| 2022 Pereira Challenger | |
|---|---|
| Date | 28 March–4 April |
| Edition | 1st |
| Surface | Clay |
| Location | Pereira, Colombia |
| Champions | |
| Singles | |
 Facundo Bagnis | |
| Doubles | |
 Luis David Martínez /  Cristian Rodríguez | |
The 2022 Pereira Challenger was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Pereira, Colombia between 28 March and 4 April 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ARG | Facundo Bagnis | 104 | 1 |
| ARG | Tomás Martín Etcheverry | 108 | 2 |
 PER | Juan Pablo Varillas | 119 | 3 |
 USA | Stefan Kozlov | 120 | 4 |
| ARG | Facundo Mena | 181 | 5 |
 NED | Jesper de Jong | 189 | 6 |
| ARG | Thiago Agustín Tirante | 197 | 7 |
| ARG | Nicolás Kicker | 203 | 8 |
The following players received wildcards into the singles main draw:
Nicolás Barrientos Mateo Gómez Alejandro González The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Elmar Ejupovic Juan Sebastián Gómez Facundo Juárez
Yshai Oliel 
Oleg Prihodko 
Roberto Quiroz The following player received entry as a lucky loser:
Facundo Bagnis def. Facundo Mena 6–3, 6–0. Luis David Martínez / Cristian Rodríguez def. 
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