U.S. Route 58 is an east–west U.S. Highway that runs for 508 miles (818 km) from U.S. Route 25E just northwest of Harrogate, Tennessee, to U.S. Route 60 in Virginia Beach, Virginia. Until 1996, when the Cumberland Gap Tunnel opened, US 58 ran only inside the commonwealth of Virginia. It was then extended southwest along a short piece of former US 25E, which no longer enters Virginia, to end at the new alignment in Tennessee.
State Route 5 runs between the independent cities of Richmond and Williamsburg in the U.S. state of Virginia. Between Charles City County and James City County, it crosses the Chickahominy River via the Judith Stewart Dresser Bridge, a fixed-span bridge which replaced historic Barrett's Ferry and the former drawbridge.
State Route 169 is a primary state highway in the U.S. state of Virginia. The state highway runs 7.41 miles (11.93 km) from Interstate 64 (I-64) and U.S. Route 60 to US 258 within the independent city of Hampton. SR 169 is a C-shaped route that connects the Hampton neighborhoods of Phoebus, Buckroe Beach, and Fox Hill.
U.S. Route 421 (US 421) is a part of the U.S. Highway System that runs from Fort Fisher, North Carolina to Michigan City, Indiana. In Virginia, the U.S. Highway runs 69.23 miles (111.41 km) from the Tennessee state line between the twin cities of Bristol, Tennessee and Bristol, Virginia north and west to the Kentucky state line near St. Charles. Between its endpoints, US 421 has lengthy concurrencies with US 23 and US 58 during its course through Bristol, Weber City, Gate City, Duffield, and Pennington Gap in Southwest Virginia.
State Route 71 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from Gate City northeast to Lebanon, mostly through river valleys. Despite running more east–west than north–south, it is signed north–south; it parallels the similarly-oriented U.S. Route 11 and Interstate 81.
State Route 72 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from SR 71 in Gate City north to SR 65 at Fort Blackmore, northeast with SR 65 to Dungannon, and north via Coeburn to SR 83 near Clintwood.
State Route 75 is a primary state highway in the southwest part of the U.S. state of Virginia, running southwest from U.S. Route 11 and U.S. Route 58 Alternate in Abingdon to Tennessee's State Route 44.
State Route 67 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from State Route 80 near Honaker east to U.S. Route 460 at Raven, east concurrently with US 460 and U.S. Route 460 Business into downtown Richlands, and north to State Route 616 at Jewell Ridge on the Tazewell–Buchanan county line.
State Route 16 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from the North Carolina border at North Carolina Highway 16 north to the West Virginia border at West Virginia Route 16, passing through the towns of Troutdale, Marion, and Tazewell. Highway 16 is part of a three-state route 16 that connects the Charlotte region with northwestern West Virginia.
State Route 80 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from the Kentucky state line at Breaks Interstate Park east to U.S. Route 11 near Meadowview. Kentucky Route 80 and Missouri's Route 80 continue the number west to Matthews, Missouri.
In the U.S. state of Virginia, U.S. Route 220 (US 220) is a major north-south state highway that extends from the North Carolina state line through Roanoke to the West Virginia state line. South of Roanoke, US 220 is a four-lane highway within the proposed Interstate 73 (I-73) corridor. US 220 narrows to two lanes north of Roanoke, connecting to I-64 near Clifton Forge and then paralleling the Appalachian Mountains north-northeasterly in the direction of Cumberland, Maryland.
State Route 13 is a primary state highway in the U.S. state of Virginia. Known as Old Buckingham Road, the state highway runs 24.08 miles (38.75 km) from U.S. Route 60 and SR 45 in Cumberland east to US 60 in Plain View. SR 13 parallels US 60 to the south through eastern Cumberland County and western Powhatan County and passes through the latter county's seat of Powhatan. The state highway is the only state-numbered highway in Virginia that shares a number with a U.S. Highway but does not form a state-numbered extension of that U.S. Highway. SR 13's number comes from being a segment of the original cross-state SR 13 in 1918; that highway included portions of modern US 60. In 1933, US 60 was shifted to its present corridor between Buena Vista and Richmond, replacing SR 13. Two years later, SR 13 was assigned to Old Buckingham Road when US 60 was moved to its present alignment from Cumberland to east of Powhatan.
Virginia Byway 
SR 70 near Kyles Ford, TN 
US 58 in Jonesville 
