulation of nitric oxide mediated signal transduction ; retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission ;
	Sources:Amigo / QuickGO
Orthologs
	2982
	60596
	ENSG00000164116
	ENSMUSG00000033910
	Q02108 ; Q6PJR4
	Q9ERL9
NM_000856 ; NM_001130682 ; NM_001130683 ; NM_001130684 ; NM_001130685 ;
	NM_001130686 ; NM_001130687 ; NM_001256449
	NM_021896 ; NM_001356987 ; NM_001356988
NP_000847 ; NP_001124154 ; NP_001124155 ; NP_001124156 ; NP_001124157 ;
	NP_001124159 ; NP_001243378 ; NP_001366595 ; NP_001366596 ; NP_001366597 ; NP_001366598 ; NP_001366599 ; NP_001366600 ; NP_001366601 ; NP_001366602 ; NP_001366603 ; NP_001366604 ; NP_001366605 Contents Function ; References ; Further reading ;
	NP_068696 ; NP_001343916 ; NP_001343917
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 09, 2023

Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.^[5]^[6]

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.^[6] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).

Related Research Articles

<span class="mw-page-title-main">Cyclic guanosine monophosphate</span> Chemical compound

Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). cGMP acts as a second messenger much like cyclic AMP. Its most likely mechanism of action is activation of intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the external cell surface. Through protein kinases activation, cGMP can relax smooth muscle. cGMP concentration in urine can be measured for kidney function and diabetes detection.

<span class="mw-page-title-main">Guanylate cyclase</span> Lyase enzyme that synthesizes cGMP from GTP

Guanylate cyclase is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate:

Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.

<span class="mw-page-title-main">Soluble guanylyl cyclase</span>

Soluble guanylyl cyclase (sGC) is the only known receptor for nitric oxide, NO. It is soluble, i.e. completely intracellular. Most notably, this enzyme is involved in vasodilation. In humans, it is encoded by the genes GUCY1A2, GUCY1A3, GUCY1B2 and GUCY1B3.

Retinal guanylyl cyclase 1 also known as guanylate cyclase 2D, retinal is an enzyme that in humans is encoded by the GUCY2D gene.

Natriuretic peptide receptor C/guanylate cyclase C , also known as NPR3, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR3 gene.

Glucosidase 2 subunit beta is an enzyme that in humans is encoded by the PRKCSH gene.

Guanylyl cyclase-activating protein 1 is an enzyme that in humans is encoded by the GUCA1A gene.

Guanine nucleotide-binding protein G(t) subunit alpha-2 is a protein that in humans is encoded by the GNAT2 gene.

Guanine nucleotide-binding protein G(t) subunit alpha-1 is a protein that in humans is encoded by the GNAT1 gene.

Adenylyl cyclase type 7 is an enzyme that in humans is encoded by the ADCY7 gene.

Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein. Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium. In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio. The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.

Gamma-aminobutyric acid receptor subunit alpha-6 is a protein that in humans is encoded by the GABRA6 gene.

The human ATP5F1C gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.

Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE6A gene.

The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.

Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene. Its main product is the heterotrimeric G-protein alpha subunit G_olf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.

Guanylyl cyclase-activating protein 2 is an enzyme that in humans is encoded by the GUCA1B gene. Alternative names:

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164116 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033910 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.
1 2 "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".

Giuili G, Roechel N, Scholl U, et al. (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486. S2CID 24237232.
Papapetropoulos A, Cziraki A, Rubin JW, et al. (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. doi: 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S . PMID 8613461. S2CID 25406282.
Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. doi:10.1042/bj3350051. PMC 1219751 . PMID 9742212.
Zhou Y, Zheng JB, Gu X, et al. (2000). "A novel Pax-6 binding site in rodent B1 repetitive elements: coevolution between developmental regulation and repeated elements?". Gene. 245 (2): 319–28. doi:10.1016/S0378-1119(00)00019-6. PMID 10717483.
Behrends S, Vehse K, Scholz H, et al. (2000). "Assignment of GUCY1A3, a candidate gene for hypertension, to human chromosome bands 4q31.1→q31.2 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 204–5. doi:10.1159/000015548. PMID 10828587. S2CID 5178613.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Saino M, Maruyama T, Sekiya T, et al. (2005). "Inhibition of angiogenesis in human glioma cell lines by antisense RNA from the soluble guanylate cyclase genes, GUCY1A3 and GUCY1B3". Oncol. Rep. 12 (1): 47–52. doi:10.3892/or.12.1.47. PMID 15201957.
Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164116 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033910 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1352257-5] Giuili G, Scholl U, Bulle F, Guellaen G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.

[entrez-6] 1 2 "Entrez Gene: GUCY1A3 guanylate cyclase 1, soluble, alpha 3".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

GUCY1A3

Contents

Function

Related Research Articles

References

Further reading