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The oxygen cocktail is a foamy substance containing a beverage drink (juice, milk, etc.) enriched in gaseous oxygen. The drink is used as part of oxygen therapy by a number of Soviet medical institutions; their research suggest that the drink, by supplying oxygen, allegedly reduces chronic fatigue syndrome and hypoxia and activates metabolism. [1]
The oxygen cocktail was developed in the 1960s by the Russian academician N. N. Sirotinin. [2] While researching the respiratory function of the stomach and the possibility of filling the body with oxygen through the digestive tract, Soviet doctors put probes into the patients' stomachs, through which the body could be filled with up to 2 liters of oxygen. Although the condition of the patients improved considerably, this method had to be abandoned because of discomfort caused by the probes. In an alternative treatment, a foam-forming liquid was filled with oxygen and transferred to the patient's mouth via a tube. Later, researches suggested adding the oxygen foam into food or drink. Such oxygen-enriched drinks received the name “oxygen cocktail” and were produced in sanatoriums and clinics. Since the 1970s, the method of making such drinks has undergone almost no changes, but the foam-forming ingredients and the ways of filling the cocktails with oxygen have been improved. [3]
Juices (grape, cherry, raspberry, etc.), syrups, water, milk and fruit-drinks are often used as the base of the cocktail. Oily and sparkling liquids result in poor homogeneity of the foam. The base liquid might contain extracts of plants and herbs such as hawthorn, strawflower, motherwort and rose hip, which themselves are used in the clinical practices. An essential element of the oxygen cocktail is the foaming agent, such as gelatin egg white or liquorice. Initially, oxygen cocktails were made with egg white. However clinical trials proved that this ingredient resulted in allergenicity and unpleasant taste and could promote infectious diseases; thus it was replaced by liquorice, which is a foaming agent, tonic and sedative. [3] [4]
After entering the intestines, the oxygen from the cocktail allegedly absorbs into the blood, [3] where it stimulates metabolism, blood circulation, redox and the immune system. [1] The activated metabolism also stimulates the digesting of other cocktail's ingredients, thereby enhancing their medical action.
The use of oxygen cocktail for medical rehabilitation was allegedly studied at the gynecological department of medical rehabilitation of the "Research Center of Obstetrics, Gynecology and Perinatology". It was demonstrated that using the oxygen cocktails as a part of the complex therapy of adults, children and teenagers with inflammations of uterine appendages, optimized metabolism and activated antioxidants in the blood plasma, thereby improving the general condition of the patients. This result was confirmed in other Russian clinics. [5] [6]
In 2005 the Research Center of Children's Health (Russian Academy of Medical Sciences) studied the efficiency of the oxygen cocktails as a part of the complex therapy of children and teenagers with chronic diseases of the respiratory and digestive tracts. Patients took 200 mL of the oxygen cocktail per day. It was concluded that the oxygen cocktail activates metabolism, reduces fatigue and stimulates efficiency and the immune system without visible side effects. Improvement was observed for all patients with respiratory diseases and 85% of the children having digestive tract problems. [7] The efficiency of the oxygen cocktail in prevention and therapy of placental deficiency and fetal hypoxia was proved during the 2006 study at the obstetrics and gynecology department of the Peoples' Friendship University of Russia. [8]
As a result of these studies, it was suggested that the oxygen cocktail
Pubmed (as in 2022) gives nine papers on a search query "oxygen cocktail", all are in Russian (and published in Russian journals), four of them have English abstracts. Two of these studies weren't aimed to have control groups, [9] [10] the two others assessed oxygen cocktails in a combination of additional measures that included many other different techniques. [11] [12]
In Russia, oxygen cocktails are prescribed for expecting mothers, sportsmen, children and teenagers, people living in poor ecological conditions or experiencing hypoxia, cardiovascular system and digestive tract diseases, having problems with the immune system, insomnia, chronic fatigue syndrome and excessive body weight.
The contraindications of the oxygen cocktail are:
In Ulaanbaatar, Mongolia, people consume Russian branded oxygen cocktails to protect themselves from yearly winter smog, and the Head of a WHO's Department Maria Neira criticized that practice as scientifically unproven. [13]
Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. Although hypoxia is often a pathological condition, variations in arterial oxygen concentrations can be part of the normal physiology, for example, during strenuous physical exercise.
Meconium aspiration syndrome (MAS) also known as neonatal aspiration of meconium is a medical condition affecting newborn infants. It describes the spectrum of disorders and pathophysiology of newborns born in meconium-stained amniotic fluid (MSAF) and have meconium within their lungs. Therefore, MAS has a wide range of severity depending on what conditions and complications develop after parturition. Furthermore, the pathophysiology of MAS is multifactorial and extremely complex which is why it is the leading cause of morbidity and mortality in term infants.
Shortness of breath (SOB), also medically known as dyspnea or dyspnoea, is an uncomfortable feeling of not being able to breathe well enough. The American Thoracic Society defines it as "a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity", and recommends evaluating dyspnea by assessing the intensity of its distinct sensations, the degree of distress and discomfort involved, and its burden or impact on the patient's activities of daily living. Distinct sensations include effort/work to breathe, chest tightness or pain, and "air hunger". The tripod position is often assumed to be a sign.
Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism. Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue i.e. hypoxia and microvascular dysfunction. It also implies local hypoxia in a part of a body resulting from constriction. Ischemia causes not only insufficiency of oxygen, but also reduced availability of nutrients and inadequate removal of metabolic wastes. Ischemia can be partial or total blockage. The inadequate delivery of oxygenated blood to the organs must be resolved either by treating the cause of the inadequate delivery or reducing the oxygen demand of the system that needs it. For example, patients with myocardial ischemia have a decreased blood flow to the heart and are prescribed with medications that reduce chronotrophy and ionotrophy to meet the new level of blood delivery supplied by the stenosed vasculature so that it is adequate.
