| Singles | |
|---|---|
| 2022 Zagreb Ladies Open | |
| Champion |  Jule Niemeier |
| Runner-up |  Réka Luca Jani |
| Final score | 6–2, 6–2 |
Anhelina Kalinina was the defending champion [1] but chose not to participate.
Jule Niemeier won the title, defeating Réka Luca Jani in the final, 6–2, 6–2.
Donna Vekić (first round) Jule Niemeier (champion) Réka Luca Jani (final)
Paula Ormaechea (second round)
Polona Hercog (first round)
Despina Papamichail (second round) Anna-Lena Friedsam (first round, retired)
Linda Nosková (second round)| Semifinals | Final | ||||||||||||
 Dea Herdželaš | 0 | 0r | |||||||||||
| 3 | Réka Luca Jani | 6 | 3 | ||||||||||
| 3 | Réka Luca Jani | 2 | 2 | ||||||||||
| 2 | Jule Niemeier | 6 | 6 | ||||||||||
| WC | Petra Marčinko | 64 | 1 | ||||||||||
| 2 | Jule Niemeier | 77 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1/WC | D Vekić | 4 | 4 | ||||||||||||||||||||||||
 J Fourlis | 6 | 6 | J Fourlis | 3 | 3 | ||||||||||||||||||||||
| D Herdželaš | 5 | 6 | 6 | D Herdželaš | 6 | 6 | |||||||||||||||||||||
| WC | L Ćirić Bagarić | 7 | 3 | 1 | D Herdželaš | 1 | 7 | 6 | |||||||||||||||||||
 K von Deichmann | 6 | 2 | 6 | Q | T Lukas | 6 | 5 | 4 | |||||||||||||||||||
 V Kužmová | 3 | 6 | 2 | K von Deichmann | 3 | 6 | 3 | ||||||||||||||||||||
| Q | T Lukas | 6 | 4 | Q | T Lukas | 6 | 3 | 6 | |||||||||||||||||||
| 7 | A-L Friedsam | 0 | 1r | D Herdželaš | 0 | 0r | |||||||||||||||||||||
| 3 | RL Jani | 6 | 6 | 3 | RL Jani | 6 | 3 | ||||||||||||||||||||
 J Grabher | 3 | 2 | 3 | RL Jani | 78 | 6 | |||||||||||||||||||||
| Q | N Potočnik | 6 | 7 | Q | N Potočnik | 66 | 4 | ||||||||||||||||||||
 H Chang | 2 | 5 | 3 | RL Jani | 6 | 6 | |||||||||||||||||||||
| B Haas | 4 | 6 | 2 | Q | A Ružić | 4 | 1 | ||||||||||||||||||||
| Q | T Würth | 6 | 2 | 6 | Q | T Würth | 4 | 1 | |||||||||||||||||||
| Q | A Ružić | 7 | 6 | Q | A Ružić | 6 | 6 | ||||||||||||||||||||
| 5 | P Hercog | 5 | 3 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | D Papamichail | 3 | 3 | ||||||||||||||||||||||||
| J Fett | 6 | 1r | 6 | D Papamichail | 1 | 3 | |||||||||||||||||||||
 C Ferrando | 6 | 4 | 5 | WC | P Marčinko | 6 | 6 | ||||||||||||||||||||
| WC | P Marčinko | 4 | 6 | 7 | WC | P Marčinko | 6 | 6 | |||||||||||||||||||
 A Kulikova | 4 | 7 | 4 |  K Zavatska | 3 | 1 | |||||||||||||||||||||
| K Zavatska | 6 | 5 | 6 | K Zavatska | 6 | 6 | |||||||||||||||||||||
| WC |  L Radivojević | 2 | 3 | 4 | P Ormaechea | 1 | 0 | ||||||||||||||||||||
| 4 | P Ormaechea | 6 | 6 | WC | P Marčinko | 64 | 1 | ||||||||||||||||||||
| 8 | L Nosková | 7 | 7 | 2 | J Niemeier | 77 | 6 | ||||||||||||||||||||
| Q | L Bošković | 5 | 5 | 8 | L Nosková | 3 | 7 | 0 | |||||||||||||||||||
| Q |  E Makarova | 6 | 4 | 2 | I Shymanovich | 6 | 5 | 6 | |||||||||||||||||||
| I Shymanovich | 4 | 6 | 6 | I Shymanovich | 4 | 61 | |||||||||||||||||||||
| Q | E Lys | 6 | 4 | 2 | J Niemeier | 6 | 77 | ||||||||||||||||||||
| N Vikhlyantseva | 4 | 1r | Q | E Lys | 0r | ||||||||||||||||||||||
| Q | Ž Falkner | 2 | 4 | 2 | J Niemeier | 3 | |||||||||||||||||||||
| 2 | J Niemeier | 6 | 6 | ||||||||||||||||||||||||
Anastasia Pavlyuchenkova and Urszula Radwańska were the defending champions but did not compete in the Juniors this year.
Kateryna Bondarenko was the defending champion, but chose not to participate.
Caroline Wozniacki was the defending champion, but lost to Angelique Kerber 6–4, 6–4 in the final.
Elizaveta Ianchuk and Julia Mayr were the defending champions, but both decided not to participate.
Simona Halep was the defending champion, but chose not to participate this year.
Florencia Molinero and Stephanie Vogt were the defending champions, but Molinero chose not to participate. Vogt partnered Réka-Luca Jani, but lost in the final to Başak Eraydın and Lidziya Marozava, 6–4, 6–4.
Shahar Pe'er is the defending champion, but chose not to participate this year.
Lesia Tsurenko was the defending champion, but lost in the first round to Sorana Cîrstea.
Teliana Pereira was the defending champion, but lost in the first round to Lyudmyla Kichenok.
Annika Beck and Laura Siegemund were the defending champions, but chose not to participate this year.
Anastasia Potapova was the defending champion, but chose to compete in the Ladies' Singles main draw as a qualifier, where she retired in the first round against Tatjana Maria.
Jana Čepelová was the defending champion, but lost in the first round to Réka Luca Jani.
Barbora Krejčíková was the defending champion, having won the previous edition in 2019, but chose not to participate.
Katarina Zavatska was the defending champion but chose not to participate.
Andrea Sestini Hlaváčková and Lucie Hradecká were the defending champions having won the previous edition in 2013, but Hradecká chose to compete at the 2021 Prague Open instead, whilst Sestini Hlaváčková retired from professional tennis in 2019.
Jeļena Ostapenko was the defending champion, having won the previous edition in 2019, but lost to Clara Tauson in the final, 3–6, 6–4, 4–6.
Barbora Krejčíková was the defending champion but chose not to participate.
Katy Dunne was the defending champion but chose not to participate.
Karolína Muchová was the reigning champion, but chose not to participate.
Jule Niemeier was the defending champion but chose not to participate.