The 2007 tuberculosis scare occurred when a personal-injury lawyer from Atlanta, Andrew "Drew" Speaker, while infected with multidrug-resistant tuberculosis (MDR-TB), flew on several international flights bound for France, Greece, Italy, Czech Republic and Canada, before returning to the United States. [1] [2] The Centers for Disease Control and Prevention believed at the time that Speaker was suffering from extensively drug-resistant tuberculosis (XDR-TB), but failed to inform Speaker of this worsened sickness before his travels abroad. The incident sparked a debate in Congress on the failure of federal customs agents to stop him. [2] Upon Speaker's return to the United States, the CDC placed him under involuntary isolation (similar to quarantine) using a provision of the Public Health Service Act. [3] With this action, Speaker became the first individual subjected to a CDC isolation order since 1963. [4]
In January 2007, Speaker suffered a fall and went to the doctor, concerned that he had bruised a rib. Doctors X-rayed his chest and found an abnormality that required further testing. [5]
On March 28, 2007, his doctors and the health department believed the tuberculosis (TB) strain that Speaker had was a resistant one and communicated this to the CDC. On May 1 the apparent MDR TB infection was discussed with the CDC lab by his doctors and they discussed discontinuing the treatment he was on at that time. On May 9 the suspicion of MDR TB was confirmed. A meeting was held with Fulton County Health Officials, his doctors, his fiancée, as well as his father and father-in-law on May 10, 2007. During this meeting, Speaker was informed that while he was not considered contagious or a threat to other, he would need to travel to Denver for treatment. [5] After weeks of arranging this, he was still advised—or in some accounts—strongly recommended, not to travel. [5]
On May 12, 2007, Speaker flew from the U.S. to Paris. On May 14, he flew on to Athens and, two days later, flew to the Aegean holiday island of Santorini for his wedding. Speaker then flew to Rome for his honeymoon.
Doctors say that only after Speaker left the United States did they realize he likely had XDR-TB. Speaker says that he was informed of MDR TB before leaving the country, and that while officials preferred him not to fly, they said that he was not a threat and was not required to wear a mask. [6] Once Speaker was in Europe, however, test results showed his strain of tuberculosis was even rarer than originally thought, leading public health officials to try to persuade Speaker to turn himself in to Italian health authorities. [7] [8] The CDC informed him that there were no options for the CDC to get him home, and that he would have to arrange private transportation. Speaker instead flew by commercial jet to Prague and then on to Montréal. [9] Both Speaker and his new wife claimed that, had they been offered transport, they would have accepted it and would have waited in Rome. [10] Speaker has also said that the CDC told him they were going to send officials to put him in Italian quarantine for up to two years, and that he was not told special transportation was arranged. [10]
Once in Montréal, Speaker rented a car and drove across the Canada–United States border. A Customs and Border Protection Officer, after passing Speaker's passport through the Treasury Enforcement Communications System (TECS), [2] failed to detain him at the frontier despite a warning to hold the traveler, wear a protective mask when dealing with him, and call health authorities, stating that Speaker "did not look sick". [11]
According to the CDC, Speaker flew on the following flights: [12]
Airlines | Flight# | Aircraft | Date | Departing | Scheduled Departure | Calculated Scheduled Duration | Arriving | Number of Passengers | Patient Seat Row Number |
---|---|---|---|---|---|---|---|---|---|
Air France / Delta | 385 / 8517 | Boeing 747-400 | 2007-05-12 | Atlanta, Georgia | 8:45 PM Local | 8 Hr 27 Min | Paris, France | 433 | 30 |
Air France | 1232 | Airbus A320 | 2007-05-14 | Paris, France | 7:35 AM Local | 3 Hr 11 Min | Athens, Greece | not more than 172 | unknown |
Olympic Air | 560 | ATR 72-202 | 2007-05-16 | Athens, Greece | 7:25 PM Local | 0 Hr 40 Min | Thira Island, Greece | not more than 74 | unknown |
Olympic Air | 655 | ATR 72-202 | 2007-05-21 | Mykonos Island, Greece | 1:45 PM Local | 0 Hr 40 Min | Athens, Greece | not more than 74 | unknown |
Olympic Air | 239 | Boeing 737-400 | 2007-05-21 | Athens, Greece | 5:30 PM Local | 2 Hr 05 Min | Rome, Italy | not more than 168 | unknown |
Czech Airlines | 727 | Boeing 737-400 | 2007-05-24 | Rome, Italy | 8:50 AM Local | 1 Hr 55 Min | Prague, Czech Republic | not more than 168 | unknown |
Czech Airlines | 0104 | Airbus A310 | 2007-05-24 | Prague, Czech Republic | 12:25 PM Local | 8 Hr 25 Min | Montreal, Canada | 191 | 12 |
On May 31, 2007, Speaker was moved from Grady Memorial Hospital in Atlanta to the National Jewish Medical and Research Center in Denver, Colorado, for further treatment. [13]
