Asia Muhammad and Yasmin Schnack were the defending champions, having won the event in 2012, but both decided not to defend the title together as a team. Muhammad partnered up with Maria Sanchez as the first seeds whilst Schnack received a wildcard with Kelly Wilson. Schnack and Wilson lost in the first round; Muhammad and Schnack lost in the quarterfinals.
Samantha Crawford and Madison Keys were the defending champions, having won the event in 2012, but both players chose not to defend their title. Jan Abaza and Allie Will won the title, defeating Naomi Broady and Irina Falconi in the final, 7–5, 3–6, [10–3].
Junri Namigata and Erika Sema were the defending champions, having won the event in 2013, however both players chose to defend their titles with different partners. Namigata partnered with Akiko Yonemura but lost in the quarterfinals whilst Sema partnered with Miki Miyamura but lost in the first round.
Naomi Broady and Storm Sanders were the defending champions, having won the event in 2013, but Broady chose not to participate. Sanders partnered with Daria Gavrilova and successfully defended her title, defeating Maria Sanchez and Zoë Gwen Scandalis in the final, 6–2, 6–1.
Sharon Fichman and Maryna Zanevska were the defending champions, but both players chose not to participate.
Julie Coin and Emily Webley-Smith were the defending champions, but Coin retired from professional tennis at the end of 2015. Webley-Smith partnered Riko Sawayanagi, but they lost in the first round.
Anna Kalinskaya and Tereza Mihalíková were the defending champions, but Kalinskaya chose to participate in Saint-Gaudens instead. Mihalíková partnered Chantal Škamlová, but they lost in the first round to Chuang Chia-jung and Renata Voráčová.
Sanaz Marand and Melanie Oudin were the defending champions, but both players chose not to participate.
Andrea Hlaváčková and Lucie Hradecká were the defending champions, but decided not to compete together. Hradecká partnered with Barbora Krejčíková, but lost in the quarterfinals to Bianca Andreescu and Carson Branstine. Hlaváčková partnered with Tímea Babos and successfully defended her title, defeating Andreescu and Branstine 6–3, 6–1 in the final.
Jessica Moore and Storm Sanders were the defending champions, but both players chose to participate with different partners. Sanders played alongside Gabriella Da Silva-Fick, but lost in the first round to Destanee Aiava and Alicia Smith. Moore played alongside Ellen Perez, however they lost in the final to Asia Muhammad and Arina Rodionova, 6–4, 6–4.
Eri Hozumi and Miyu Kato were the defending champions, but Kato chose to compete at the 2018 J&T Banka Prague Open. Hozumi chose to partner Makoto Ninomiya but lost in the semifinals to Ksenia Lykina and Emily Webley-Smith.
Junri Namigata and Kotomi Takahata were the defending champions, but both players chose to participate with different partners. Namigata partnered Arina Rodionova, while Takahata played alongside Megumi Nishimoto. Takahata and Nishimoto beat Namigata and Rodionova in the first round, however they lost to Tara Moore and Amra Sadiković in the quarterfinals.
The 2018 Kurume U.S.E Cup was a professional tennis tournament played on outdoor carpet courts. It was the fourteenth edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Kurume, Japan, on 14–20 May 2018.
Magdalena Fręch and An-Sophie Mestach were the defending champions, however Fręch chose to participate at Nottingham instead. Mestach partnered alongside Jamie Loeb, but lost in the semifinals to Naomi Broady and Asia Muhammad.
An-Sophie Mestach and Laura Robson were the defending champions, but both players chose not to participate.
Naomi Broady and Sara Sorribes Tormo were the defending champions, but Broady chose not to participate and Sorribes Tormo chose to compete in Charleston instead.
Naomi Broady and Asia Muhammad were the defending champions, but Muhammad chose to participate at the 2019 FineMark Women's Pro Tennis Championship instead.
Naomi Broady and Asia Muhammad were the defending champions, but Muhammad chose not to participate. Broady partnered alongside Ayaka Okuno but lost in the first round to Emina Bektas and Tara Moore.
Jessica Moore and Ellen Perez were the defending champions, but chose to participate with different partners. Moore partnered alongside Monique Adamczak but lost in the first round to Viktorija Golubic and Ingrid Neel. Perez partnered alongside Arina Rodionova but lost in the first round to Naiktha Bains and Naomi Broady.
Luksika Kumkhum and Prarthana Thombare were the defending champions, but Kumkhum chose not to participate. Thombare partnered alongside Tereza Smitková, but lost in the first round to Quinn Gleason and Ingrid Neel.
Naomi Broady 
Asia Muhammad 
Abigail Tere-Apisah 
