MIR222

Last updated
MIR222
Identifiers
Aliases MIR222 , MIRN222, miRNA222, mir-222, microRNA 222
External IDs OMIM: 300569 GeneCards: MIR222
Gene location (Human)
Ideogram human chromosome X.svg
Chr. X chromosome (human) [1]
Human chromosome X ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band Xp11.3Start45,747,015 bp [1]
End45,747,124 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

407007

n/a

Ensembl

ENSG00000207725

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC) Chr X: 45.75 – 45.75 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

MicroRNA 222 is a MicroRNA that in humans is encoded by the MIR222 gene, and is a known extracellular RNA (exRNA). [3]

Function

microRNA s (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Related Research Articles

MicroRNA 4640 is a protein in humans that is encoded by the MIR4640 gene.

MicroRNA 1269a is a protein that in humans is encoded by the MIR1269A gene.

MIR133A1

MicroRNA 133a-1 is a MicroRNA that in humans is encoded by the MIR133A1 gene, and is a known extracellular RNA (exRNA).

MicroRNA 660 is a miRNA that in humans is encoded by the MIR660 gene.

MicroRNA 361 is a micro RNA that in humans is encoded by the MIR361 gene.

MicroRNA 5008 is a protein that in humans is encoded by the MIR5008 gene.

MicroRNA 4521 is a protein that in humans is encoded by the MIR4521 gene.

MicroRNA let-7a-2 is a protein that in humans is encoded by the MIRLET7A2 gene.

MicroRNA 5680 is a protein that in humans is encoded by the MIR5680 gene.

MicroRNA 3173 is a protein that in humans is encoded by the MIR3173 gene.

MicroRNA 486-1 is a functional RNA that in humans is encoded by the MIR486-1 gene.

MicroRNA 7-2 is a non-protein-coding gene product that in humans is encoded by the MIR7-2 gene.

MicroRNA 4761 is a microRNA that in humans is encoded by the MIR4761 gene.

MicroRNA 320b-2 is a protein that in humans is encoded by the MIR320B2 gene.

MicroRNA 6079 is a protein that in humans is encoded by the MIR6079 gene.

MicroRNA 6850 is a protein that in humans is encoded by the MIR6850 gene.

MicroRNA 548v is a protein that in humans is encoded by the MIR548V gene.

MicroRNA 4727 is a protein that in humans is encoded by the MIR4727 gene.

MicroRNA 1250 is a protein that in humans is encoded by the MIR1250 gene.

MicroRNA 1282 is a protein that in humans is encoded by the MIR1282 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000207725 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Entrez Gene: MicroRNA 222".


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.