| 2022 Challenger de Santiago | |
|---|---|
| Date | 7–13 March |
| Edition | 16th |
| Surface | Clay |
| Location | Santiago, Chile |
| Champions | |
| Singles | |
 Hugo Dellien | |
| Doubles | |
 Diego Hidalgo /  Cristian Rodríguez | |
The 2022 Challenger de Santiago was a professional tennis tournament played on clay courts. It was the 16th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Santiago, Chile between 7 and 13 March 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 CZE | Jiří Lehečka | 94 | 1 |
 CHI | Alejandro Tabilo | 98 | 2 |
| BOL | Hugo Dellien | 103 | 3 |
 PER | Juan Pablo Varillas | 116 | 4 |
 ARG | Tomás Martín Etcheverry | 124 | 5 |
| ARG | Juan Ignacio Londero | 132 | 6 |
| CHI | Nicolás Jarry | 146 | 7 |
| CHI | Tomás Barrios Vera | 149 | 8 |
The following players received wildcards into the singles main draw:
Ignacio Becerra Diego Fernández Flores Daniel Antonio NúñezThe following players received entry from the qualifying draw:
Hernán Casanova 
Evan Furness Facundo Juárez
Paul Jubb Matteo Martineau Juan Bautista Torres The following player received entry as a lucky loser:
Hugo Dellien def. Alejandro Tabilo 6–3, 4–6, 6–4. Diego Hidalgo / Cristian Rodríguez def. Pedro Cachin / Facundo Mena 6–4, 6–4.