| 2023 Challenger de Santiago | |
|---|---|
| Date | 6–12 March |
| Edition | 17th |
| Surface | Clay |
| Location | Santiago, Chile |
| Champions | |
| Singles | |
 Hugo Dellien | |
| Doubles | |
 Pedro Boscardin Dias / João Lucas Reis da Silva | |
The 2023 Challenger de Santiago was a professional tennis tournament played on clay courts. It was the 17th edition of the tournament which was part of the 2023 ATP Challenger Tour. It took place in Santiago, Chile between 6 and 12 March 2023.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 CHI | |||
 ITA | Marco Cecchinato | 91 | 2 |
 ARG | Facundo Bagnis | 94 | 3 |
| BOL | Hugo Dellien | 96 | 4 |
| ARG | Juan Manuel Cerúndolo | 108 | 5 |
| ARG | Camilo Ugo Carabelli | 122 | 6 |
| ITA | Franco Agamenone | 164 | 7 |
| ARG | Facundo Díaz Acosta | 171 | 8 |
The following players received wildcards into the singles main draw:
Gonzalo Lama Nicolás VillalónThe following players received entry from the qualifying draw:
Daniel Dutra da Silva Federico Gaio 
Hugo Gaston 
Álvaro López San Martín Thiago Seyboth Wild Juan Bautista Torres The following players received entry as lucky losers:
Hugo Dellien def. Thiago Seyboth Wild 3–6, 6–3, 6–3. Pedro Boscardin Dias / João Lucas Reis da Silva def. 
Diego Hidalgo / 
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