| Singles | |
|---|---|
| 2021 Amex-Istanbul Challenger | |
| Champion |  Arthur Rinderknech |
| Runner-up | Benjamin Bonzi |
| Final score | 4–6, 7–6(7–1), 7–6(7–3) |
Ilya Ivashka was the defending champion [1] but chose not to defend his title.
Arthur Rinderknech won the title after defeating Benjamin Bonzi 4–6, 7–6(7–1), 7–6(7–3) in the final.
Daniel Elahi Galán (first round)
Thiago Seyboth Wild (first round) Antoine Hoang (quarterfinals)
Facundo Bagnis (second round)
Prajnesh Gunneswaran (first round, retired)
Lorenzo Musetti (second round)
Jozef Kovalík (semifinals)
Go Soeda (quarterfinals, withdrew)| Semifinals | Final | ||||||||||||
| 7 | Jozef Kovalík | 5 | 4 | ||||||||||
| Q | Arthur Rinderknech | 7 | 6 | ||||||||||
| Q | Arthur Rinderknech | 4 | 77 | 77 | |||||||||
| Benjamin Bonzi | 6 | 61 | 63 | ||||||||||
| Benjamin Bonzi | 77 | 6 | |||||||||||
 Mohamed Safwat | 61 | 4 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | DE Galán | 65 | 3 | ||||||||||||||||||||||||
| Q | J Menezes | 77 | 6 | Q | J Menezes | 2 | 65 | ||||||||||||||||||||
| WC |  E Kırkın | 6 | 6 | WC | E Kırkın | 6 | 77 | ||||||||||||||||||||
| P Lorenzi | 4 | 2 | WC | E Kırkın | 77 | 0 | 63 | ||||||||||||||||||||
 B Zapata Miralles | 4 | 2 | 7 | J Kovalík | 65 | 6 | 77 | ||||||||||||||||||||
| C Taberner | 6 | 6 | C Taberner | 64 | 0 | ||||||||||||||||||||||
| WC | A Çelikbilek | 5 | 6 | 4 | 7 | J Kovalík | 77 | 6 | |||||||||||||||||||
| 7 | J Kovalík | 7 | 2 | 6 | 7 | J Kovalík | 5 | 4 | |||||||||||||||||||
| 4 | F Bagnis | 6 | 6 | Q | A Rinderknech | 7 | 6 | ||||||||||||||||||||
 Zh Zhang | 4 | 1 | 4 | F Bagnis | 5 | 2 | |||||||||||||||||||||
 M-A Hüsler | 2 | 6 | 6 | M-A Hüsler | 7 | 6 | |||||||||||||||||||||
| LL |  D Istomin | 6 | 2 | 4 | M-A Hüsler | 5 | 3 | ||||||||||||||||||||
 B Nakashima | 3 | 6 | 6 | Q | A Rinderknech | 7 | 6 | ||||||||||||||||||||
| WC | C İlkel | 6 | 4 | 3 | B Nakashima | 79 | 1 | 4 | |||||||||||||||||||
| Q | A Rinderknech | 6 | 3 | Q | A Rinderknech | 67 | 6 | 6 | |||||||||||||||||||
| 5 | P Gunneswaran | 4 | 2r | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | L Musetti | 6 | 78 | ||||||||||||||||||||||||
 D Petrović | 4 | 66 | 6 | L Musetti | 1 | 4 | |||||||||||||||||||||
 B Rola | 4 | 1r | B Bonzi | 6 | 6 | ||||||||||||||||||||||
| B Bonzi | 6 | 2 | B Bonzi | 65 | 6 | 7 | |||||||||||||||||||||
| L Giustino | 7 | 77 | 3 | A Hoang | 77 | 1 | 5 | ||||||||||||||||||||
| A Giannessi | 5 | 65 | L Giustino | 4 | 4 | ||||||||||||||||||||||
 E Gómez | 77 | 2 | 4 | 3 | A Hoang | 6 | 6 | ||||||||||||||||||||
| 3 | A Hoang | 63 | 6 | 6 | B Bonzi | 77 | 6 | ||||||||||||||||||||
| 8 | G Soeda | 6 | 6 | M Safwat | 61 | 4 | |||||||||||||||||||||
 A Tabilo | 3 | 3 | 8 | G Soeda | 7 | 4 | 77 | ||||||||||||||||||||
| Q |  L Rosol | 4 | 63 |  T Griekspoor | 5 | 6 | 62 | ||||||||||||||||||||
| T Griekspoor | 6 | 77 | 8 | G Soeda | |||||||||||||||||||||||
| Q |  J Clarke | 3 | 5 | M Safwat | w/o | ||||||||||||||||||||||
| F Gaio | 6 | 7 | F Gaio | 64 | 5 | ||||||||||||||||||||||
| M Safwat | 6 | 6 | M Safwat | 77 | 7 | ||||||||||||||||||||||
| 2 | T Seyboth Wild | 4 | 1 | ||||||||||||||||||||||||
Jo-Wilfried Tsonga was the defending champion, but withdrew before the tournament began.
Evgeny Donskoy was the defending champion but chose not to defend his title.
Yūichi Sugita was the defending champion but chose not to defend his title.
Marin Čilić was the defending champion, but lost in the second round to Malek Jaziri.
Dudi Sela was the defending champion but chose not to defend his title.
Márton Fucsovics was the defending champion but chose not to defend his title.
Cedrik-Marcel Stebe was the defending champion but chose not to defend his title.
Damir Džumhur was the defending champion, but lost in the quarterfinals to Stan Wawrinka.
Jo-Wilfried Tsonga was the defending champion, but lost in the second round to Gaël Monfils.
Nick Kyrgios defeated Daniil Medvedev in the final, 7–6(8–6), 7–6(7–4) to win the men's singles tennis title at the 2019 Washington Open. Kyrgios saved a match point in the semifinals against Stefanos Tsitsipas.
Dominic Thiem was the defending champion, but chose to compete in the Laver Cup instead.
Stefanos Tsitsipas was the defending champion and successfully defended his title, defeating Félix Auger-Aliassime in the final, 6–3, 6–4.
The tournament was played on a hard surface. Due to the ongoing COVID-19 pandemic and many ATP tournaments having been cancelled, this year's event was upgraded to ATP 500 level.
Ugo Humbert was the defending champion but chose not to defend his title.
Jannik Sinner was the defending champion but chose not to defend his title.
Alexander Zverev was the defending champion from when the event was held in 2019, but chose not to defend his title.
John Millman was the defending champion, but lost in the quarterfinals to James Duckworth.
Ilya Ivashka was the defending champion but chose not to defend his title.
Andrey Rublev defeated Félix Auger-Aliassime in the final, 7–5, 7–6(7–4) to win the singles title at the 2022 Open 13 Provence.
Adrian Mannarino defeated Laslo Đere in the final, 7–6(7–1), 6–4 to win the singles tennis title at the 2022 Winston-Salem Open. Mannarino saved four match points en route to the title, in his first-round match against Christopher O'Connell.