| Doubles | |
|---|---|
| 2022 Challenger Città di Lugano | |
| Champions |  Ruben Bemelmans  Daniel Masur |
| Runners-up |  Jérôme Kym Leandro Riedi |
| Score | 6–4, 6–7(5–7), [10–7] |
Andre Begemann and Andrea Vavassori were the defending champions [1] but chose not to defend their title.
Ruben Bemelmans and Daniel Masur won the title after defeating Jérôme Kym and Leandro Riedi 6–4, 6–7(5–7), [10–7] in the final.
Hunter Reese / 
Sem Verbeek (semifinals)
Karol Drzewiecki / Szymon Walków (quarterfinals) Luca Margaroli / 
Lucas Miedler (quarterfinals)
Dan Added / Albano Olivetti (semifinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | H Reese S Verbeek | 77 | 3 | [10] | |||||||||||||||||||||||
 A Šetkić  K Sultanov | 65 | 6 | [7] | 1 | H Reese S Verbeek | 611 | 6 | [10] | |||||||||||||||||||
| M Bašić D Džumhur | 6 | 6 | M Bašić D Džumhur | 713 | 3 | [8] | |||||||||||||||||||||
| G Brouwer P Matuszewski | 1 | 4 | 1 | H Reese S Verbeek | 4 | 4 | |||||||||||||||||||||
| 3 | L Margaroli L Miedler | 77 | 78 | WC | J Kym L Riedi | 6 | 6 | ||||||||||||||||||||
 Y-s Chung  Georgii Kravchenko | 63 | 66 | 3 | L Margaroli L Miedler | 4 | 66 | |||||||||||||||||||||
| WC | K Feldbausch Nicolas Parizzia | WC | J Kym L Riedi | 6 | 78 | ||||||||||||||||||||||
| WC | J Kym L Riedi | w/o | WC | J Kym L Riedi | 4 | 77 | [7] | ||||||||||||||||||||
 R Gonzales  P Raja | 62 | 6 | [6] | R Bemelmans D Masur | 6 | 65 | [10] | ||||||||||||||||||||
 P Kotov  David Poljak | 77 | 2 | [10] | P Kotov D Poljak | 4 | 2 | |||||||||||||||||||||
| J Paul Yannik Steinegger | 3 | 6 | [6] | 4 | D Added A Olivetti | 6 | 6 | ||||||||||||||||||||
| 4 | D Added A Olivetti | 6 | 4 | [10] | 4 | D Added A Olivetti | 66 | 6 | [3] | ||||||||||||||||||
| M Geerts T van Rijthoven | 4 | 77 | [6] | R Bemelmans D Masur | 78 | 4 | [10] | ||||||||||||||||||||
| R Bemelmans D Masur | 6 | 63 | [10] | R Bemelmans D Masur | 7 | 6 | |||||||||||||||||||||
| Alt |  M Bellucci R Bertola | 4 | 6 | [5] | 2 | K Drzewiecki S Walków | 5 | 2 | |||||||||||||||||||
| 2 | K Drzewiecki S Walków | 6 | 4 | [10] | |||||||||||||||||||||||
Agustín Calleri and Mariano Hood were the defending champions but only Hood competed that year with Lucas Arnold.
Gustavo Kuerten and Fernando Meligeni were the defending champions, but Kuerten did not participate this year. Meligeni partnered Luis Lobo, losing in the quarterfinals.
Lucas Arnold and Mariano Hood were the defending champions, but lost in the semifinals this year.
Mahesh Bhupathi and Max Mirnyi were the defending champions, but lost in the quarterfinals to Michaël Llodra and Fabrice Santoro.
Jay Andrijic and Bradley Mousley were the defending champions, but Andrijic was no longer eligible to participate.
Mousley successfully defended the title with Lucas Miedler, defeating Quentin Halys and Johan-Sébastien Tatlot in the final, 6–4, 6–3.
Albert Montañés was the defending champion, but lost to Ernests Gulbis in the semifinals. Gulbis went on to win the title, defeating Federico Delbonis in the final, 6–1, 7–6(7–5).
Federico Delbonis was the defending champion, but lost to Facundo Bagnis in the first round.
Pablo Cuevas won the title, defeating Luca Vanni in the final, 6–4, 3–6, 7–6(7–4).
Yevgeny Kafelnikov and Sargis Sargsian were the defending champions, but did not compete this year, with Kafelnikov retired at the end of the 2003 season.
Andy Murray was the defending champion, but chose not to participate.
David Ferrer won the title, defeating Steve Johnson in the final, 4–6, 6–4, 7–5.
Richard Gasquet was the defending champion, but chose not to participate this year.
Jo-Wilfried Tsonga was the defending champion, but withdrew with a left knee injury before the tournament began.
Nick Kyrgios was the defending champion, but lost in the semifinals to Jo-Wilfried Tsonga.
Dudi Sela was the defending champion but chose not to defend his title.
Lucas Arnold Ker and Martín García were the defending champions, but competed this year with different partners. Arnold Ker teamed up with Pablo Albano and lost in quarterfinals to Devin Bowen and Mariano Hood, while García teamed up with Tomás Carbonell and lost in semifinals to Alberto Martín and Eyal Ran.
Alexander Zverev was the defending champion, but chose not to participate this year.
Lucas Pouille was the defending champion, but lost in the semifinals to Milos Raonic.
Fabio Fognini was the defending champion, but lost in the quarterfinals to Taylor Fritz.
Austin Krajicek and Franko Škugor were the defending champions, but Krajicek chose to compete at the Summer Olympics and Škugor chose not to defend his title.
Chris Haggard and Peter Nyborg were the defending champions, but competed this year with different partners. Haggard teamed up with Tom Vanhoudt and lost in the semifinals to Pablo Albano and Cyril Suk, while Nyborg teamed up with Aleksandar Kitinov and also lost in the semifinals to Joshua Eagle and Andrew Florent.
František Čermák and Leoš Friedl were the defending champions, but none competed this year.