| 2022 Las Vegas Challenger | |
|---|---|
| Date | 24 – 30 October |
| Edition | 7th |
| Surface | Hard / Outdoors |
| Location | Las Vegas, United States |
| Champions | |
| Singles | |
 Tennys Sandgren | |
| Doubles | |
 Julian Cash / Henry Patten | |
The 2022 Las Vegas Challenger was a professional tennis tournament played on hard courts. It was the seventh edition of the revamped tournament which was the part of the 2022 ATP Challenger Tour. It took place in Las Vegas, United States between 24 and 30 October 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| USA | Denis Kudla | 99 | 1 |
| USA | Steve Johnson | 117 | 2 |
 CAN | Vasek Pospisil | 121 | 3 |
| USA | Stefan Kozlov | 133 | 4 |
 ARG | Juan Pablo Ficovich | 143 | 5 |
| USA | Ben Shelton | 159 | 6 |
| ARG | Facundo Mena | 161 | 7 |
| USA | Aleksandar Kovacevic | 165 | 8 |
The following players received wildcards into the singles main draw:
Alexander Cozbinov Cannon Kingsley 
Maxim VerbovenThe following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Tennys Sandgren def. Stefan Kozlov 7–5, 6–3. Julian Cash / Henry Patten def. 
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