| Singles | |
|---|---|
| 2022 Fairfield Challenger | |
| Champion |  Michael Mmoh |
| Runner-up |  Gabriel Diallo |
| Score | 6–3, 6–2 |
Christopher O'Connell was the defending champion [1] but chose not to defend his title.
Michael Mmoh won the title after defeating Gabriel Diallo 6–3, 6–2 in the final.
Denis Kudla (withdrew) Stefan Kozlov (first round) Michael Mmoh (champion) Ben Shelton (second round)
Enzo Couacaud (quarterfinals) Ernesto Escobedo (first round)
Shang Juncheng (quarterfinals) Mitchell Krueger (first round)| Semifinals | Final | ||||||||||||
| Q | Alafia Ayeni | 3 | 1 | ||||||||||
| Gabriel Diallo | 6 | 6 | |||||||||||
| Gabriel Diallo | 3 | 2 | |||||||||||
| 3 | Michael Mmoh | 6 | 6 | ||||||||||
| 3 | Michael Mmoh | 6 | 6 | ||||||||||
| Q | Sam Riffice | 4 | 4 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| Q | Alafia Ayeni | 6 | 7 | ||||||||||||||||||||||||
 M Pervolarakis | 3 | 5 | Q | A Ayeni | 6 | 6 | |||||||||||||||||||||
| SE | Z Svajda | 6 | 1 | 0 | Q |  A Holmgren | 3 | 4 | |||||||||||||||||||
| Q | A Holmgren | 3 | 6 | 6 | Q | A Ayeni | 6 | 79 | |||||||||||||||||||
 Sebastian Fanselow | 4 | 67 | Q | T Sandgren | 4 | 67 | |||||||||||||||||||||
| Q | T Sandgren | 6 | 79 | Q | T Sandgren | 65 | 6 | 6 | |||||||||||||||||||
| Alt |  G Oradini | 2 | 6 | 6 | Alt | G Oradini | 77 | 4 | 0 | ||||||||||||||||||
| 6 | E Escobedo | 6 | 4 | 4 | Q | A Ayeni | 3 | 1 | |||||||||||||||||||
| 4 | B Shelton | 6 | 6 | G Diallo | 6 | 6 | |||||||||||||||||||||
| WC | Aidan Mayo | 3 | 3 | 4 | B Shelton | 7 | 65 | 3 | |||||||||||||||||||
| G Diallo | 2 | 6 | 6 | G Diallo | 5 | 77 | 6 | ||||||||||||||||||||
 L Riedi | 6 | 4 | 2 | G Diallo | 78 | 7 | |||||||||||||||||||||
| LL |  M Jaziri | 2 | 2 | 5 | E Couacaud | 66 | 5 | ||||||||||||||||||||
| Q | A Perez | 6 | 6 | Q | A Perez | 4 | 5 | ||||||||||||||||||||
 R Quiroz | 61 | 6 | 1 | 5 | E Couacaud | 6 | 7 | ||||||||||||||||||||
| 5 | E Couacaud | 77 | 4 | 6 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | J Shang | 7 | 4 | 6 | |||||||||||||||||||||||
 Charles Broom | 5 | 6 | 3 | 7 | J Shang | 6 | 6 | ||||||||||||||||||||
 V Vacherot | 77 | 77 | V Vacherot | 4 | 3 | ||||||||||||||||||||||
| WC | J Fearnley | 62 | 65 | 7 | J Shang | 3 | 1 | ||||||||||||||||||||
 N Mejía | 6 | 2 | 3 | 3 | M Mmoh | 6 | 6 | ||||||||||||||||||||
| Q |  A Cozbinov | 3 | 6 | 6 | Q | A Cozbinov | 2 | 2 | |||||||||||||||||||
| P Jubb | 2 | 0r | 3 | M Mmoh | 6 | 6 | |||||||||||||||||||||
| 3 | M Mmoh | 6 | 0 | 3 | M Mmoh | 6 | 6 | ||||||||||||||||||||
| 8 | M Krueger | 65 | 77 | 61 | Q | S Riffice | 4 | 4 | |||||||||||||||||||
| A Galarneau | 77 | 64 | 77 | A Galarneau | 6 | 6 | |||||||||||||||||||||
| E Zhu | 6 | 6 | E Zhu | 1 | 4 | ||||||||||||||||||||||
 B Lock | 3 | 4 | A Galarneau | 4 | 63 | ||||||||||||||||||||||
| G Nanda | 4 | 4 | Q | S Riffice | 6 | 77 | |||||||||||||||||||||
| WC | Christian Langmo | 6 | 6 | WC | C Langmo | 77 | 3 | 4 | |||||||||||||||||||
| Q | S Riffice | 3 | 6 | 6 | Q | S Riffice | 65 | 6 | 6 | ||||||||||||||||||
| 2 | S Kozlov | 6 | 2 | 3 | |||||||||||||||||||||||
Three-time defending champion Kei Nishikori successfully defended his title, defeating Taylor Fritz in the final, 6–4, 6–4 to win the singles title at the 2016 Memphis Open. Notably, this was only Fritz' third career event on the ATP Tour.
Roberto Bautista Agut was the defending champion, but withdrew due to a stomach virus.
Ernesto Escobedo was the defending champion but chose not to defend his title.
James McGee was the defending champion but chose not to defend his title.
Santiago Giraldo was the defending champion but chose not to defend his title.
Michael Mmoh was the defending champion but lost in the first round to Bradley Klahn.
Steve Johnson was the defending champion and successfully defended his title, defeating Tennys Sandgren in the final, 7–6(7–2), 2–6, 6–4.
Dudi Sela was the defending champion but chose not to defend his title.
Márton Fucsovics was the defending champion but chose not to defend his title.
Ante Pavić was the defending champion but chose not to defend his title.
Juan Martín del Potro was the two-time defending champion but chose not to defend his title.
Reilly Opelka was the defending champion but chose not to defend his title.
Bradley Klahn was the defending champion but lost in the third round to Michael Mmoh.
Maxime Cressy was the defending champion but lost in the third round to Ulises Blanch.
Ričardas Berankis was the defending champion but chose not to defend his title.
Mitchell Krueger was the defending champion and successfully defended his title.
Reilly Opelka defeated John Isner in the final, 6–3, 7–6(9–7), to win the singles tennis title at the 2022 U.S. Men's Clay Court Championships. It marked Opelka's fourth career Association of Tennis Professionals (ATP) singles title and his first on clay. With Opelka's height at 6 ft 11 in (211 cm) and Isner's at 6 ft 10 in (208 cm), the combined heights of both players made the final the tallest one ever contended during the Open Era. At the age of 36, Isner was also playing to become the oldest champion at the tournament in the Open Era.
Cameron Norrie defeated Alex Molčan in the final, 6–3, 6–7(3–7), 6–1 to win the singles tennis title at the 2022 ATP Lyon Open. Norrie became the first Briton to win a clay court title on the ATP Tour since 2016.
Norbert Gombos was the defending champion but chose not to defend his title.
Mitchell Krueger was the defending champion but lost in the first round to Keegan Smith.