| Men's singles | |
|---|---|
| 2016 Open Castilla y León | |
| Champion |  Luca Vanni |
| Runner-up |  Illya Marchenko |
| Final score | 6–4, 3–6, 6–3 |
Evgeny Donskoy was the defending champion but chose not to defend his title.
Luca Vanni won the title after defeating Illya Marchenko 6–4, 3–6, 6–3 in the final.
Nicolás Almagro (quarterfinals)
Lukáš Rosol (second round) Illya Marchenko (final)
Marco Chiudinelli (first round)
Mirza Bašić (semifinals)
Jerzy Janowicz (first round)
Kenny de Schepper (quarterfinals)
Márton Fucsovics (semifinals)| Semifinals | Final | ||||||||||||
| 5 | Mirza Bašić | 4 | 3 | ||||||||||
| Luca Vanni | 6 | 6 | |||||||||||
| Luca Vanni | 6 | 3 | 6 | ||||||||||
| 3 | Illya Marchenko | 4 | 6 | 3 | |||||||||
| 3 | Illya Marchenko | 6 | 6 | ||||||||||
| 8 | Márton Fucsovics | 3 | 4 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1/WC | N Almagro | 6 | 6 | ||||||||||||||||||||||||
| M Janvier | 3 | 2 | 1/WC | N Almagro | 7 | 6 | |||||||||||||||||||||
| WC | Ricardo Villacorta-Alonso | 6 | 6 | WC | R Villacorta-Alonso | 5 | 4 | ||||||||||||||||||||
 N Mektić | 4 | 4 | 1/WC | N Almagro | 7 | 65 | 64 | ||||||||||||||||||||
| Michal Konečný | 5 | 6 | 7 | 5 | M Bašić | 5 | 77 | 77 | |||||||||||||||||||
| D Guez | 7 | 2 | 5 | M Konečný | 4 | 3 | |||||||||||||||||||||
| Q |  D Cox | 2 | 2 | 5 | M Bašić | 6 | 6 | ||||||||||||||||||||
| 5 | M Bašić | 6 | 6 | 5 | M Bašić | 4 | 3 | ||||||||||||||||||||
| 4 | M Chiudinelli | 6 | 4 | 3 | L Vanni | 6 | 6 | ||||||||||||||||||||
 A Santillan | 4 | 6 | 6 | A Santillan | 6 | 6 | |||||||||||||||||||||
| WC | Jorge Hernando Ruano | 6 | 6 | WC | J Hernando Ruano | 4 | 0 | ||||||||||||||||||||
 M Safwat | 2 | 3 | A Santillan | 65 | 3 | ||||||||||||||||||||||
 Y Mertens | 6 | 6 | L Vanni | 77 | 6 | ||||||||||||||||||||||
| Pablo Vivero González | 4 | 2 | Y Mertens | 77 | 0 | 3 | |||||||||||||||||||||
| L Vanni | 2 | 77 | 7 | L Vanni | 64 | 6 | 6 | ||||||||||||||||||||
| 6 | J Janowicz | 6 | 63 | 5 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | K de Schepper | 6 | 6 | ||||||||||||||||||||||||
| PR | R Boutillier | 3 | 3 | 7 | K de Schepper | 6 | 6 | ||||||||||||||||||||
 F Horanský | 1 | 3 | R Ortega Olmedo | 3 | 3 | ||||||||||||||||||||||
| R Ortega Olmedo | 6 | 6 | 7 | K de Schepper | 5 | 4 | |||||||||||||||||||||
| R Bemelmans | 6 | 6 | 3 | I Marchenko | 7 | 6 | |||||||||||||||||||||
| Q | Jaume Pla Malfeito | 0 | 3 | R Bemelmans | 3 | 4 | |||||||||||||||||||||
| Q |  A De Minaur | 4 | 4 | 3 | I Marchenko | 6 | 6 | ||||||||||||||||||||
| 3 | I Marchenko | 6 | 6 | 3 | I Marchenko | 6 | 6 | ||||||||||||||||||||
| 8 | M Fucsovics | 77 | 6 | 8 | M Fucsovics | 3 | 4 | ||||||||||||||||||||
| A Sidorenko | 61 | 2 | 8 | M Fucsovics | 6 | 6 | |||||||||||||||||||||
| A Šetkić | 6 | 77 | A Šetkić | 2 | 2 | ||||||||||||||||||||||
| PR | A Olivetti | 3 | 64 | 8 | M Fucsovics | 6 | 67 | 6 | |||||||||||||||||||
| A Menéndez-Maceiras | 63 | 6 | 6 | A Menéndez-Maceiras | 4 | 79 | 4 | ||||||||||||||||||||
 E Struvay | 77 | 2 | 4 | A Menéndez-Maceiras | 6 | 63 | 6 | ||||||||||||||||||||
| Q |  V Durasovic | 4 | 4 | 2 | L Rosol | 3 | 77 | 4 | |||||||||||||||||||
| 2 | L Rosol | 6 | 6 | ||||||||||||||||||||||||
Jo-Wilfried Tsonga was the defending champion, but he was defeated in the semifinals by countryman Julien Benneteau 7–6(13–11), 5–7, 7–6(7–3).
Benedikt Dorsch was the defending champion, but he chose to not start this year.
Mikhail Kukushkin defeated Illya Marchenko 6–4, 6–2 in the final.
Andrey Golubev successfully defended his last year's title. He defeated Illya Marchenko 6–3, 6–3 in the final match.
Robin Söderling defeated Gaël Monfils in the final, 6–1, 7–6(7–1), to win the singles title at the 2010 Paris Masters.
Rubén Ramírez Hidalgo was the defending champion; however, he was eliminated already in the first round by Ivo Klec.
Jerzy Janowicz was the defending champion, but decided to play in Sevilla instead.
Evgeny Donskoy won the title by defeating Illya Marchenko 6–7(6–8), 6–3, 6–2 in the final.
Milos Raonic was the two-time defending champion and won the title for the third year in a row, defeating Tommy Haas in the final 6–4, 6–3.
Dmitry Tursunov was the defending champion but decided not to participate. Mikhail Kukushkin won the title, defeating Illya Marchenko 6–3, 6–3 in the final.
Evgeny Donskoy was the defending champion, but lost to Illya Marchenko in the quarterfinals.
Richard Gasquet was the defending champion, but withdrew before the tournament began.
Marin Čilić won the title, defeating Roberto Bautista Agut in the final, 6–4, 6–4.
Marin Čilić was the two-time defending champion, but withdrew before the tournament started due to an arm injury.
Radu Albot and Dušan Lajović were the defending champions, but Lajović chose not to participate this year. Albot played alongside Illya Marchenko, but lost in the first round to Dominic Inglot and Robert Lindstedt.
Flavio Cipolla and Dudi Sela won the title, defeating Andrés Molteni and Diego Schwartzman in the final, 6–3, 5–7, [10–7].
Roger Federer was the three-time defending champion, but lost in the semifinals to Alexander Zverev.
Mirza Bašić was the defending champion but chose not to participate.
Jordan Thompson was the defending champion but chose not to defend his title.
Illya Marchenko was the defending champion but chose not to defend his title.
Daniil Medvedev was the defending champion, but chose not to defend his title.
Feliciano López was the defending champion from when the event was last held in 2019, but lost in the second round to Denis Shapovalov.
John Millman was the defending champion, but lost in the quarterfinals to James Duckworth.