| Singles | |
|---|---|
| 2018 Garden Open | |
| Champion |  Adam Pavlásek |
| Runner-up |  Laslo Đere |
| Score | 7–6(7–1), 6–7(9–11), 6–4 |
Marco Cecchinato was the defending champion but chose not to defend his title.
Adam Pavlásek won the title after defeating Laslo Đere 7–6(7–1), 6–7(9–11), 6–4 in the final.
Ruben Bemelmans (second round) Laslo Đere (final)
Taro Daniel (withdrew)
Yannick Maden (withdrew)
Rogério Dutra Silva (quarterfinals)
Quentin Halys (first round)
Jozef Kovalík (second round)
Simone Bolelli (quarterfinals, withdrew)| Semifinals | Final | ||||||||||||
| WC | Gianluigi Quinzi | 77 | 3 | 5 | |||||||||
| Adam Pavlásek | 64 | 6 | 7 | ||||||||||
| Adam Pavlásek | 77 | 69 | 6 | ||||||||||
| 2 | Laslo Đere | 61 | 711 | 4 | |||||||||
| Q | Kevin Krawietz | 2 | 2 | ||||||||||
| 2 | Laslo Đere | 6 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | R Bemelmans | 6 | 6 | ||||||||||||||||||||||||
| A Arnaboldi | 4 | 2 | 1 | R Bemelmans | 6 | 1 | 2 | ||||||||||||||||||||
| WC | G Quinzi | 6 | 6 | WC | G Quinzi | 4 | 6 | 6 | |||||||||||||||||||
| LL | R Marcora | 4 | 4 | WC | G Quinzi | 6 | 6 | ||||||||||||||||||||
 JI Londero | 77 | 6 | 5/Alt | R Dutra Silva | 4 | 4 | |||||||||||||||||||||
| Q |  B Zapata Miralles | 60 | 3 | JI Londero | 65 | 4 | |||||||||||||||||||||
| V Millot | 3 | 1 | 5/Alt | R Dutra Silva | 77 | 6 | |||||||||||||||||||||
| 5/Alt | R Dutra Silva | 6 | 6 | WC | G Quinzi | 77 | 3 | 5 | |||||||||||||||||||
| LL | Patricio Heras | 6 | 3 | 7 | A Pavlásek | 64 | 6 | 7 | |||||||||||||||||||
| WC | G Fonio | 4 | 6 | 5 | LL | P Heras | 79 | 6 | |||||||||||||||||||
| WC | Riccardo Balzerani | 3 | 77 | 4 |  V Galović | 67 | 0 | ||||||||||||||||||||
| V Galović | 6 | 64 | 6 | LL | P Heras | 65 | 1 | ||||||||||||||||||||
| SE | M Viola | 2 | 4 | A Pavlásek | 77 | 6 | |||||||||||||||||||||
| A Giannessi | 6 | 6 | A Giannessi | 4 | 1 | ||||||||||||||||||||||
| A Pavlásek | 6 | 4 | 6 | A Pavlásek | 6 | 6 | |||||||||||||||||||||
| 6 | Q Halys | 4 | 6 | 1 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | J Kovalík | 7 | 6 | ||||||||||||||||||||||||
| A Martin | 5 | 4 | 7 | J Kovalík | 63 | 7 | 3 | ||||||||||||||||||||
| V Šafránek | 1 | 6 | 6 | V Šafránek | 77 | 5 | 6 | ||||||||||||||||||||
| M Donati | 6 | 2 | 3 | V Šafránek | 65 | 63 | |||||||||||||||||||||
| Q | K Krawietz | 6 | 6 | Q | K Krawietz | 77 | 77 | ||||||||||||||||||||
| Q |  A Haider-Maurer | 1 | 3 | Q | K Krawietz | 3 | 77 | 6 | |||||||||||||||||||
| R Olivo | 6 | 6 | R Olivo | 6 | 62 | 3 | |||||||||||||||||||||
| Q | Í Cervantes | 2 | 2 | Q | K Krawietz | 2 | 2 | ||||||||||||||||||||
| 8 | S Bolelli | 6 | 77 | 2 | L Đere | 6 | 6 | ||||||||||||||||||||
| M Trungelliti | 2 | 61 | 8 | S Bolelli | 6 | 6 | |||||||||||||||||||||
| LL | Alberto Romero de Ávila Senise | 67 | 0 |  M Safwat | 1 | 4 | |||||||||||||||||||||
| M Safwat | 79 | 6 | 8 | S Bolelli | |||||||||||||||||||||||
 T Brkić | 6 | 4 | 6 | 2 | L Đere | w/o | |||||||||||||||||||||
| Z Kolář | 1 | 6 | 0 | T Brkić | 65 | 6 | 5 | ||||||||||||||||||||
| WC | R Brancaccio | 4 | 2 | 2 | L Đere | 77 | 3 | 7 | |||||||||||||||||||
| 2 | L Đere | 6 | 6 | ||||||||||||||||||||||||
Dušan Lajović was the defending champion but chose not to defend his title.
Damir Džumhur was the defending champion but lost in the second round to Gianluca Mager.
Horacio Zeballos was the defending champion but chose not to defend his title.
Jan Šátral was the defending champion but chose not to defend his title.
Jo-Wilfried Tsonga was the defending champion, but due to injury did not defend his title.
Paolo Lorenzi was the defending champion but lost in the first round to Alejandro Davidovich Fokina.
Roger Federer was the defending champion and successfully defended his title, defeating Marius Copil in the final, 7–6(7–5), 6–4.
Roberto Bautista Agut was the defending champion, but withdrew before the tournament began.
Marco Cecchinato was the defending champion, but withdrew due to illness.
Juan Ignacio Londero was the defending champion, but lost to Laslo Đere in the quarterfinals.
Marco Cecchinato was the defending champion, but lost in the first round to Roberto Carballés Baena.
Laslo Đere was the defending champion, but withdrew with an abdominal injury before the tournament began.
Dominic Thiem was the defending champion and chose not to defend his title, as he was still competing at the 2020 US Open.
Tommy Robredo was the defending champion but chose not to defend his title.
Daniil Medvedev defeated Alexander Zverev in the final, 5–7, 6–4, 6–1 to win the singles tennis title at the 2020 Paris Masters.
Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
Miomir Kecmanović was the defending champion, but chose to compete at the Summer Olympics instead.
Novak Djokovic defeated Stefanos Tsitsipas in the final, 6–0, 7–6(7–5) to win the men's singles tennis title at the 2022 Italian Open. It was his sixth Italian Open title and record-extending 38th Masters 1000 title overall. Djokovic did not lose a set during the tournament, and won his 1000th ATP Tour-level career match against Casper Ruud in the semifinals.
Adrian Mannarino defeated Laslo Đere in the final, 7–6(7–1), 6–4 to win the singles tennis title at the 2022 Winston-Salem Open. Mannarino saved four match points en route to the title, in his first-round match against Christopher O'Connell.
Novak Djokovic defeated Stefanos Tsitsipas in the final, 6–3, 6–4 to win the singles tennis title at the 2022 Astana Open. It was his 90th ATP Tour-level singles title.