| Singles | |
|---|---|
| 2020 Sparkassen ATP Challenger | |
| Champion |  Ilya Ivashka |
| Runner-up |  Antoine Hoang |
| Score | 6–4, 3–6, 7–6(7–3) |
Jannik Sinner was the defending champion [1] but chose not to defend his title.
Ilya Ivashka won the title after defeating Antoine Hoang 6–4, 3–6, 7–6(7–3) in the final.
Yasutaka Uchiyama (first round) Ilya Ivashka (champion)
Aslan Karatsev (semifinals)
Lorenzo Musetti (first round) Antoine Hoang (final) Federico Gaio (quarterfinals)
Jurij Rodionov (first round)
Martin Kližan (second round)| Semifinals | Final | ||||||||||||
| Alexandre Müller | 6 | 2 | 2 | ||||||||||
| 5 | Antoine Hoang | 3 | 6 | 6 | |||||||||
| 5 | Antoine Hoang | 4 | 6 | 63 | |||||||||
| 2 | Ilya Ivashka | 6 | 3 | 77 | |||||||||
| 3 | Aslan Karatsev | 4 | 4 | ||||||||||
| 2 | Ilya Ivashka | 6 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | Y Uchiyama | 3 | 4 | ||||||||||||||||||||||||
| A Müller | 6 | 6 | A Müller | 77 | 64 | 6 | |||||||||||||||||||||
 J Clarke | 6 | 69 | 6 | J Clarke | 62 | 77 | 3 | ||||||||||||||||||||
| WC | Patric Prinoth | 3 | 711 | 3 | A Müller | 65 | 78 | 7 | |||||||||||||||||||
| S Ofner | 64 | 1 |  I Marchenko | 77 | 66 | 5 | |||||||||||||||||||||
| I Marchenko | 77 | 6 | I Marchenko | w/o | |||||||||||||||||||||||
| H Grenier | 5 | 6 | 6 | H Grenier | |||||||||||||||||||||||
| 7 | J Rodionov | 7 | 4 | 3 | A Müller | 6 | 2 | 2 | |||||||||||||||||||
| 4 | L Musetti | 3 | 65 | 5 | A Hoang | 3 | 6 | 6 | |||||||||||||||||||
| R Marcora | 6 | 77 | R Marcora | 3 | 64 | ||||||||||||||||||||||
| SE | L Klein | 3 | 5 |  J Lenz | 6 | 77 | |||||||||||||||||||||
| J Lenz | 6 | 7 | J Lenz | 78 | 4 | 3 | |||||||||||||||||||||
| Q | P Kotov | 77 | 4 | 6 | 5 | A Hoang | 66 | 6 | 6 | ||||||||||||||||||
 M Cressy | 65 | 6 | 4 | Q | P Kotov | 2 | 4 | ||||||||||||||||||||
| A Rinderknech | 4 | 6 | 65 | 5 | A Hoang | 6 | 6 | ||||||||||||||||||||
| 5 | A Hoang | 6 | 3 | 77 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | F Gaio | 6 | 6 | ||||||||||||||||||||||||
| Q | A Pellegrino | 3 | 4 | 6 | F Gaio | 6 | 7 | ||||||||||||||||||||
| Q |  A Çelikbilek | 6 | 6 | Q | A Çelikbilek | 4 | 5 | ||||||||||||||||||||
 Z Kolář | 4 | 2 | 6 | F Gaio | 63 | 3 | |||||||||||||||||||||
| LL | A Vatutin | 1 | 3 | 3 | A Karatsev | 77 | 6 | ||||||||||||||||||||
| LL | E Karlovskiy | 6 | 6 | LL | E Karlovskiy | 5 | 4 | ||||||||||||||||||||
| M Marterer | 64 | 2 | 3 | A Karatsev | 7 | 6 | |||||||||||||||||||||
| 3 | A Karatsev | 77 | 6 | 3 | A Karatsev | 4 | 4 | ||||||||||||||||||||
| 8 | M Kližan | 6 | 6 | 2 | I Ivashka | 6 | 6 | ||||||||||||||||||||
| WC | G Zeppieri | 1 | 3 | 8 | M Kližan | 4 | 2 | ||||||||||||||||||||
| WC | L Nardi | 64 | 68 | T Macháč | 6 | 6 | |||||||||||||||||||||
| T Macháč | 77 | 710 | T Macháč | 64 | 65 | ||||||||||||||||||||||
| D Masur | 3 | 712 | 3 | 2 | I Ivashka | 77 | 77 | ||||||||||||||||||||
| Q | J Härteis | 6 | 610 | 6 | Q | J Härteis | 66 | 3 | |||||||||||||||||||
| M Viola | 1 | 1 | 2 | I Ivashka | 78 | 6 | |||||||||||||||||||||
| 2 | I Ivashka | 6 | 6 | ||||||||||||||||||||||||
Radu Albot was the defending champion but chose not to defend his title.
Borna Ćorić was the defending champion, but withdrew before the tournament began.
Damir Džumhur was the defending champion, but lost in the quarterfinals to Stan Wawrinka.
Jo-Wilfried Tsonga was the defending champion, but lost in the second round to Gaël Monfils.
Roberto Bautista Agut was the defending champion, but lost in the second round to Nikoloz Basilashvili.
Dominic Thiem was the defending champion, but he chose not to defend his title this year.
Enzo Couacaud was the defending champion but chose not to defend his title.
Dominic Thiem was the defending champion, but chose to compete in the Laver Cup instead.
Antoine Hoang was the defending champion but chose not to defend his title.
Stefanos Tsitsipas was the defending champion and successfully defended his title, defeating Félix Auger-Aliassime in the final, 6–3, 6–4.
Kamil Majchrzak was the defending champion but chose not to defend his title.
The tournament was played on a hard surface. Due to the ongoing COVID-19 pandemic and many ATP tournaments having been cancelled, this year's event was upgraded to ATP 500 level.
Divij Sharan and Igor Zelenay were the defending champions, but both players chose not to participate. Sharan is instead participating at the Cologne tournament and Zelenay at the Sardinia tournament.
Jiří Veselý was the defending champion but chose not to defend his title.
Ilya Ivashka was the defending champion but chose not to defend his title.
Gaël Monfils was the defending champion, but chose not to defend his title.
Rafael Nadal defeated Stefanos Tsitsipas in the final, 6–4, 6–7(6–8), 7–5 to win the singles title at the 2021 Barcelona Open. Nadal saved a championship point en route to his record-extending 12th Barcelona Open title and 61st ATP Tour singles title on clay. It became the second tournament at which Nadal had earned 12 or more victories, after the French Open. At three hours and 38 minutes, the final match was also the longest best-of-three-set tour-level final ever recorded since the Association of Tennis Professionals began tracking statistics in 1991. Tsitsipas, who had also lost to Nadal in his first career ATP singles final at this tournament in 2018, was in contention to win his first ATP 500 tournament title on his seventh attempt.
Alexander Zverev was the defending champion from when the event was held in 2019, but chose not to defend his title.
Benoît Paire was the defending champion from when the event was last held in 2019, but chose to participate in Geneva instead.
Hubert Hurkacz and John Isner defeated Wesley Koolhof and Neal Skupski in the final, 7–6(7–5), 6–4 to win the men's doubles title at the 2022 Miami Open. Isner completed the Sunshine Double, having won the title at Indian Wells alongside Jack Sock. He became the first player to achieve the Sunshine Double in men's doubles since Pierre-Hugues Herbert and Nicolas Mahut in 2016.