| Doubles | |
|---|---|
| 2022 São Léo Open | |
| Champions |  Guido Andreozzi Guillermo Durán |
| Runners-up |  Felipe Meligeni Alves João Lucas Reis da Silva |
| Score | 5–1 ret. |
This was the third edition of the tournament as an ATP Challenger Tour event and the first edition since 2012. [1]
Guido Andreozzi and Guillermo Durán won the title leading 5–1 in the final after Felipe Meligeni Alves and João Lucas Reis da Silva retired.
Guido Andreozzi / Guillermo Durán (champions)
Boris Arias / Federico Zeballos (quarterfinals) Daniel Dutra da Silva / 
Luis David Martínez (first round)
Grigoriy Lomakin / 
Damien Wenger (first round)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | G Andreozzi G Durán | 6 | 6 | ||||||||||||||||||||||||
| WC | Fernando Yamacita Nicolas Zanellato | 2 | 4 | 1 | G Andreozzi G Durán | 4 | 6 | [10] | |||||||||||||||||||
| P Boscardin Dias E Ribeiro | 2 | 4 |  N Hardt G Roveri Sidney | 6 | 0 | [4] | |||||||||||||||||||||
| N Hardt Gabriel Roveri Sidney | 6 | 6 | 1 | G Andreozzi G Durán | 6 | 6 | |||||||||||||||||||||
| 4 | G Lomakin D Wenger | 62 | 65 | O Luz M Zormann | 3 | 2 | |||||||||||||||||||||
| O Luz M Zormann | 77 | 77 | O Luz M Zormann | 7 | 77 | ||||||||||||||||||||||
| WC | Lorenzo Esquici J Fonseca | 6 | 6 | WC | L Esquici J Fonseca | 5 | 61 | ||||||||||||||||||||
| JP Paz G Villanueva | 3 | 3 | 1 | G Andreozzi G Durán | 5 | ||||||||||||||||||||||
| F Meligeni Alves JL Reis da Silva | 1r | ||||||||||||||||||||||||||
| Wilson Leite T Seyboth Wild | 6 | 2 | [2] | ||||||||||||||||||||||||
| F Meligeni Alves JL Reis da Silva | 3 | 6 | [10] | F Meligeni Alves JL Reis da Silva | 3 | 6 | [10] | ||||||||||||||||||||
| 3 | D Dutra da Silva LD Martínez | 6 | 4 | [4] | F Meligeni Alves JL Reis da Silva | w/o | |||||||||||||||||||||
| M Alves G Heide | w/o | M Alves G Heide | |||||||||||||||||||||||||
| R Olivo TA Tirante | M Alves G Heide | 6 | 6 | ||||||||||||||||||||||||
 J Domingues G Elias | 3 | 4 | 2 | B Arias F Zeballos | 2 | 3 | |||||||||||||||||||||
| 2 | B Arias F Zeballos | 6 | 6 | ||||||||||||||||||||||||
Guido Andreozzi and Máximo González were the defending champions, but they chose not to compete together. Andreozzi chose to partner with Guillermo Durán, but lost in the quarterfinals to Rafael Matos and Marcelo Zormann. González chose not to compete.
Guillermo Durán and Máximo González were the defending champions, but González chose to participate at Shenzhen instead. Durán partnered with Guido Andreozzi and won the title by defeating Facundo Bagnis and Diego Schwartzman 6–3, 6–3 in the final.
This was the first edition of the event.
Guillermo Durán and Máximo González were the defending champions, but González chose not to play this year. Guillermo Durán played alongside Andrés Molteni and lost in the first round to Guido Andreozzi and Guido Pella.
Daniele Bracciali and Potito Starace were the defending champions, but they decided not to participate this year.
Guido Andreozzi and Guillermo Durán are the defending champions, but only Guido Andreozzi is playing in this year's edition.
Andrej Martin and Hans Podlipnik won the title, beating Rogério Dutra Silva and João Souza 6–3, 6–4
Romain Arneodo and Fernando Romboli were the defending champions but only Romboli chose to defend his title, partnering Fabrício Neis. Romboli lost in the first round to Sergio Galdós and Federico Zeballos.
Facundo Bagnis and Ariel Behar were the defending champions but only Bagnis chose to defend his title, partnering Franco Agamenone. Bagnis lost in the first round to Sander Gillé and Joran Vliegen.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions but chose not to defend their title.
This was the first edition of the tournament.
Luciano Darderi and Juan Bautista Torres were the defending champions but only Torres chose to defend his title, partnering Thiago Agustín Tirante. Torres lost in the semifinals to Román Andrés Burruchaga and Facundo Díaz Acosta.
Julio Peralta and Horacio Zeballos were the defending champions when the event was last held in 2015, but they chose not to defend their title.
Francesco Forti and Giulio Zeppieri were the defending champions but chose not to defend their title.
Rafael Matos and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Matheus Pucinelli de Almeida. Meligeni Alves withdrew before his first round match due to injury.
This was the first edition of the tournament.
Ignacio Carou and Facundo Mena were the defending champions but chose not to defend their title.
Jesper de Jong and Bart Stevens were the defending champions but only de Jong chose to defend his title, partnering Max Houkes. De Jong and Houkes retired from their first round match against Boris Arias and Federico Zeballos.
Alexander Erler and Lucas Miedler defeated Nathaniel Lammons and Jackson Withrow in the final, 7–6(11–9), 7–6(7–3) to win the doubles tennis title at the 2023 Mexican Open.
Orlando Luz and Marcelo Zormann were the defending champions but lost in the first round to Mariano Kestelboim and Juan Bautista Torres.