| 2022 Orlando Open | |
|---|---|
| Date | June 6–12 |
| Edition | 5th |
| Surface | Hard |
| Location | Orlando, Florida, United States |
| Champions | |
| Singles | |
 Wu Yibing | |
| Doubles | |
 Chung Yun-seong /  Michail Pervolarakis | |
The 2022 Orlando Open was a professional tennis tournament played on hard courts. It was the fifth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Orlando, Florida, United States between June 6 and 12 2022.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 USA | J. J. Wolf | 125 | 1 |
 ECU | Emilio Gómez | 151 | 2 |
| USA | Christopher Eubanks | 156 | 3 |
 AUS | Jason Kubler | 159 | 4 |
| USA | Michael Mmoh | 175 | 5 |
 TUR | Altuğ Çelikbilek | 179 | 6 |
| USA | Bjorn Fratangelo | 185 | 7 |
| AUS | Rinky Hijikata | 233 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw using protected rankings:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Adrian Andreev Martin Damm 
Gilbert Klier Júnior
Matija Pecotić Michail Pervolarakis Keegan Smith Wu Yibing def. Jason Kubler 6–7(5–7), 6–4, 3–1 ret. Chung Yun-seong / Michail Pervolarakis def. 
Malek Jaziri / 
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