| Singles | |
|---|---|
| 2018 Cary Challenger | |
| Champion |  James Duckworth |
| Runner-up |  Reilly Opelka |
| Final score | 7–6(7–4), 6–3 |
Kevin King was the defending champion but lost in the first round to James Duckworth.
Duckworth won the title after defeating Reilly Opelka 7–6(7–4), 6–3 in the final.
Peter Polansky (first round)
Elias Ymer (first round)
Marcelo Arévalo (second round) Reilly Opelka (final) Bjorn Fratangelo (semifinals) Kevin King (first round) Alexei Popyrin (second round) Maverick Banes (first round)| Semifinals | Final | ||||||||||||
| 5 | Bjorn Fratangelo | 3 | 4 | ||||||||||
| Q | James Duckworth | 6 | 6 | ||||||||||
| Q | James Duckworth | 77 | 6 | ||||||||||
| 4 | Reilly Opelka | 64 | 3 | ||||||||||
| 4 | Reilly Opelka | 6 | 6 | ||||||||||
 Kaichi Uchida | 3 | 4 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | P Polansky | 3 | 4 | ||||||||||||||||||||||||
 A González | 6 | 6 | A González | 4 | 6 | 6 | |||||||||||||||||||||
| M Ymer | 6 | 2 | 77 | M Ymer | 6 | 3 | 4 | ||||||||||||||||||||
 D Pérez Sanz | 2 | 6 | 62 | A González | 77 | 5 | 4 | ||||||||||||||||||||
| M Krueger | 3 | 77 | 3 | 5 | B Fratangelo | 65 | 7 | 6 | |||||||||||||||||||
| C Eubanks | 6 | 63 | 6 | C Eubanks | 4 | 4 | |||||||||||||||||||||
| WC | A Galarneau | 4 | 3 | 5 | B Fratangelo | 6 | 6 | ||||||||||||||||||||
| 5 | B Fratangelo | 6 | 6 | 5 | B Fratangelo | 3 | 4 | ||||||||||||||||||||
| 3 | M Arévalo | 6 | 6 | Q | J Duckworth | 6 | 6 | ||||||||||||||||||||
| Q | JJ Wolf | 3 | 3 | 3 | M Arévalo | 63 | 5 | ||||||||||||||||||||
| WC | S Korda | 63 | 4 | Q |  J De Loore | 77 | 7 | ||||||||||||||||||||
| Q | J De Loore | 77 | 6 | Q | J De Loore | 3 | 63 | ||||||||||||||||||||
| Q | Evan Song | 6 | 6 | Q | J Duckworth | 6 | 77 | ||||||||||||||||||||
| WC | Nick Stachowiak | 3 | 2 | Q | E Song | 3 | 64 | ||||||||||||||||||||
| Q | J Duckworth | 4 | 6 | 6 | Q | J Duckworth | 6 | 77 | |||||||||||||||||||
| 6 | K King | 6 | 4 | 3 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | A Popyrin | 6 | 6 | ||||||||||||||||||||||||
| JC Aragone | 3 | 4 | 7 | A Popyrin | 77 | 65 | 63 | ||||||||||||||||||||
| R Ortega Olmedo | 6 | 5 | 1 |  D Köpfer | 65 | 77 | 77 | ||||||||||||||||||||
| D Köpfer | 3 | 7 | 6 | D Köpfer | 64 | 4 | |||||||||||||||||||||
| J Choinski | 77 | 2 | 1 | 4 | R Opelka | 77 | 6 | ||||||||||||||||||||
| D Young | 64 | 6 | 6 | D Young | 1 | 65 | |||||||||||||||||||||
| E Escobedo | 611 | 4 | 4 | R Opelka | 6 | 77 | |||||||||||||||||||||
| 4 | R Opelka | 713 | 6 | 4 | R Opelka | 6 | 6 | ||||||||||||||||||||
| 8 | M Banes | 2 | 6 | 3 | K Uchida | 3 | 4 | ||||||||||||||||||||
| E King | 6 | 1 | 6 | E King | 4 | 3 | |||||||||||||||||||||
 R Cid Subervi | 3 | 1 | K Uchida | 6 | 6 | ||||||||||||||||||||||
| K Uchida | 6 | 6 | K Uchida | 6 | 6 | ||||||||||||||||||||||
| WC | W Blumberg | 65 | 6 | 0 | J Hernández-Fernández | 4 | 3 | ||||||||||||||||||||
| A Harris | 77 | 3 | 0r | WC | W Blumberg | 4 | 3 | ||||||||||||||||||||
| J Hernández-Fernández | 6 | 6 | J Hernández-Fernández | 6 | 6 | ||||||||||||||||||||||
| 2 | E Ymer | 3 | 4 | ||||||||||||||||||||||||
Orlando Luz and Marcelo Zormann were the defending champions, but they chose to participate at the Pan American Games instead.
Jack Sock was the defending champion, but lost in the final to Juan Mónaco, 6–3, 3–6, 5–7.
Tomáš Berdych was the two-time defending champion, but withdrew before the competition began.
Jack Sock was the defending champion, but lost in the second round to Reilly Opelka.
Akira Santillan was the defending champion but chose not to defend his title.
Filip Peliwo was the defending champion but chose not to defend his title.
Tim Smyczek was the defending champion but chose not to defend his title.
Kevin Anderson was the defending champion, but withdrew before the tournament began because of a right elbow injury.
John Isner was the two-time defending champion and had won the title five times in the last six years, but he lost in the second round to Reilly Opelka. This was only the second time out of ten in the Atlanta Open's history that Isner failed to reach the singles final.
Dominic Inglot and Franko Škugor were the defending champions, but Inglot decided to compete in Vienna instead. Škugor played alongside Nikola Mektić, but they lost to Jean-Julien Rojer and Horia Tecău in the first round.
Reilly Opelka was the defending champion but chose not to defend his title.
Reilly Opelka was the defending champion but chose not to defend his title.
Kevin Krawietz and Andreas Mies were the defending champions but chose to compete in Rotterdam instead.
Reilly Opelka was the defending champion, but lost to Jason Jung in the quarterfinals.
Reilly Opelka was the defending champion, but withdrew from the event.
Taylor Fritz was the defending champion from when the event was last held in 2019, but withdrew before the tournament with a knee injury.
Daniil Medvedev won the title, defeating Reilly Opelka in the final, 6–4, 6–3. It was his fourth ATP Masters 1000 title and 12th career title.
Aslan Karatsev defeated Andy Murray in the final, 6–3, 6–3 to win the men's singles title at the 2022 Sydney International. This was Murray's first ATP final since he won the 2019 European Open.
Reilly Opelka defeated Jenson Brooksby in the final, 7–6(7–5), 7–6(7–3) to win the singles title at the 2022 Dallas Open. This was the first edition of the tournament.
Cameron Norrie defeated Reilly Opelka in the final, 7–6(7–1), 7–6(7–4) to win the singles title at the 2022 Delray Beach Open.