| Singles | |
|---|---|
| 2018 Savannah Challenger | |
| Champion |  Hugo Dellien |
| Runner-up |  Christian Harrison |
| Score | 6–1, 1–6, 6–4 |
Tennys Sandgren was the defending champion but chose not to defend his title.
Hugo Dellien won the title after defeating Christian Harrison 6–1, 1–6, 6–4 in the final.
Denis Kudla (first round)
Peter Polansky (first round) Donald Young (first round)
Henri Laaksonen (first round) Michael Mmoh (semifinals)
Blaž Rola (first round) Hugo Dellien (champion) Evan King (first round)| Semifinals | Final | ||||||||||||
| 5 | Michael Mmoh | 6 | 5 | 3 | |||||||||
| 7 | Hugo Dellien | 1 | 7 | 6 | |||||||||
| 7 | Hugo Dellien | 6 | 1 | 6 | |||||||||
| Christian Harrison | 1 | 6 | 4 | ||||||||||
| Reilly Opelka | 5 | 2 | |||||||||||
| Christian Harrison | 7 | 6 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | D Kudla | 6 | 4 | 4 | |||||||||||||||||||||||
 M Purcell | 3 | 6 | 6 | M Purcell | 6 | 6 | |||||||||||||||||||||
 M Kecmanović | 4 | 4 | Q |  F Coria | 3 | 2 | |||||||||||||||||||||
| Q | F Coria | 6 | 6 | M Purcell | 3 | 2 | |||||||||||||||||||||
| WC | F Dancevic | 6 | 6 | 5 | M Mmoh | 6 | 6 | ||||||||||||||||||||
| M Krueger | 4 | 4 | WC | F Dancevic | 4 | 2 | |||||||||||||||||||||
| SE | N Rubin | 4 | 66 | 5 | M Mmoh | 6 | 6 | ||||||||||||||||||||
| 5 | M Mmoh | 6 | 78 | 5 | M Mmoh | 6 | 5 | 3 | |||||||||||||||||||
| 4 | H Laaksonen | 0 | 4 | 7 | H Dellien | 1 | 7 | 6 | |||||||||||||||||||
 E López Pérez | 6 | 6 | E López Pérez | 6 | 64 | 4 | |||||||||||||||||||||
 G Clezar | 6 | 6 | G Clezar | 0 | 77 | 6 | |||||||||||||||||||||
 D Köpfer | 2 | 3 | G Clezar | 7 | 4 | 66 | |||||||||||||||||||||
| WC | S Riffice | 6 | 4 | 2 | 7 | H Dellien | 5 | 6 | 78 | ||||||||||||||||||
| M Polmans | 1 | 6 | 6 | M Polmans | 64 | 4 | |||||||||||||||||||||
| J Choinski | 6 | 1 | 2 | 7 | H Dellien | 77 | 6 | ||||||||||||||||||||
| 7 | H Dellien | 2 | 6 | 6 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | E King | 2 | 1 | ||||||||||||||||||||||||
| Q | Karue Sell | 6 | 6 | Q | K Sell | 63 | 4 | ||||||||||||||||||||
| Q |  M Cuevas | 6 | 6 | Q | M Cuevas | 77 | 6 | ||||||||||||||||||||
| WC | T Bryde | 1 | 4 | Q | M Cuevas | 3 | 4 | ||||||||||||||||||||
| R Opelka | 6 | 6 | R Opelka | 6 | 6 | ||||||||||||||||||||||
| WC | S Kirchheimer | 4 | 3 | R Opelka | 6 | 6 | |||||||||||||||||||||
 C Garín | 6 | 4 | 6 | C Garín | 4 | 4 | |||||||||||||||||||||
| 3 | D Young | 3 | 6 | 1 | R Opelka | 5 | 2 | ||||||||||||||||||||
| 6 | B Rola | 6 | 5 | 4 | C Harrison | 7 | 6 | ||||||||||||||||||||
| C Harrison | 2 | 7 | 6 | C Harrison | 77 | 6 | |||||||||||||||||||||
| A Santillan | 6 | 1 | 63 |  A Arnaboldi | 64 | 3 | |||||||||||||||||||||
| A Arnaboldi | 3 | 6 | 77 | C Harrison | 7 | 6 | |||||||||||||||||||||
 J Clarke | 3 | 6 | 6 | T Bellucci | 5 | 4 | |||||||||||||||||||||
| Q | JP Sorgi | 6 | 3 | 2 | J Clarke | 77 | 3 | 3 | |||||||||||||||||||
| T Bellucci | 6 | 6 | T Bellucci | 63 | 6 | 6 | |||||||||||||||||||||
| 2 | P Polansky | 3 | 1 | ||||||||||||||||||||||||
Jack Sock was the defending champion, but participated in the men's main draw, as he was ineligible to defend his title.
Ariel Behar and Fabiano de Paula were the defending champions but chose to defend their title with different partners. Behar partnered Attila Balázs but lost in the semifinals to Marcelo Arévalo and Miguel Ángel Reyes-Varela. De Paula partnered Sergio Galdós but lost in the first round to Hugo Dellien and Federico Zeballos.
Márton Fucsovics was the defending champion but chose not to defend his title.
Filip Krajinović was the defending champion but chose not to defend his title.
Dominic Thiem was the defending champion, but lost to Diego Schwartzman in the semifinals.
Diego Schwartzman was the defending champion, but he retired in the first round against Pablo Cuevas.
Nikoloz Basilashvili was the defending champion and successfully defended his title, defeating Andrey Rublev in the final, 7–5, 4–6, 6–3. En route to doing so, Basilashvili saved two match points against Alexander Zverev in the semifinals.
Martin Kližan was the defending champion but lost in the first round to Matthias Bachinger.
Roger Federer was the two-time defending champion and successfully defended his title, defeating Alex de Minaur in the final, 6–2, 6–2. He did not lose a single set in the entire tournament. The victory made Federer the first player in ATP history to win 10 same tournament titles on two different surfaces. It was his 103rd and final ATP title before announcing his retirement in 2022.
Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
Hugo Dellien was the defending champion but chose not to defend his title.
Henri Laaksonen was the defending champion but chose not to defend his title.
Daniel Masur was the defending champion but chose not to defend his title.
Hugo Dellien was the defending champion but chose not to defend his title.
Daniel Elahi Galán was the defending champion but chose not to defend his title.
Hugo Dellien was the defending champion but lost in the quarterfinals to Juan Manuel Cerúndolo.
Jaume Munar was the defending champion but lost in the semifinals to Juan Ignacio Londero.
Casper Ruud defeated the defending champion Diego Schwartzman in the final, 5–7, 6–2, 6–3 to win the singles title at the 2022 Argentina Open.
Sebastián Báez was the defending champion but chose not to defend his title.
Sebastián Báez defeated Frances Tiafoe in the final, 6–3, 6–2 to win the singles tennis title at the 2022 Estoril Open. It was his maiden ATP Tour title.