SYT6

SYT6
Identifiers
Aliases	SYT6 , sytVI, synaptotagmin 6
External IDs	OMIM: 607718 MGI: 1859544 HomoloGene: 10301 GeneCards: SYT6
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.2 Start 114,089,291 bp [1] End 114,153,880 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 103,482,547 bp [2] End 103,552,885 bp [2]
RNA expression pattern Bgee Top expressed in neocortex caudate nucleus hypothalamus nucleus accumbens cerebral cortex pancreas prosencephalon More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding protein homodimerization activity clathrin binding calcium-dependent protein binding metal ion binding GO:0001948 protein binding identical protein binding calcium-dependent phospholipid binding syntaxin binding phosphatidylserine binding SNARE binding Cellular component cytoplasm integral component of membrane cytosol membrane perinuclear endoplasmic reticulum synapse synaptic vesicle membrane cell junction GO:0016023 cytoplasmic vesicle plasma membrane extrinsic component of membrane glutamatergic synapse integral component of synaptic membrane exocytic vesicle Biological process acrosomal vesicle exocytosis acrosome reaction regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter vesicle fusion presynaptic dense core vesicle exocytosis regulation of dopamine secretion synaptic vesicle exocytosis vesicle-mediated transport calcium-ion regulated exocytosis cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	148281	54524
Ensembl	ENSG00000134207	ENSMUSG00000027849
UniProt	Q5T7P8	Q9R0N8
RefSeq (mRNA)	NM_001253772 NM_001270805 NM_205848 NM_001366223 NM_001366224 NM_001366225 NM_001366226	NM_001276676 NM_001276677 NM_001276679 NM_001276680 NM_001276681 NM_018800
RefSeq (protein)	NP_001257734 NP_995320 NP_001240701 NP_001353152 NP_001353153 NP_001353154 NP_001353155	NP_001263605 NP_001263606 NP_001263608 NP_001263609 NP_001263610 NP_061270
Location (UCSC)	Chr 1: 114.09 – 114.15 Mb	Chr 3: 103.48 – 103.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene. ^{[5] [6]}

Function

Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000134207 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027849 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID   11543631.
6. "Entrez Gene: SYT6 synaptotagmin VI".

Further reading

• Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS (September 2005). "Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis". Developmental Biology. 285 (2): 422–35. doi: 10.1016/j.ydbio.2005.07.007 . PMID   16111671.
• Michaut M, De Blas G, Tomes CN, Yunes R, Fukuda M, Mayorga LS (July 2001). "Synaptotagmin VI participates in the acrosome reaction of human spermatozoa". Developmental Biology. 235 (2): 521–9. doi: 10.1006/dbio.2001.0316 . PMID   11437455.
• Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID   8901523.
• Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID   7791877. S2CID   4265549.