| 2022 Monterrey Challenger | |
|---|---|
| Date | 7–13 March |
| Edition | 12th |
| Surface | Hard |
| Location | Monterrey, Mexico |
| Champions | |
| Singles | |
 Fernando Verdasco | |
| Doubles | |
 Hans Hach Verdugo /  Austin Krajicek | |
The 2022 Monterrey Challenger was a professional tennis tournament played on hard courts. It was the twelfth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Monterrey, Mexico from 7 to 13 March 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
| ESP | Fernando Verdasco | 153 | 1 |
 GBR | Jay Clarke | 173 | 2 |
 TPE | Jason Jung | 218 | 3 |
 GER | Cedrik-Marcel Stebe | 222 | 4 |
 ARG | Juan Pablo Ficovich | 227 | 5 |
 FRA | Maxime Janvier | 239 | 6 |
 IND | Prajnesh Gunneswaran | 246 | 7 |
| FRA | Geoffrey Blancaneaux | 247 | 8 |
The following players received wildcards into the singles main draw:
Milledge Cossu Ryan Harrison Alex Hernández The following players received entry into the singles main draw using protected rankings:
The following players received entry from the qualifying draw:
Fernando Verdasco def. Prajnesh Gunneswaran 4–6, 6–3, 7–6(7–3). Hans Hach Verdugo / Austin Krajicek def. Robert Galloway / 
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