| Singles | |
|---|---|
| 2016 Cary Challenger | |
| Champion |  James McGee |
| Runner-up |  Ernesto Escobedo |
| Score | 1–6, 6–1, 6–4 |
Dennis Novikov was the defending champion but lost in the semifinals to James McGee.
McGee won the title after defeating Ernesto Escobedo 1–6, 6–1, 6–4 in the final.
Dennis Novikov (semifinals) Frances Tiafoe (semifinals) Austin Krajicek (first round) Stefan Kozlov (quarterfinals)
Peter Polansky (quarterfinals)
Darian King (second round)
Marcelo Arévalo (first round) Ernesto Escobedo (final)| Semifinals | Final | ||||||||||||
| 1 | Dennis Novikov | 6 | 3 | 3 | |||||||||
| Q | James McGee | 3 | 6 | 6 | |||||||||
| Q | James McGee | 1 | 6 | 6 | |||||||||
| 8 | Ernesto Escobedo | 6 | 1 | 4 | |||||||||
| 8 | Ernesto Escobedo | 6 | 65 | 77 | |||||||||
| 2 | Frances Tiafoe | 3 | 77 | 62 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | D Novikov | 78 | 6 | ||||||||||||||||||||||||
 M Lībietis | 66 | 4 | 1 | D Novikov | 6 | 6 | |||||||||||||||||||||
 B Klein | 1 | 7 | 6 | B Klein | 4 | 4 | |||||||||||||||||||||
| S Bangoura | 6 | 5 | 2 | 1 | D Novikov | 6 | 2 | 6 | |||||||||||||||||||
 E Gómez | 6 | 6 | 5 | P Polansky | 3 | 6 | 4 | ||||||||||||||||||||
| WC | Nick Stachowiak | 1 | 3 | E Gómez | 0 | 3 | |||||||||||||||||||||
| M Krueger | 3 | 2 | 5 | P Polansky | 6 | 6 | |||||||||||||||||||||
| 5 | P Polansky | 6 | 6 | 1 | D Novikov | 6 | 3 | 3 | |||||||||||||||||||
| 3 | A Krajicek | 64 | 5 | Q | J McGee | 3 | 6 | 6 | |||||||||||||||||||
| WC | B Schnur | 77 | 7 | WC | B Schnur | 77 | 6 | ||||||||||||||||||||
| E Quigley | 7 | 6 | E Quigley | 61 | 1 | ||||||||||||||||||||||
| R Quiroz | 5 | 3 | WC | B Schnur | 2 | 4 | |||||||||||||||||||||
| Q | J McGee | 7 | 77 | Q | J McGee | 6 | 6 | ||||||||||||||||||||
| E King | 5 | 63 | Q | J McGee | 6 | 6 | |||||||||||||||||||||
 N Scholtz | 4 | 4 | 6 | D King | 1 | 3 | |||||||||||||||||||||
| 6 | D King | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | E Escobedo | 6 | 6 | ||||||||||||||||||||||||
| WC |  Nicholas Horton | 2 | 2 | 8 | E Escobedo | 6 | 5 | 6 | |||||||||||||||||||
| A El Mihdawy | 2 | 65 | WC | R Shane | 3 | 7 | 1 | ||||||||||||||||||||
| WC | R Shane | 6 | 77 | 8 | E Escobedo | 3 | 6 | 6 | |||||||||||||||||||
| P Bester | 7 | 6 | 4 | S Kozlov | 6 | 1 | 2 | ||||||||||||||||||||
| N Meister | 5 | 3 | P Bester | 4 | 1 | ||||||||||||||||||||||
| Q |  Erik Crepaldi | 6 | 4 | 2 | 4 | S Kozlov | 6 | 6 | |||||||||||||||||||
| 4 | S Kozlov | 3 | 6 | 6 | 8 | E Escobedo | 6 | 65 | 77 | ||||||||||||||||||
| 7 | M Arévalo | 4 | 3 | 2 | F Tiafoe | 3 | 77 | 62 | |||||||||||||||||||
| C Norrie | 6 | 6 | C Norrie | 64 | 3 | ||||||||||||||||||||||
| T Sandgren | 6 | 6 | T Sandgren | 77 | 6 | ||||||||||||||||||||||
| Q | M McDonald | 4 | 3 | T Sandgren | 4 | 6 | 65 | ||||||||||||||||||||
| T Paul | 7 | 2 | 4 | 2 | F Tiafoe | 6 | 1 | 77 | |||||||||||||||||||
| M Mmoh | 5 | 6 | 6 | M Mmoh | 7 | 4 | 4 | ||||||||||||||||||||
| Q | Ryan Haviland | 6 | 3 | 62 | 2 | F Tiafoe | 5 | 6 | 6 | ||||||||||||||||||
| 2 | F Tiafoe | 3 | 6 | 77 | |||||||||||||||||||||||
Denis Istomin was the defending champion, but lost in the first round to Damir Džumhur.
Nicolas Mahut was the defending champion and successfully defended his title, defeating Gilles Müller in the final, 6–4, 6–4.
Rajeev Ram was the defending champion, but lost in the second round to Dudi Sela.
Kei Nishikori was the defending champion, but chose not to participate this year.
Second-seeded Gaël Monfils won the title, defeating Ivo Karlović in the final: 5–7, 7–6(8–6), 6–4.
Dennis Novikov was the defending champion but lost in the first round to Evan King.
Tim Smyczek was the defending champion but lost in the semifinals to Michael Mmoh.
This was the first edition of the tennis tournament.
Rafael Nadal defeated Dominic Thiem in the final, 7–6(10–8), 6–4 to win the men's singles tennis title at the 2017 Madrid Open. It was his record fifth Madrid Open title and record-equaling 30th Masters singles title.
Alexander Zverev defeated Novak Djokovic in the final, 6–4, 6–3 to win the men's singles tennis title at the 2017 Italian Open. It was his first Masters 1000 title, and he became the first player born in the 1990s to win a Masters title.
Ernesto Escobedo was the defending champion but chose not to defend his title.
Alexander Zverev defeated Roger Federer in the final, 6–3, 6–4 to win the men's singles tennis title at the 2017 Canadian Open. Zverev saved three match points en route to the title, in his second-round match against Richard Gasquet.
James McGee was the defending champion but chose not to defend his title.
Ernesto Escobedo was the defending champion but lost in the first round to Mats Moraing.
Santiago Giraldo was the defending champion but chose not to defend his title.
Sam Querrey was the defending champion, but lost in the first round to Matthew Ebden.
Two-time defending champion Rafael Nadal defeated Stefanos Tsitsipas in the final, 6–2, 6–1 to win the singles tennis title at the 2018 Barcelona Open. With the win, Nadal retained the ATP no. 1 singles ranking. It was Nadal's record-extending eleventh Barcelona Open title and his 20th ATP 500 title overall, equaling Roger Federer's record. It was Tsitsipas' maiden ATP Tour final.
Kei Nishikori was the defending champion but chose not to defend his title.
Dennis Novikov was the defending champion but lost in the third round to Renzo Olivo.
Matías Franco Descotte and Orlando Luz were the defending champions but chose not to defend their title.
Diego Schwartzman was the reigning champion from when the tournament was last held in 2019, but chose to compete at the Summer Olympics instead.