| Singles | |
|---|---|
| 2017 Prosperita Open | |
| Champion |  Stefano Travaglia |
| Runner-up | Marco Cecchinato |
| Final score | 6–2, 3–6, 6–4 |
Constant Lestienne was the defending champion but retired in the first round against Simone Bolelli.
Stefano Travaglia won the title after defeating Marco Cecchinato 6–2, 3–6, 6–4 in the final.
Norbert Gombos (second round)
Adam Pavlásek (semifinals) Alessandro Giannessi (withdrew)
Roberto Carballés Baena (quarterfinals) Rubén Ramírez Hidalgo (second round) Lukáš Rosol (second round) Jan Šátral (first round) Marco Cecchinato (final)| Semifinals | Final | ||||||||||||
| 8 | Marco Cecchinato | 65 | 6 | 6 | |||||||||
| Q |  Attila Balázs | 77 | 4 | 4 | |||||||||
| 8 | Marco Cecchinato | 2 | 6 | 4 | |||||||||
| Stefano Travaglia | 6 | 3 | 6 | ||||||||||
| Stefano Travaglia | 6 | 7 | |||||||||||
| 2 | Adam Pavlásek | 3 | 5 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | N Gombos | 1 | 6 | 6 | |||||||||||||||||||||||
| R Ojeda Lara | 6 | 3 | 1 | 1 | N Gombos | 2 | 6 | 3 | |||||||||||||||||||
 M Trungelliti | 3 | 7 | 6 | M Trungelliti | 6 | 4 | 6 | ||||||||||||||||||||
 F Krajinović | 6 | 5 | 1 | M Trungelliti | 62 | 3 | |||||||||||||||||||||
 J De Loore | 6 | 65 | 6 | 8 | M Cecchinato | 77 | 6 | ||||||||||||||||||||
| M Zekić | 4 | 77 | 2 | J De Loore | 4 | 3 | |||||||||||||||||||||
 K Mesaroš | 7 | 3 | 3 | 8 | M Cecchinato | 6 | 6 | ||||||||||||||||||||
| 8 | M Cecchinato | 5 | 6 | 6 | 8 | M Cecchinato | 65 | 6 | 6 | ||||||||||||||||||
| LL | C Taberner | 2 | 0 | Q | A Balázs | 77 | 4 | 4 | |||||||||||||||||||
| Q |  S Ofner | 6 | 6 | Q | S Ofner | 5 | 1 | ||||||||||||||||||||
| PR | S Bolelli | 6 | 4 | 5 | PR | S Bolelli | 7 | 6 | |||||||||||||||||||
 C Lestienne | 3 | 6 | 0r | PR | S Bolelli | 77 | 3 | 4 | |||||||||||||||||||
| Q | A Balázs | 6 | 6 | Q | A Balázs | 64 | 6 | 6 | |||||||||||||||||||
| J Samper-Montaña | 2 | 3 | Q | A Balázs | 6 | 6 | |||||||||||||||||||||
 A Šetkić | 3 | 0 | 6 | L Rosol | 3 | 3 | |||||||||||||||||||||
| 6 | L Rosol | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | R Ramírez Hidalgo | 6 | 6 | ||||||||||||||||||||||||
| WC | David Poljak | 3 | 2 | 5 | R Ramírez Hidalgo | 3 | 1 | ||||||||||||||||||||
| S Travaglia | 6 | 6 | S Travaglia | 6 | 6 | ||||||||||||||||||||||
| L Giustino | 1 | 3 | S Travaglia | 2 | 6 | 6 | |||||||||||||||||||||
| Q | Lenny Hampel | 63 | 61 | 4 | R Carballés Baena | 6 | 4 | 4 | |||||||||||||||||||
| Yannik Reuter | 77 | 77 | Y Reuter | 0 | 2 | ||||||||||||||||||||||
| WC | Dominik Kellovský | 5 | 0 | 4 | R Carballés Baena | 6 | 6 | ||||||||||||||||||||
| 4 | R Carballés Baena | 7 | 6 | S Travaglia | 6 | 7 | |||||||||||||||||||||
| 7 | J Šátral | 7 | 3 | 5 | 2 | A Pavlásek | 3 | 5 | |||||||||||||||||||
| LL |  D Dima | 5 | 6 | 7 | LL | D Dima | 1 | 2 | |||||||||||||||||||
| S Napolitano | 6 | 6 | S Napolitano | 6 | 6 | ||||||||||||||||||||||
| Q |  R El Amrani | 1 | 2 | S Napolitano | 6 | 1 | 4 | ||||||||||||||||||||
| WC | Dominik Šproch | 0 | 2 | 2 | A Pavlásek | 2 | 6 | 6 | |||||||||||||||||||
| WC | Z Kolář | 6 | 6 | WC | Z Kolář | 2 | 4 | ||||||||||||||||||||
| M Donati | 2 | 4 | 2 | A Pavlásek | 6 | 6 | |||||||||||||||||||||
| 2 | A Pavlásek | 6 | 6 | ||||||||||||||||||||||||
Pablo Cuevas won the title, defeating Marco Cecchinato in the final, 6–4, 4–6, 6–2.
Fabio Fognini was the defending champion, but lost in the semifinals to Roberto Bautista Agut.
Bautista Agut went on to win the title, defeating Lukáš Rosol in the final, 6–3, 4–6, 6–2.
Tommy Robredo was the defending champion, but lost to Pablo Cuevas in the final, 3–6, 4–6.
Rafael Nadal was the defending champion, but lost in the semifinals to Fabio Fognini.
David Ferrer was the three-time defending champion, but he chose to compete in Acapulco instead.
Rafael Nadal won the title, defeating Juan Mónaco in the final, 6–4, 6–1.
This is the first edition of the tournament.
Lukáš Rosol was the defending champion, but lost to Jerzy Janowicz in the second round. Kevin Anderson won the title defeating in the final Pierre-Hugues Herbert with the score 6–4, 7–5.
Rafael Nadal was the defending champion, but lost to Dominic Thiem in the semifinals.
Pablo Cuevas was the two-time defending champion and successfully defended his title, defeating Albert Ramos Viñolas in the final, 6–7(3–7), 6–4, 6–4.
Alexandr Dolgopolov was the defending champion, but withdrew before the tournament began.
Dominic Thiem was the defending champion, but lost in the quarterfinals to Fernando Verdasco.
Lucas Pouille was the defending champion, but lost in the second round to John Millman.
Andrey Rublev was the defending champion, but lost in the quarterfinals to Robin Haase. This was Rublev's first tournament back on tour after missing three months due to a stress fracture in his back.
This was the first edition of the tournament.
Dominic Thiem was the defending champion, but lost to Diego Schwartzman in the semifinals.
Marco Cecchinato was the defending champion, but withdrew due to illness.
Marco Cecchinato was the defending champion, but lost in the first round to Aljaž Bedene.
Novak Djokovic was the defending champion, but lost to Stefanos Tsitsipas in the quarterfinals.
Stefanos Tsitsipas defeated Andrey Rublev in the final, 6–3, 6–3 to win the singles title at the 2021 Monte-Carlo Masters. It was his first ATP Tour Masters 1000 title, and he became the first Greek man to win a Masters 1000 event.
Alexander Zverev was the defending champion from when the event was held in 2019, but chose not to defend his title.