| Doubles | |
|---|---|
| 2018 Internazionali di Tennis Città di Perugia | |
| Champions |  Daniele Bracciali Matteo Donati |
| Runners-up |  Tomislav Brkić  Ante Pavić |
| Final score | 6–3, 3–6, [10–7] |
Salvatore Caruso and Jonathan Eysseric were the defending champions but chose not to defend their title.
Daniele Bracciali and Matteo Donati won the title after defeating Tomislav Brkić and Ante Pavić 6–3, 3–6, [10–7] in the final.
Ariel Behar / 
David Vega Hernández (quarterfinals, withdrew) Tomislav Draganja / Ivan Sabanov (first round)
Sergio Galdós / 
Federico Zeballos (first round)
Gonzalo Escobar / 
Fernando Romboli (first round)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | A Behar D Vega Hernández | 6 | 77 | ||||||||||||||||||||||||
 H Hach Verdugo  T Khabibulin | 4 | 64 | 1 | A Behar D Vega Hernández | |||||||||||||||||||||||
| WC | Riccardo Balzerani G Fonio | 3 | 3 | PR | D Bracciali M Donati | w/o | |||||||||||||||||||||
| PR | D Bracciali M Donati | 6 | 6 | PR | D Bracciali M Donati | 6 | 63 | [10] | |||||||||||||||||||
| 4 | G Escobar F Romboli | 6 | 3 | [6] | F Gaio A Pellegrino | 2 | 77 | [3] | |||||||||||||||||||
 N Čačić  L Margaroli | 2 | 6 | [10] | N Čačić L Margaroli | 4 | 5 | |||||||||||||||||||||
| WC | Alessio De Bernardis M Delić | 2 | 62 | F Gaio A Pellegrino | 6 | 7 | |||||||||||||||||||||
| F Gaio A Pellegrino | 6 | 77 | PR | D Bracciali M Donati | 6 | 3 | [10] | ||||||||||||||||||||
| N Milojević A Motti | 5 | 2 | T Brkić A Pavić | 3 | 6 | [7] | |||||||||||||||||||||
| T Brkić A Pavić | 7 | 6 | T Brkić A Pavić | 6 | 6 | ||||||||||||||||||||||
 LD Martínez R Ojeda Lara | 6 | 6 | LD Martínez R Ojeda Lara | 3 | 4 | ||||||||||||||||||||||
| 3 | S Galdós F Zeballos | 3 | 4 | T Brkić A Pavić | 6 | 7 | |||||||||||||||||||||
| WC | J Berrettini Enrico Dalla Valle | 4 | 6 | [10] | WC | J Berrettini E Dalla Valle | 1 | 5 | |||||||||||||||||||
E López Pérez  M Trungelliti | 6 | 3 | [8] | WC | J Berrettini E Dalla Valle | w/o | |||||||||||||||||||||
| PR | N Almagro B Zapata Miralles | 7 | 7 | PR | N Almagro B Zapata Miralles | ||||||||||||||||||||||
| 2 | T Draganja I Sabanov | 5 | 5 | ||||||||||||||||||||||||
Sanchai and Sonchat Ratiwatana were the defending champions but only Sanchai Ratiwatana chose to defend his title, partnering Peng Hsien-yin. Ratiwatana lost in the first round to Masahiro Fukuda and Masamichi Imamura.
Martin Kližan and David Marrero were the defending champions, but Kližan chose not to participate this year and Marrero chose to compete in Båstad instead.
Dino Marcan and Tristan-Samuel Weissborn were the defending champions but chose not to defend their title.
Mateusz Kowalczyk and Andreas Mies were the defending champions but chose not to defend their title.
Roman Jebavý and Zdeněk Kolář were the defending champions but only Kolář chose to defend his title, partnering Aldin Šetkić. Kolář lost in the first round to Nikola Čačić and Luca Margaroli.
Marin and Tomislav Draganja were the defending champions but only Tomislav chose to defend his title, partnering Alessandro Giannessi. Tomislav Draganja lost in the quarterfinals to Andrej Martin and Hans Podlipnik Castillo.
Gerard and Marcel Granollers were the defending champions but chose not to defend their title.
Denys Molchanov and Igor Zelenay were the defending champions and successfully defended their title, defeating Tomislav Brkić and Tomislav Draganja 7–6(7–1), 6–4 in the final.
Denys Molchanov and Igor Zelenay were the defending champions but chose not to defend their title.
Daniele Bracciali and Matteo Donati were the defending champions but chose not to defend their title.
Filippo Baldi and Andrea Pellegrino were the defending champions but chose not to defend their title.
Sander Gillé and Joran Vliegen were the defending champions but chose not to defend their title.
Fabrice Martin and Hugo Nys were the defending champions but chose not to defend their title.
Marcelo Demoliner and Matwé Middelkoop were the defending champions, but Middelkoop decide to participate in the 2021 Open Sud de France instead. Demoliner was pairing up with Santiago González, but they lost in the first round to Guillermo Durán and Andrés Molteni.
Marcel Granollers and Horacio Zeballos were the defending champions, but they decided not to participate this year.
Oliver Marach and Mate Pavić were the two-time defending champions from when the event was last held in 2019 but lost in the first round to Tomislav Brkić and Nikola Ćaćić.
John Peers and Michael Venus were the defending champions, but Peers chose not to participate this year.
Robin Haase and Philipp Oswald were the reigning champions from when the tournament was last held in 2019, but chose not to defend their title.
Jamie Murray and Neal Skupski were the defending champions, but chose to compete in San Diego with different partners instead.
Marcelo Demoliner and Matwé Middelkoop were the reigning champions from when the tournament was last held in 2019, but chose to compete with different partners. Demoliner played alongside Marcus Daniell, but lost in the first round to Ariel Behar and Gonzalo Escobar.