| 2022 Sanremo Challenger | |
|---|---|
| Date | 4–10 April |
| Edition | 10th |
| Surface | Clay |
| Location | Sanremo, Italy |
| Champions | |
| Singles | |
 Holger Rune | |
| Doubles | |
 Geoffrey Blancaneaux / Alexandre Müller | |
The 2022 Sanremo Challenger was a professional tennis tournament played on clay courts. It was the tenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Sanremo, Italy between 4 and 10 April 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| DEN | Holger Rune | 88 | 1 |
 ITA | Gianluca Mager | 99 | 2 |
 MDA | Radu Albot | 117 | 3 |
| FRA | Pierre-Hugues Herbert | 134 | 4 |
| FRA | Hugo Grenier | 154 | 5 |
| ITA | Flavio Cobolli | 165 | 6 |
| ITA | Thomas Fabbiano | 173 | 7 |
| FRA | Alexandre Müller | 209 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Edoardo Lavagno Matteo Martineau Francesco Passaro 
Khumoyun Sultanov 
Valentin Vacherot 
Máté Valkusz Holger Rune def. Francesco Passaro 6–1, 2–6, 6–4. Geoffrey Blancaneaux / Alexandre Müller def. Flavio Cobolli / Matteo Gigante 4–6, 6–3, [11–9].