The 1921 College Baseball All-Southern Team consists of baseball players selected at their respective positions after the 1921 NCAA baseball season. Vanderbilt won the SIAA.
| Position | Name | School | Notes |
|---|---|---|---|
| Pitcher | Jack Frost | Georgia | |
| Cliff Pantone | CW | ||
| Tige Stone | Mercer | CW | |
| Chief Turk | Oglethorpe | CW | |
| Sunshine Thompson | Georgia Tech | CW | |
| Ollinger | Auburn | ||
| George Johnson | CW | ||
| Jim Joe Edwards | Mississippi College | CW | |
| Catcher | Charlie Gibson | Auburn | |
| Byrd Hope | Oglethorpe | CW | |
| Luke Sewell | Alabama | CW | |
| First baseman | Lassiter | Auburn | |
| Chief Cody | Georgia | CW | |
| Bevo Webb | Georgia Tech | ||
| Second baseman | Sam Barnes | Auburn | CW |
| Third baseman | Eddie Morgan | Georgia Tech | CW |
| Shortstop | Dot Fulghum | Auburn | CW |
| Doc Kuhn | Vanderbilt | ||
| Outfielder | Esau Settle | Georgia Tech | CW |
| Red Barron | |||
| Sox Ingram | |||
| Roy Carlyle | Oglethorpe | ||
| Ed Sherling | Auburn | ||
| Manning Brown | Vanderbilt | ||
| Boozer McWhorter | Georgia | ||
| Country Mangum | CW | ||
| Tot McCullough | Vanderbilt | CW |
CW = Cliff Wheatley's selection. [2]