Oxygen therapy, also referred to as supplemental oxygen, is the use of oxygen as medical treatment. Supplemental oxygen can also refer to the use of oxygen enriched air at altitude. Acute indications for therapy include hypoxemia, carbon monoxide toxicity and cluster headache. It may also be prophylactically given to maintain blood oxygen levels during the induction of anesthesia. Oxygen therapy is often useful in chronic hypoxemia caused by conditions such as severe COPD or cystic fibrosis. Oxygen can be delivered via nasal cannula, face mask, or endotracheal intubation at normal atmospheric pressure, or in a hyperbaric chamber. It can also be given through bypassing the airway, such as in ECMO therapy.
Polycythemia is a laboratory finding in which the hematocrit and/or hemoglobin concentration are increased in the blood. Polycythemia is sometimes called erythrocytosis, and there is significant overlap in the two findings, but the terms are not the same: polycythemia describes any increase in hematocrit and/or hemoglobin, while erythrocytosis describes an increase specifically in the number of red blood cells in the blood.
Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds used to kill certain ingested pathogens. This leads to the formation of granulomas in many organs. CGD affects about 1 in 200,000 people in the United States, with about 20 new cases diagnosed each year.
Generalized hypoxia is a medical condition in which the tissues of the body are deprived of the necessary levels of oxygen due to an insufficient supply of oxygen, which may be due to the composition or pressure of the breathing gas, decreased lung ventilation, or respiratory disease, any of which may cause a lower than normal oxygen content in the arterial blood, and consequently a reduced supply of oxygen to all tissues perfused by the arterial blood. This usage is in contradistinction to localized hypoxia, in which only an associated group of tissues, usually with a common blood supply, are affected, usually due to an insufficient or reduced blood supply to those tissues. Generalized hypoxia is also used as a synonym for hypoxic hypoxia This is not to be confused with hypoxemia, which refers to low levels of oxygen in the blood, although the two conditions often occur simultaneously, since a decrease in blood oxygen typically corresponds to a decrease in oxygen in the surrounding tissue. However, hypoxia may be present without hypoxemia, and vice versa, as in the case of infarction. Several other classes of medical hypoxia exist.
Bacterial pneumonia is a type of pneumonia caused by bacterial infection.
Respiratory acidosis is a state in which decreased ventilation (hypoventilation) increases the concentration of carbon dioxide in the blood and decreases the blood's pH.
Exercise intolerance is a condition of inability or decreased ability to perform physical exercise at the normally expected level or duration for people of that age, size, sex, and muscle mass. It also includes experiences of unusually severe post-exercise pain, fatigue, nausea, vomiting or other negative effects. Exercise intolerance is not a disease or syndrome in and of itself, but can result from various disorders.
Pulmonary fibrosis is a condition in which the lungs become scarred over time. Symptoms include shortness of breath, a dry cough, feeling tired, weight loss, and nail clubbing. Complications may include pulmonary hypertension, respiratory failure, pneumothorax, and lung cancer.
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.
Pneumonitis describes general inflammation of lung tissue. Possible causative agents include radiation therapy of the chest, exposure to medications used during chemo-therapy, the inhalation of debris, aspiration, herbicides or fluorocarbons and some systemic diseases. If unresolved, continued inflammation can result in irreparable damage such as pulmonary fibrosis.
Hypoxemia is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood. Hypoxemia has many causes, and often causes hypoxia as the blood is not supplying enough oxygen to the tissues of the body.
Smoke inhalation is the breathing in of harmful fumes through the respiratory tract. This can cause smoke inhalation injury which is damage to the respiratory tract caused by chemical and/or heat exposure, as well as possible systemic toxicity after smoke inhalation. Smoke inhalation can occur from fires of various sources such as residential, vehicle, and wildfires. Morbidity and mortality rates in fire victims with burns are increased in those with smoke inhalation injury. Victims of smoke inhalation injury can present with cough, difficulty breathing, low oxygen saturation, smoke debris and/or burns on the face. Smoke inhalation injury can affect the upper respiratory tract, usually due to heat exposure, or the lower respiratory tract, usually due to exposure to toxic fumes. Initial treatment includes taking the victim away from the fire and smoke, giving 100% oxygen at a high flow through a face mask, and checking the victim for injuries to the body. Treatment for smoke inhalation injury is largely supportive, with varying degrees of consensus on benefits of specific treatments.
A hypoxicator is a medical device intended to provide a stimulus for the adaptation of an individual's cardiovascular system by means of breathing reduced oxygen hypoxic air and triggering mechanisms of compensation. The aim of intermittent hypoxic training or hypoxic therapy conducted with such a device is to obtain benefits in physical performance and wellbeing through improved oxygen metabolism.
In some individuals, the effect of oxygen on chronic obstructive pulmonary disease is to cause increased carbon dioxide retention,
In herbal medicine, an herbal tonic is used to help restore, tone and invigorate systems in the body or to promote general health and well-being. An herbal tonic is a solution or other preparation made from a specially selected assortment of plants known as herbs. They are steeped in water and drunk either hot or cool. Herbal tonics are believed to have healing properties ranging from relieving muscle and joint pain and extend as far as inhibiting some cancers.
Intermittent hypoxia (also known as episodic hypoxia) is an intervention in which a person or animal undergoes alternating periods of normoxia and hypoxia. Normoxia is defined as exposure to oxygen levels normally found in Earth's atmosphere (~21% O2) and hypoxia as any oxygen levels lower than those of normoxia. Normally, exposure to hypoxia is negatively associated to physiological changes to the body, such as altitude sickness. However, when used in moderation, intermittent hypoxia may be used clinically as a means to alleviate various pathological conditions.