Ariel Behar and Enrique López Pérez were the defending champions but only López Pérez chose to defend his title, partnering Alejandro Davidovich Fokina. Davidovich Fokina and López Pérez retired in their first round match against Karol Drzewiecki and Szymon Walków.
Guillermo Durán and Roberto Quiroz were the defending champions but only Quiroz chose to defend his title, partnering Yannick Hanfmann. Quiroz lost in the first round to Luis David Martínez and Felipe Meligeni Alves.
Ariel Behar and Gonzalo Escobar were the defending champions but only Escobar chose to defend his title, partnering Diego Hidalgo. Escobar lost in the first round to Íñigo Cervantes and Oriol Roca Batalla.
Franco Agamenone and Fernando Romboli were the defending champions but chose not to defend their title.
André Göransson and Nathaniel Lammons were the defending champions but chose not to defend their title.
Andre Begemann and Florin Mergea were the defending champions but chose not to defend their title.
Sadio Doumbia and Fabien Reboul were the defending champions but chose not to defend their title.
Luis David Martínez and Felipe Meligeni Alves were the defending champions but chose to defend their title with different partners. Martínez partnered Fernando Romboli but lost in the semifinals to Nicolás Barrientos and Alejandro Gómez. Meligeni Alves partnered Rafael Matos but withdrew before the final due to a positive test for COVID-19.
David Vega Hernández and Mark Vervoort were the defending champions but chose not to defend their title.
Guillermo Durán and Nicolás Mejía were the defending champions but chose not to defend their title.
Jesper de Jong and Bart Stevens were the defending champions but only de Jong chose to defend his title, partnering Max Houkes. De Jong and Houkes retired from their first round match against Boris Arias and Federico Zeballos.
The 2022 Uruguay Open was a professional tennis tournament played on red clay courts in Montevideo. It was the 17th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place at the Carrasco Lawn Tennis Club in Montevideo, Uruguay between 7 and 13 November 2022.
This was the third edition of the tournament as an ATP Challenger Tour event and the first edition since 2012.
Guillermo Durán and Felipe Meligeni Alves were the defending champions but chose not to defend their title.
Diego Hidalgo and Cristian Rodríguez were the defending champions but only Rodríguez chose to defend his title, partnering Luis David Martínez. Rodríguez lost in the first round to Hugo and Murkel Dellien.
Corentin Moutet was the defending champion but chose not to defend his title.
Tallon Griekspoor was the defending champion but chose not to defend his title.
Jan Choinski was the defending champion but lost in the second round to Andrea Pellegrino.
Jay Clarke and Marcus Willis were the defending champions but only Willis chose to defend his title, partnering Arjun Kadhe. Willis lost in the final to Karol Drzewiecki and Piotr Matuszewski.
Andrew Harris and Christian Harrison were the defending champions but chose not to defend their title.
Karol Drzewiecki 
Facundo Díaz Acosta 
Luis David Martínez 