It was reported that Speaker's father-in-law, Robert C. Cooksey, works for the Centers for Disease Control and Prevention and is a microbiologist who has conducted research on tuberculosis, according to his CDC biography posted on the agency's Web site. [14]
Wearing a medical mask, Speaker was interviewed by Diane Sawyer on the June 1 edition of the American talk show Good Morning America on ABC and apologized to all passengers, explaining that he had not intended to endanger them. [15]
On July 4, 2007, the National Jewish Medical and Research Center announced, and the CDC confirmed, that Speaker's earlier diagnosis was incorrect and that he instead had multidrug-resistant tuberculosis (MDR-TB), a more treatable form of tuberculosis. [16] On July 26, 2007, Speaker was discharged after undergoing surgery to remove infected lung tissue and receiving antibiotic treatment. A statement by his physicians said that he was no longer contagious, showed no detectable evidence of infection, and that he would continue antibiotic therapy for approximately two years. [17]
In 2007, seven Canadians and two Czechs sued Speaker in Montreal Superior Court; eight of the plaintiffs were on the same flight as Andrew Speaker and one was related to one of the passengers. [18]
In 2009, Speaker sued the CDC for invasion of privacy, claiming that the release of his personal and medical information caused significant harm to his reputation and marriage. [19] [20] The lawsuit was dismissed later in 2009 by a U.S. District Court judge, [21] revived in 2010 by the 11th U.S. Circuit Court of Appeals, and finally dismissed again in 2012 by a U.S. District Court judge. [22]
Speaker was in New York when the CDC served him with an isolation order but CDC director Julie Gerberding stated that the government was legally constrained prior to that order. The federal statute under section 361 of the Public Health Service Act grants the federal government the ability to isolate or quarantine individuals but only those coming into the country from a foreign nation or territory. [23] [24]
Georgia TB law may have required Speaker to be confined for two weeks and only allowed travel for medical appointments. [25] A court confinement order can isolate a patient only after the infected patient ignores medical advice. This method can be overridden by a declaration of public health emergency by the governor of Georgia.
Tuberculosis (TB), also known colloquially as the "white death", or historically as consumption, is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in which case it is known as latent tuberculosis. Around 10% of latent infections progress to active disease that, if left untreated, kill about half of those affected. Typical symptoms of active TB are chronic cough with blood-containing mucus, fever, night sweats, and weight loss. Infection of other organs can cause a wide range of symptoms.
Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB.
Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to at least one antimicrobial drug in three or more antimicrobial categories. Antimicrobial categories are classifications of antimicrobial agents based on their mode of action and specific to target organisms. The MDR types most threatening to public health are MDR bacteria that resist multiple antibiotics; other types include MDR viruses, parasites.
Latent tuberculosis (LTB), also called latent tuberculosis infection (LTBI) is when a person is infected with Mycobacterium tuberculosis, but does not have active tuberculosis (TB). Active tuberculosis can be contagious while latent tuberculosis is not, and it is therefore not possible to get TB from someone with latent tuberculosis. The main risk is that approximately 10% of these people will go on to develop active tuberculosis. This is particularly true, and there is added risk, in particular situations such as medication that suppresses the immune system or advancing age.
TB Alliance is a not-for-profit product development partnership (PDP) dedicated to the discovery and development of new, faster-acting and affordable tuberculosis (TB) medicines. Since its inception in 2000, TB Alliance has worked to grow the field of available treatments for TB and now manages the largest pipeline of new TB drugs in history. It was founded in Cape Town, South Africa, and has since expanded. It is headquartered in New York City and has a regional office in Pretoria.
Extensively drug-resistant tuberculosis (XDR-TB) is a form of tuberculosis caused by bacteria that are resistant to some of the most effective anti-TB drugs. XDR-TB strains have arisen after the mismanagement of individuals with multidrug-resistant TB (MDR-TB).
Multidrug-resistant tuberculosis (MDR-TB) is a form of tuberculosis (TB) infection caused by bacteria that are resistant to treatment with at least two of the most powerful first-line anti-TB medications (drugs): isoniazid and rifampicin. Some forms of TB are also resistant to second-line medications, and are called extensively drug-resistant TB (XDR-TB).
