| Singles | |
|---|---|
| 2022 Internazionali di Tennis Città di Vicenza | |
| Champion |  Andrea Pellegrino |
| Runner-up |  Andrea Collarini |
| Score | 6–1, 6–4 |
Alessandro Giannessi was the defending champion [1] but chose not to defend his title.
Andrea Pellegrino won the title after defeating Andrea Collarini 6–1, 6–4 in the final.
Gianluca Mager (quarterfinals) Juan Manuel Cerúndolo (quarterfinals) Andreas Seppi (first round) Flavio Cobolli (second round) Renzo Olivo (second round)
Dmitry Popko (first round) Lorenzo Giustino (first round) Salvatore Caruso (first round)| Semifinals | Final | ||||||||||||
| Alt | Andrea Pellegrino | 4 | 6 | 6 | |||||||||
| WC | Matteo Gigante | 6 | 3 | 3 | |||||||||
| Alt | Andrea Pellegrino | 6 | 6 | ||||||||||
| Andrea Collarini | 1 | 4 | |||||||||||
| Alt |  Daniel Dutra da Silva | 2 | 1 | ||||||||||
| Andrea Collarini | 6 | 6 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | G Mager | 6 | 77 | ||||||||||||||||||||||||
| LL |  Yan Bondarevskiy | 3 | 63 | 1 | G Mager | 7 | 6 | ||||||||||||||||||||
| R Bonadio | 2 | 6 | 6 | R Bonadio | 5 | 2 | |||||||||||||||||||||
| Alt |  M Janvier | 6 | 3 | 3 | 1 | G Mager | 4 | 6 | 2 | ||||||||||||||||||
| Q | G Fonio | 6 | 6 | Alt | A Pellegrino | 6 | 4 | 6 | |||||||||||||||||||
| GA Olivieri | 3 | 4 | Q | G Fonio | 68 | 3 | |||||||||||||||||||||
| Alt | A Pellegrino | 6 | 6 | Alt | A Pellegrino | 710 | 6 | ||||||||||||||||||||
| 7 | L Giustino | 4 | 4 | Alt | A Pellegrino | 4 | 6 | 6 | |||||||||||||||||||
| 3 | A Seppi | 1 | 65 | WC | M Gigante | 6 | 3 | 3 | |||||||||||||||||||
| A Arnaboldi | 6 | 77 | A Arnaboldi | 6 | 6 | ||||||||||||||||||||||
| SE | F Maestrelli | 6 | 6 | SE | F Maestrelli | 3 | 2 | ||||||||||||||||||||
| Q | K de Schepper | 4 | 2 | A Arnaboldi | 4 | 5 | |||||||||||||||||||||
| Alt |  A Galarneau | 4 | 6 | 3 | WC | M Gigante | 6 | 7 | |||||||||||||||||||
| WC | M Gigante | 6 | 2 | 6 | WC | M Gigante | 6 | 77 | |||||||||||||||||||
 V Sachko | 3 | 62 | 5 | R Olivo | 3 | 65 | |||||||||||||||||||||
| 5 | R Olivo | 6 | 77 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8/WC | S Caruso | 6 | 5 | 4 | |||||||||||||||||||||||
| Q | O Prihodko | 4 | 7 | 6 | Q | O Prihodko | 2 | 6 | 2 | ||||||||||||||||||
| Q |  N Barrientos | 0 | 4 | Alt | D Dutra da Silva | 6 | 2 | 6 | |||||||||||||||||||
| Alt | D Dutra da Silva | 6 | 6 | Alt | D Dutra da Silva | 5 | 7 | 77 | |||||||||||||||||||
| SE | M Arnaldi | 5 | 6 | 6 | SE | M Arnaldi | 7 | 5 | 64 | ||||||||||||||||||
 N Moreno de Alboran | 7 | 3 | 1 | SE | M Arnaldi | 6 | 4 | 6 | |||||||||||||||||||
| WC | F Passaro | 6 | 4 | 4 | 4 | F Cobolli | 4 | 6 | 4 | ||||||||||||||||||
| 4 | F Cobolli | 2 | 6 | 6 | Alt | D Dutra da Silva | 2 | 1 | |||||||||||||||||||
| 6 | D Popko | 6 | 1 | 2 | A Collarini | 6 | 6 | ||||||||||||||||||||
| Q | F Comesaña | 2 | 6 | 6 | Q | F Comesaña | 2 | 2 | |||||||||||||||||||
 L Rosol | 0 | 3 | A Collarini | 6 | 6 | ||||||||||||||||||||||
| A Collarini | 6 | 6 | A Collarini | 6 | 6 | ||||||||||||||||||||||
| Alt | L Darderi | 6 | 3 | 6 | 2 | JM Cerúndolo | 2 | 3 | |||||||||||||||||||
| Alt |  N Fatić | 3 | 6 | 4 | Alt | L Darderi | 4 | 1 | |||||||||||||||||||
| A Müller | 5 | 4 | 2 | JM Cerúndolo | 6 | 6 | |||||||||||||||||||||
| 2 | JM Cerúndolo | 7 | 6 | ||||||||||||||||||||||||
Juan Ignacio Chela was the defending champion but was eliminated in the semifinals by Pablo Andújar.
Florian Mayer won the title, defeating Pablo Andújar 6–3, 6–1 in the final.
Fabio Fognini was the defending champion but decided not to participate.
Leonardo Mayer won the title, defeating Alessandro Giannessi 6–3, 6–4 in the final.
David Ferrer is the defending champion. He successfully defended his title by defeating 8th seed Fernando Verdasco, 6–1, 6–2 in the final.
Ivo Minář is the defending champion.
Martin Kližan won the title after defeating Filippo Volandri 6–3, 6–2 in the final.
Robin Söderling was the defending champion, but withdrew due to illness.
David Ferrer won the title, defeating Nicolás Almagro 6–2, 6–2 in the final.
Pablo Carreño-Busta was the defending champion but decided not to participate.
Andreas Haider-Maurer won the title by defeating João Sousa 6–3, 6–4 in the final.
Juan Mónaco was the defending champion, but lost to Ivo Karlović in the quarterfinals.
Dominic Thiem was the defending champion, but chose to compete in Rotterdam instead.
Pablo Cuevas was the two-time defending champion and successfully defended his title, defeating Albert Ramos Viñolas in the final, 6–7(3–7), 6–4, 6–4.
Jerzy Janowicz was the defending champion but chose not to defend his title.
Víctor Estrella Burgos was the three-time defending champion and the tournament's only champion to date, but lost in the second round to Gerald Melzer.
Fabio Fognini was the defending champion, but chose not to defend his title.
Hugo Dellien was the defending champion but chose not to defend his title.
Alessandro Giannessi was the defending champion but chose not to defend his title.
Carlos Alcaraz defeated Richard Gasquet in the final, 6–2, 6–2 to win the singles tennis title at the 2021 Croatia Open. It was his first ATP Tour title. With the victory, Alcaraz became the youngest player to win an ATP Tour title since Kei Nishikori at the 2008 Delray Beach International Tennis Championships.
Facundo Mena was the defending champion but chose not to defend his title.
Jaume Munar was the defending champion but chose not to defend his title.
Jozef Kovalík was the defending champion but chose not to defend his title.
Renzo Olivo was the defending champion but lost in the semifinals to Andrea Vavassori.
Juan Manuel Cerúndolo was the defending champion and successfully defended his title, defeating Jesper de Jong 6–3, 2–6, 6–2 in the final.