Sorana Cîrstea and Anabel Medina Garrigues were the defending champions, but Cîrstea decided not to participate.
Medina Garrigues played alongside Renata Voráčová. They lost to Eleni Daniilidou and Michaëlla Krajicek in the quarterfinal.
Alisa Kleybanova and Galina Voskoboeva became the champions, beating Daniilidou and Krajicek 6–4, 6–2 in the final.
The women's doubles of the 2015 Advantage Cars Prague Open tournament was played on clay in Prague, Czech Republic.
Johanna Konta and Laura Thorpe were the defending champions, but Thorpe chose not to participate, whilst Konta chose to participate in Madrid instead.
Mariana Duque and Julia Glushko were the defending champions, but both players chose not to participate.
Lara Arruabarrena and Andreja Klepač were the defending champions, but Arruabarrena chose not to participate this year and Klepač chose to compete in Tokyo instead.
Margarita Gasparyan and Alexandra Panova were the defending champions, but Gasparyan could not participate due to injury. Panova teamed up with Evgeniya Rodina, but they retired in the first round against Demi Schuurs and Renata Voráčová.
Raquel Atawo and Abigail Spears are the defending champions, but lost in the semifinals to Anna-Lena Grönefeld and Květa Peschke.
Mona Barthel and Laura Siegemund were the defending champions, but Barthel chose not to participate this year. Siegemund played alongside Antonia Lottner, but lost in the first round to Annika Beck and Xenia Knoll.
Elise Mertens and An-Sophie Mestach were the defending champions, but Mestach chose not to participate this year and Mertens chose to compete in Brisbane instead.
Ema Burgić Bucko and Georgina García Pérez were the defending champions from the event's previous edition as an ITF Women's Circuit tournament, but chose not to participate this year.
Andreea Mitu and Demi Schuurs were the defending champions, but both players chose not to participate.
Demi Schuurs and Renata Voráčová were the defending champions, but both players chose not to participate.
Jessica Moore and Varatchaya Wongteanchai were the defending champions, but chose not to compete together. Moore played alongside Prarthana Thombare, but lost in the quarterfinals to Irina-Camelia Begu and Raluca Olaru. Wongteanchai teamed up with Alona Fomina, but lost in the first round to Jaqueline Cristian and Cristina Dinu.
The women's doubles of the 2017 Advantage Cars Prague Open tournament was played on clay in Prague, Czech Republic.
Chuang Chia-jung and Renata Voráčová were the defending champions, however Chuang chose not to participate. Voráčová partnered Xenia Knoll but lost in the quarterfinals to Ysaline Bonaventure and Sara Sorribes Tormo.
Shuko Aoyama and Renata Voráčová were the defending champions, but lost in the quarterfinals to Kristie Ahn and Lauren Davis.
Barbora Krejčíková and Kateřina Siniaková defeated Gabriela Dabrowski and Demi Schuurs in the final, 6–4, 6–3, to win the women's doubles tennis title at the 2021 Madrid Open. It marked the second-seeded duo's first victory in Madrid and their seventh career WTA Tour doubles title together, as well as Krejčíková's eighth individual doubles title and Siniaková's 10th. Dabrowski and Schuurs were competing as a first-time pairing and bidding to win their first title at the tournament; Dabrowski was also aiming for her 10th doubles title and Schuurs, her 15th.
Andrea Sestini Hlaváčková and Lucie Hradecká were the defending champions having won the previous edition in 2013, but Hradecká chose to compete at the 2021 Prague Open instead, whilst Sestini Hlaváčková retired from professional tennis in 2019.
Gabriela Dabrowski and Giuliana Olmos defeated Desirae Krawczyk and Demi Schuurs in the final, 7–6(7–1), 5–7, [10–7] to win the women's doubles tennis title at the 2022 Madrid Open. This was Dabrowski's third consecutive final at the tournament, having lost the previous two editions in 2021 and 2019.
Kaitlyn Christian and Sabrina Santamaria were the defending champions, but chose not to participate together. Christian signed up with Lidziya Marozava, but they withdrew before the start of the tournament because they were still playing at the Madrid Open. Santamaria played alongside Miyu Kato but lost in the quarterfinals to Julia Lohoff and Renata Voráčová.
Demi Schuurs 
Renata Voráčová 
Sílvia Soler Espinosa 
