| Singles | |
|---|---|
| 2023 Challenger Ciudad de Guayaquil | |
| Champion |  Alejandro Tabilo |
| Runner-up |  Daniel Elahi Galán |
| Score | 6–2, 6–2 |
Daniel Altmaier was the defending champion [1] but chose not to defend his title.
Alejandro Tabilo won the title after defeating Daniel Elahi Galán 6–2, 6–2 in the final.
Federico Coria (quarterfinals) Daniel Elahi Galán (final) Facundo Díaz Acosta (quarterfinals, retired) Juan Manuel Cerúndolo (first round) Alejandro Tabilo (champion)
Hugo Dellien (quarterfinals)
Felipe Meligeni Alves (semifinals) Camilo Ugo Carabelli (quarterfinals)| Semifinals | Final | ||||||||||||
| 5 | Alejandro Tabilo | 6 | 6 | ||||||||||
| Román Andrés Burruchaga | 3 | 4 | |||||||||||
| 5 | Alejandro Tabilo | 6 | 6 | ||||||||||
| 2/WC | Daniel Elahi Galán | 2 | 2 | ||||||||||
| 7 | Felipe Meligeni Alves | 4 | 65 | ||||||||||
| 2/WC | Daniel Elahi Galán | 6 | 77 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | F Coria | 6 | 5 | 6 | |||||||||||||||||||||||
| Q |  Gerard Campana Lee | 0 | 7 | 1 | 1 | F Coria | 4 | 6 | 6 | ||||||||||||||||||
 F Agamenone | 6 | 4 | 6 | F Agamenone | 6 | 4 | 3 | ||||||||||||||||||||
 Oliver Crawford | 3 | 6 | 1 | 1 | F Coria | 77 | 4 | 4 | |||||||||||||||||||
| WC |  A Andrade | 3 | 4 | 5 | A Tabilo | 64 | 6 | 6 | |||||||||||||||||||
| M Pucinelli de Almeida | 6 | 6 | M Pucinelli de Almeida | 6 | 1 | 2 | |||||||||||||||||||||
| Q | JB Torres | 4 | 1 | 5 | A Tabilo | 4 | 6 | 6 | |||||||||||||||||||
| 5 | A Tabilo | 6 | 6 | 5 | A Tabilo | 6 | 6 | ||||||||||||||||||||
| 4 | JM Cerúndolo | 4 | 2 | RA Burruchaga | 3 | 4 | |||||||||||||||||||||
| RA Burruchaga | 6 | 6 | RA Burruchaga | 5 | 6 | 6 | |||||||||||||||||||||
| WC | Á Guillén Meza | 4 | 6 | 4 |  L Neumayer | 7 | 0 | 4 | |||||||||||||||||||
| L Neumayer | 6 | 2 | 6 | RA Burruchaga | 6 | 5 | 6 | ||||||||||||||||||||
| L Darderi | 6 | 6 | 8 | C Ugo Carabelli | 4 | 7 | 1 | ||||||||||||||||||||
 D Svrčina | 2 | 3 | L Darderi | 6 | 65 | 2 | |||||||||||||||||||||
| JL Reis da Silva | 4 | 0 | 8 | C Ugo Carabelli | 4 | 77 | 6 | ||||||||||||||||||||
| 8 | C Ugo Carabelli | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | F Meligeni Alves | 4 | 6 | 6 | |||||||||||||||||||||||
| Q | N Mejía | 6 | 2 | 4 | 7 | F Meligeni Alves | 5 | 6 | 6 | ||||||||||||||||||
| Q |  M Houkes | 6 | 6 | Q | M Houkes | 7 | 3 | 4 | |||||||||||||||||||
| Q |  C Taberner | 3 | 1 | 7 | F Meligeni Alves | 6 | 3 | ||||||||||||||||||||
| Q |  G Bueno | 0 | 4 | 3 | F Díaz Acosta | 1 | 1r | ||||||||||||||||||||
| M Trungelliti | 6 | 6 | M Trungelliti | 1 | 6 | 65 | |||||||||||||||||||||
| M Dellien | 3 | 2 | 3 | F Díaz Acosta | 6 | 1 | 77 | ||||||||||||||||||||
| 3 | F Díaz Acosta | 6 | 6 | 7 | F Meligeni Alves | 4 | 65 | ||||||||||||||||||||
| 6 | H Dellien | 6 | 7 | 2/WC | DE Galán | 6 | 77 | ||||||||||||||||||||
| LL | Alex Barrena | 2 | 5 | 6 | H Dellien | 6 | 4 | 6 | |||||||||||||||||||
| S Rodríguez Taverna | 6 | 6 | S Rodríguez Taverna | 2 | 6 | 3 | |||||||||||||||||||||
| Tristan Boyer | 1 | 4 | 6 | H Dellien | 1 | 2 | |||||||||||||||||||||
 R Pacheco Méndez | 1 | 6 | 65 | 2/WC | DE Galán | 6 | 6 | ||||||||||||||||||||
 E Ymer | 6 | 2 | 77 | E Ymer | 3 | 2 | |||||||||||||||||||||
 K Feldbausch | 3 | 77 | 0r | 2/WC | DE Galán | 6 | 6 | ||||||||||||||||||||
| 2/WC | DE Galán | 6 | 64 | 5 | |||||||||||||||||||||||
Matteo Berrettini was the defending champion but chose not to defend his title.
Matteo Berrettini was the defending champion, but withdrew with an ankle injury before the tournament began.
Jaume Munar was the defending champion but lost in the final to Carlos Taberner 4–6, 1–6.
Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
Filip Krajinović was the defending champion but chose not to defend his title.
Daniel Elahi Galán was the defending champion but chose not to defend his title.
Jannik Sinner was the defending champion and successfully defended his title, defeating Gaël Monfils in the final, 6–3, 6–4.
Marcelo Arévalo was the defending champion but chose not to defend his title.
Francisco Cerúndolo was the defending champion but lost in the second round to Gonçalo Oliveira.
Sebastian Ofner was the defending champion but chose not to defend his title.
Sebastián Báez was the defending champion but chose not to participate.
Albert Ramos Viñolas defeated Alejandro Tabilo in the final, 4–6, 6–3, 6–4 to win the singles title at the 2022 Córdoba Open.
Tommy Paul was the defending champion but chose not to defend his title.
Bernabé Zapata Miralles was the defending champion but lost in the quarterfinals to Andrej Martin.
Daniel Altmaier was the defending champion but chose not to defend his title.
Alejandro Tabilo was the defending champion but chose not to defend his title.
Daniel Elahi Galán was the defending champion but chose not to defend his title.
Marc-Andrea Hüsler was the defending champion but lost in the second round to Federico Gaio.
Daniel Elahi Galán was the defending champion but lost in the final to Daniel Altmaier.
Daniel Altmaier was the defending champion but chose not to defend his title.