| Singles | |
|---|---|
| 2022 Internationaux de Tennis de Blois | |
| Champion |  Alexandre Müller |
| Runner-up |  Nikola Milojević |
| Score | 7–6(7–3), 6–1 |
Pedro Sousa was the defending champion [1] but chose not to defend his title.
Alexandre Müller won the title after defeating Nikola Milojević 7–6(7–3), 6–1 in the final.
Zdeněk Kolář (first round) Corentin Moutet (first round)
Camilo Ugo Carabelli (second round) Pedro Cachin (first round) Vít Kopřiva (semifinals)
Dennis Novak (second round) Nikola Milojević (final)
Nino Serdarušić (second round)| Semifinals | Final | ||||||||||||
| 7 | Nikola Milojević | 77 | 6 | ||||||||||
| 5 | Vít Kopřiva | 61 | 2 | ||||||||||
| 7 | Nikola Milojević | 63 | 1 | ||||||||||
| Alexandre Müller | 77 | 6 | |||||||||||
| Alexandre Müller | 77 | 6 | |||||||||||
| Q | Luca Van Assche | 64 | 3 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | Z Kolař | 2 | 4 | ||||||||||||||||||||||||
| Q |  E Karlovskiy | 6 | 6 | Q | E Karlovskiy | 2 | 77 | 6 | |||||||||||||||||||
 M Arnaldi | 6 | 6 | M Arnaldi | 6 | 64 | 4 | |||||||||||||||||||||
| E Couacaud | 4 | 2 | Q | E Karlovskiy | 1 | 6 | 2 | ||||||||||||||||||||
 T Skatov | 6 | 77 | 7 | N Milojević | 6 | 4 | 6 | ||||||||||||||||||||
| F Díaz Acosta | 4 | 62 | T Skatov | 6 | 4 | 4 | |||||||||||||||||||||
| G Barrère | 1 | 0 | 7 | N Milojević | 4 | 6 | 6 | ||||||||||||||||||||
| 7 | N Milojević | 6 | 6 | 7 | N Milojević | 77 | 6 | ||||||||||||||||||||
| 4 | P Cachin | 4 | 2 | 5 | V Kopřiva | 61 | 2 | ||||||||||||||||||||
 M Marterer | 6 | 6 | M Marterer | 6 | 77 | ||||||||||||||||||||||
| Q |  A Rybakov | 6 | 7 | Q | A Rybakov | 3 | 64 | ||||||||||||||||||||
 Z Piros | 3 | 5 | M Marterer | 5 | 3 | ||||||||||||||||||||||
| WC | A Fils | 2 | 6 | 2 | 5 | V Kopřiva | 7 | 6 | |||||||||||||||||||
| Em Nava | 6 | 3 | 6 | Em Nava | 1 | 4 | |||||||||||||||||||||
| L Giustino | 6 | 4 | 65 | 5 | V Kopřiva | 6 | 6 | ||||||||||||||||||||
| 5 | V Kopřiva | 2 | 6 | 77 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | D Novak | 6 | 77 | ||||||||||||||||||||||||
| WC | Térence Atmane | 4 | 64 | 6 | D Novak | 2 | 4 | ||||||||||||||||||||
| Q |  S Mochizuki | 6 | 4 | 2 | Alt | GA Olivieri | 6 | 6 | |||||||||||||||||||
| Alt | GA Olivieri | 3 | 6 | 6 | Alt | GA Olivieri | 1 | 1 | |||||||||||||||||||
| A Collarini | 77 | 67 | 4 | A Müller | 6 | 6 | |||||||||||||||||||||
| A Müller | 64 | 79 | 6 | A Müller | 65 | 6 | 6 | ||||||||||||||||||||
| Q |  G Décamps | 2 | 3 | 3 | C Ugo Carabelli | 77 | 4 | 1 | |||||||||||||||||||
| 3 | C Ugo Carabelli | 6 | 6 | A Müller | 77 | 6 | |||||||||||||||||||||
| 8 | N Serdarušić | 6 | 77 | Q | L Van Assche | 64 | 3 | ||||||||||||||||||||
| Alt |  G Lama | 3 | 64 | 8 | N Serdarušić | 3 | 2 | ||||||||||||||||||||
| C-M Stebe | 2 | 3 | Q |  N Sánchez Izquierdo | 6 | 6 | |||||||||||||||||||||
| Q | N Sánchez Izquierdo | 6 | 6 | Q | N Sánchez Izquierdo | 4 | 64 | ||||||||||||||||||||
| A Shevchenko | 65 | 2 | Q | L Van Assche | 6 | 77 | |||||||||||||||||||||
| Q | L Van Assche | 77 | 6 | Q | L Van Assche | 2 | 6 | 6 | |||||||||||||||||||
| E Furness | 6 | 0 | 6 | E Furness | 6 | 4 | 3 | ||||||||||||||||||||
| 2/WC | C Moutet | 4 | 6 | 1 | |||||||||||||||||||||||
Andrés Artuñedo and Roberto Carballés were the defending champions.
Andrew Harris and Nick Kyrgios won the title by defeating Adam Pavlásek and Václav Šafránek in the final, 6–4, 2–6, [10–7]
Filip Peliwo was the defending champion, but was no longer eligible to compete in junior tennis, and thus could not defend his title.
Tristan Lamasine was the defending champion but chose not to defend his title.
Ilya Ivashka was the defending champion but chose not to defend his title.
Lu Yen-hsun was the defending champion but chose not to defend his title.
Pablo Andújar was the defending champion and successfully defended his title.
Marco Trungelliti was the defending champion but chose not to defend his title.
Dragoș Dima was the defending champion but lost in the first round to Václav Šafránek.
Pablo Andújar was the defending champion but chose not to defend his title.
Karen Khachanov was the defending champion, but lost in the quarterfinals to Andreas Seppi.
This was the first edition of the tournament.
Jozef Kovalík was the defending champion but lost in the quarterfinals to Carlos Taberner.
Miomir Kecmanović was the defending champion, but chose to compete at the Summer Olympics instead.
Tallon Griekspoor was the defending champion but chose not to defend his title.
Jaume Munar was the defending champion but chose not to defend his title.
Emil Ruusuvuori was the defending champion but withdrew from the tournament before his first round match.
Albert Ramos Viñolas defeated Alejandro Tabilo in the final, 4–6, 6–3, 6–4 to win the singles title at the 2022 Córdoba Open.
Casper Ruud defeated the defending champion Diego Schwartzman in the final, 5–7, 6–2, 6–3 to win the singles title at the 2022 Argentina Open.
Pedro Martínez defeated Sebastián Báez in the final, 4–6, 6–4, 6–4 to win the singles title at the 2022 Chile Open. It was his first ATP Tour title.
Holger Rune was the defending champion but chose not to defend his title.