Bedaquiline, sold under the brand name Sirturo, is a medication used for the treatment of active tuberculosis. Specifically, it is used to treat multi-drug-resistant tuberculosis along with other medications for tuberculosis. It is taken by mouth.
Tuberculosis is a serious public health problem in China. China has the world's third largest cases of tuberculosis, but progress in tuberculosis control was slow during the 1990s. Detection of tuberculosis had stagnated at around 30% of the estimated total of new cases, and multidrug-resistant tuberculosis was a major problem. These signs of inadequate tuberculosis control can be linked to a malfunctioning health system. The spread of severe acute respiratory syndrome (SARS) in 2003, brought to light substantial weaknesses in the country's public health system. After the government realized the impact that the SARS outbreak had on the country, they increased leadership in their health department. After the SARS epidemic was brought under control, the government increased its commitment and leadership to tackle public health problems and, among other efforts, increased public health funding, revised laws that concerned the control of infectious diseases, implemented the world's largest internet-based disease reporting system to improve transparency, reach and speed, and started a program to rebuild local public health facilities and national infrastructure.
In health care facilities, isolation represents one of several measures that can be taken to implement in infection control: the prevention of communicable diseases from being transmitted from a patient to other patients, health care workers, and visitors, or from outsiders to a particular patient. Various forms of isolation exist, in some of which contact procedures are modified, and others in which the patient is kept away from all other people. In a system devised, and periodically revised, by the U.S. Centers for Disease Control and Prevention (CDC), various levels of patient isolation comprise application of one or more formally described "precaution".
Totally drug-resistant tuberculosis (TDR-TB) is a generic term for tuberculosis strains that are resistant to a wider range of drugs than strains classified as extensively drug-resistant tuberculosis. Extensively drug resistant tuberculosis is tuberculosis that is resistant to isoniazid and rifampicin, any fluoroquinolone, and any of the three second line injectable TB drugs. TDR-TB has been identified in three countries; India, Iran, and Italy. The term was first presented in 2006, in which it showed that TB was resistant to many second line drugs and possibly all the medicines used to treat the disease. Lack of testing made it unclear which drugs the TDR-TB were resistant to.
Tuberculosis in India is a major health problem, causing about 220,000 deaths every year. In 2020, the Indian government made statements to eliminate tuberculosis from the country by 2025 through its National TB Elimination Program. Interventions in this program include major investment in health care, providing supplemental nutrition credit through the Nikshay Poshan Yojana, organizing a national epidemiological survey for tuberculosis, and organizing a national campaign to tie together the Indian government and private health infrastructure for the goal of eliminating the disease.
Prisons in Russia consist of four types of facilities: pre-trial institutions; educative or juvenile colonies; corrective colonies; and prisons.
Four laboratory-confirmed cases of Ebola virus disease occurred in the United States in 2014. Eleven cases were reported, including these four cases and seven cases medically evacuated from other countries. The first was reported in September 2014. Nine of the people contracted the disease outside the US and traveled into the country, either as regular airline passengers or as medical evacuees; of those nine, two died. Two people contracted Ebola in the United States. Both were nurses who treated an Ebola patient; both recovered.
The Aeromedical Biological Containment System (ABCS) is an aeromedical evacuation capability devised by the U.S. Centers for Disease Control and Prevention (CDC) in collaboration with the U.S. Department of Defense (DoD) and government contractor Phoenix Air between 2007 and 2010. Its purpose is to safely air-transport a highly contagious patient; it comprises a transit isolator and an appropriately configured supporting aircraft. Originally developed to support CDC staff who might become infected while investigating avian flu and SARS in East Asia, it was never used until the 2014 Ebola virus epidemic in West Africa, transporting 36 Ebola patients out of West Africa.
Zarir Udwadia is an Indian pulmonologist and researcher. His work on drug resistant tuberculosis has led to improvements in India's National Tuberculosis Control Programme. Udwadia was the only Indian invited by the WHO to be part of the TB ‘Guidelines Group’, which formulated the 4th edition of the TB Guidelines, published in 2010. He was also the only doctor to be named among India's best strategists.
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Phumeza Tisile is a healthcare activist from South Africa who advocates for making tuberculosis medication inexpensive and widely available. Tisile survived extensively drug-resistant tuberculosis (XDR-TB), enduring three years and 8 months of treatment. Tisile's initial misdiagnoses led to months of incorrect treatment, which caused her to become deaf. As an activist, Tisile advocates for improved access to tuberculosis (TB) diagnosis and treatment, improved counseling for patients, research into better treatments, and elimination of TB stigma.