| Singles | |
|---|---|
| 2020 Challenger Ciudad de Guayaquil | |
| Champion |  Francisco Cerúndolo |
| Runner-up |  Andrej Martin |
| Final score | 6–4, 3–6, 6–2 |
Thiago Seyboth Wild was the defending champion [1] but chose not to defend his title.
Francisco Cerúndolo won the title after defeating Andrej Martin 6–4, 3–6, 6–2 in the final.
Federico Coria (first round)
Roberto Carballés Baena (semifinals) Andrej Martin (final) Jaume Munar (quarterfinals)
Pedro Sousa (quarterfinals)
Juan Pablo Varillas (second round)
Emilio Gómez (first round)
Alejandro Tabilo (second round)| Semifinals | Final | ||||||||||||
| Q |  Jesper de Jong | 3 | 6 | 3 | |||||||||
| 3 | Andrej Martin | 6 | 2 | 6 | |||||||||
| 3 | Andrej Martin | 4 | 6 | 2 | |||||||||
| Francisco Cerúndolo | 6 | 3 | 6 | ||||||||||
| Francisco Cerúndolo | 6 | 6 | |||||||||||
| 2 | Roberto Carballés Baena | 2 | 1 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | F Coria | 67 | 77 | 68 | |||||||||||||||||||||||
| Q | O Roca Batalla | 79 | 62 | 710 | Q | O Roca Batalla | 6 | 6 | |||||||||||||||||||
| WC | D Hidalgo | 3 | 65 | WC | G Escobar | 4 | 3 | ||||||||||||||||||||
| WC | G Escobar | 6 | 77 | Q | O Roca Batalla | 2 | 2 | ||||||||||||||||||||
| Q | J de Jong | 5 | 6 | 7 | Q | J de Jong | 6 | 6 | |||||||||||||||||||
| M Vilella Martínez | 7 | 3 | 5 | Q | J de Jong | 6 | 6 | ||||||||||||||||||||
 J Menezes | 3 | 5 | 8 | A Tabilo | 2 | 2 | |||||||||||||||||||||
| 8 | A Tabilo | 6 | 7 | Q | J de Jong | 3 | 6 | 3 | |||||||||||||||||||
| 3 | A Martin | 6 | 7 | 3 | A Martin | 6 | 2 | 6 | |||||||||||||||||||
| R Ortega Olmedo | 4 | 5 | 3 | A Martin | 6 | 6 | |||||||||||||||||||||
| MT Barrios Vera | 6 | 6 | MT Barrios Vera | 4 | 1 | ||||||||||||||||||||||
| Q | TA Tirante | 3 | 2 | 3 | A Martin | 6 | 6 | ||||||||||||||||||||
| S Báez | 7 | 77 | S Báez | 4 | 4 | ||||||||||||||||||||||
| R Quiroz | 5 | 61 | S Báez | 77 | 6 | ||||||||||||||||||||||
| F Mena | 3 | 79 | 6 | F Mena | 64 | 2 | |||||||||||||||||||||
| 7 | E Gómez | 6 | 67 | 2 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | JP Varillas | 7 | 6 | ||||||||||||||||||||||||
| F Meligeni Alves | 5 | 4 | 6 | JP Varillas | 1 | 711 | 62 | ||||||||||||||||||||
| F Cerúndolo | 6 | 6 | F Cerúndolo | 6 | 69 | 77 | |||||||||||||||||||||
| P Sakamoto | 3 | 3 | F Cerúndolo | 4 | 6 | 6 | |||||||||||||||||||||
| WC | AC March | 65 | 4 | 4 | J Munar | 6 | 4 | 2 | |||||||||||||||||||
 C Lindell | 77 | 6 | C Lindell | 0 | 6 | 4 | |||||||||||||||||||||
| JP Ficovich | 7 | 4 | 2 | 4 | J Munar | 6 | 4 | 6 | |||||||||||||||||||
| 4 | J Munar | 5 | 6 | 6 | F Cerúndolo | 6 | 6 | ||||||||||||||||||||
| 5 | P Sousa | 2 | 6 | 6 | 2 | R Carballés Baena | 2 | 1 | |||||||||||||||||||
| TM Etcheverry | 6 | 4 | 4 | 5 | P Sousa | 1 | 6 | 6 | |||||||||||||||||||
 V Kopřiva | 6 | 6 | V Kopřiva | 6 | 3 | 4 | |||||||||||||||||||||
 P Krstin | 1 | 4 | 5 | P Sousa | 4 | 2 | |||||||||||||||||||||
| J Sels | 6 | 2 | 4 | 2 | R Carballés Baena | 6 | 6 | ||||||||||||||||||||
| R Olivo | 4 | 6 | 6 | R Olivo | 4 | 4 | |||||||||||||||||||||
| Q | H Casanova | 0r | 2 | R Carballés Baena | 6 | 6 | |||||||||||||||||||||
| 2 | R Carballés Baena | 5 | |||||||||||||||||||||||||
Yannick Hanfmann was the defending champion but chose not to defend his title.
Jonáš Forejtek won the boys' singles tennis title at the 2019 US Open, defeating Emilio Nava 6–7(4–7), 6–0, 6–2 in the final.
Pablo Andújar was the defending champion but chose not to defend his title.
Guido Andreozzi was the defending champion but chose not to defend his title.
Thiago Monteiro was the defending champion and successfully defended his title, defeating Marco Cecchinato 7–6(7–3), 6–7(6–8), 7–5 in the final.
Fabio Fognini was the champion in 2014, when the event was last held, but chose to compete in Dubai instead.
This was the first edition of the tournament, primarily organised due to the cancellation of many tournaments in 2020, due to the Covid-19 pandemic.
Ilya Ivashka was the defending champion but chose not to defend his title.
This was the first edition of the tournament.
Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
Cristian Garín defeated Facundo Bagnis in the final, 6–4, 6–7(3–7), 7–5 to capture the men's singles tennis title at the 2021 Chile Open.
Alexander Zverev defeated top seed Stefanos Tsitsipas in the final, 6–4, 7–6(7–3) to win the men's singles tennis title at the 2021 Mexican Open.
Emilio Gómez was the defending champion but chose not to defend his title.
Aslan Karatsev was the defending champion but chose not to defend his title.
This was the first edition of the tournament since 2011.
Andrey Rublev was the defending champion, but chose to not defend his title as he and other Russian Olympic athletes were sent to Yuzhno-Sakhalinsk for training sessions.
Sumit Nagal was the defending champion but chose not to defend his title.
Hugo Dellien was the defending champion but lost in the quarterfinals to Juan Manuel Cerúndolo.
Francisco Cerúndolo was the defending champion but lost in the second round to Gonçalo Oliveira.
Casper Ruud defeated the defending champion Diego Schwartzman in the final, 5–7, 6–2, 6–3 to win the singles title at the 2022 Argentina Open.